Structure of Adeno-Associated Virus Serotype 8, a Gene Therapy Vector (Q27647639)

11

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Brittney L Gurda

object named as

Brittney Gurda

4

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Barry Byrne

8

object named as

Barry Byrne

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author name string

Hyun-Joo Nam

1

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Michael Douglas Lane

2

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Eric Padron

3

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Erik Kohlbrenner

6

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George Aslanidi

7

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Nicholas Muzyczka

9

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Sergei Zolotukhin

SWISS-MODEL: An automated protein homology-modeling server

10

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publication date

November 2007

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published in

Journal of Virology

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volume

81

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page(s)

12260-71

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issue

22

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cites work

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Adeno-associated virus serotype 4 (AAV4) and AAV5 both require sialic acid binding for hemagglutination and efficient transduction but differ in sialic acid linkage specificity

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Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons

20 March 2017

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Serotype-specific entry of dengue virus into liver cells: identification of the 37-kilodalton/67-kilodalton high-affinity laminin receptor as a dengue virus serotype 1 receptor

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Identification of interaction domains of the prion protein with its 37-kDa/67-kDa laminin receptor

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The 37/67-kilodalton laminin receptor is a receptor for adeno-associated virus serotypes 8, 2, 3, and 9

20 March 2017

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Structurally mapping the diverse phenotype of adeno-associated virus serotype 4.

29 September 2017

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Adeno-associated virus type 2 capsids with externalized VP1/VP2 trafficking domains are generated prior to passage through the cytoplasm and are maintained until uncoating occurs in the nucleus

29 September 2017

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Single amino acid changes can influence titer, heparin binding, and tissue tropism in different adeno-associated virus serotypes

29 September 2017

1 reference

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Alpha2,3 and alpha2,6 N-linked sialic acids facilitate efficient binding and transduction by adeno-associated virus types 1 and 6

29 September 2017

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Production, purification, crystallization and preliminary X-ray analysis of adeno-associated virus serotype 8.

29 September 2017

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VP2 cleavage and the leucine ring at the base of the fivefold cylinder control pH-dependent externalization of both the VP1 N terminus and the genome of minute virus of mice

29 September 2017

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Parvoviral virions deploy a capsid-tethered lipolytic enzyme to breach the endosomal membrane during cell entry

29 September 2017

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Molecular characterization of adeno-associated viruses infecting children

29 September 2017

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Structural determinants of tissue tropism and in vivo pathogenicity for the parvovirus minute virus of mice

29 September 2017

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Structure of adeno-associated virus type 4.

29 September 2017

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Efficacy of an adeno-associated virus 8-pseudotyped vector in glycogen storage disease type II.

29 September 2017

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Two novel adeno-associated viruses from cynomolgus monkey: pseudotyping characterization of capsid protein

29 September 2017

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Gene therapy with novel adeno-associated virus vectors substantially diminishes atherosclerosis in a murine model of familial hypercholesterolemia

29 September 2017

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Clades of Adeno-associated viruses are widely disseminated in human tissues.

29 September 2017

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Structure of adeno-associated virus serotype 5.

29 September 2017

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Identification of a heparin-binding motif on adeno-associated virus type 2 capsids

29 September 2017

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Identification of amino acid residues in the capsid proteins of adeno-associated virus type 2 that contribute to heparan sulfate proteoglycan binding

29 September 2017

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Adeno-associated viruses undergo substantial evolution in primates during natural infections

29 September 2017

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Cross-packaging of a single adeno-associated virus (AAV) type 2 vector genome into multiple AAV serotypes enables transduction with broad specificity

29 September 2017

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Virus Particle Explorer (VIPER), a website for virus capsid structures and their computational analyses

29 September 2017

1 reference

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Binding of adeno-associated virus type 5 to 2,3-linked sialic acid is required for gene transfer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2168965

Monoclonal antibodies against the adeno-associated virus type 2 (AAV-2) capsid: epitope mapping and identification of capsid domains involved in AAV-2-cell interaction and neutralization of AAV-2 infection

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2168965

Adeno-associated virus-based vectors in gene therapy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2168965

Not your average density.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2168965

Prognostic significance of the 67-kilodalton laminin receptor expression in human breast carcinomas.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2168965

Adeno-associated virus vectors for gene therapy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2168965

A 33-kDa polypeptide with homology to the laminin receptor: component of translation machinery

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2168965

Interpretation of electron density with stereographic roadmap projections

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2168965

Separate basic region motifs within the adeno-associated virus capsid proteins are essential for infectivity and assembly

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2168965

Mutations on the external surfaces of adeno-associated virus type 2 capsids that affect transduction and neutralization

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2168965

A conformational change in the adeno-associated virus type 2 capsid leads to the exposure of hidden VP1 N termini

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2168965

Electron cryo-microscopy and image reconstruction of adeno-associated virus type 2 empty capsids

2 June 2018

1 reference

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Widespread and stable pancreatic gene transfer by adeno-associated virus vectors via different routes.

2 June 2018

1 reference

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Adeno-associated virus serotype 8 efficiently delivers genes to muscle and heart

27 November 2018

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Sustained correction of disease in naive and AAV2-pretreated hemophilia B dogs: AAV2/8-mediated, liver-directed gene therapy

27 November 2018

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Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous system

27 November 2018

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Total correction of hemophilia A mice with canine FVIII using an AAV 8 serotype.

27 November 2018

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Identification of a novel function for 67-kDa laminin receptor: increase in laminin degradation rate and release of motility fragments

27 November 2018

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Functional implications of the structure of the murine parvovirus, minute virus of mice

27 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2168965

Processing of X-ray diffraction data collected in oscillation mode

27 November 2018

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PubMed

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inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Overexpression of the 67-kD laminin receptor correlates with tumour progression in human colorectal carcinoma

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PubMed

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