Crystal structures of MMP-9 complexes with five inhibitors: contribution of the flexible Arg424 side-chain to selectivity (Q27646484)

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English	Crystal structures of MMP-9 complexes with five inhibitors: contribution of the flexible Arg424 side-chain to selectivity	scientific article

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Crystal structures of MMP-9 complexes with five inhibitors: contribution of the flexible Arg424 side-chain to selectivity (English)

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2

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Robert Huber

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3

object named as

Robert Huber

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Peter Goettig

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10

object named as

Peter Goettig

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Wolfram Bode

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9

object named as

Wolfram Bode

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author name string

Anna Tochowicz

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1

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Ruth Oltenfreiter

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4

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Vincent Dive

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5

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Athanasios Yiotakis

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6

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Matteo Zanda

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7

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Tayebeh Pourmotabbed

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8

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language of work or name

English

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publication date

24 August 2007

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published in

Journal of Molecular Biology

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volume

371

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issue

4

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page(s)

989-1006

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cites work

X-ray structure of a hydroxamate inhibitor complex of stromelysin catalytic domain and its comparison with members of the zinc metalloproteinase superfamily

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

Molecular Recognition of Protein−Ligand Complexes: Applications to Drug Design

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

Recent developments in the design of specific Matrix Metalloproteinase inhibitors aided by structural and computational studies

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

Matrix metalloproteinase inhibition attenuates early left ventricular enlargement after experimental myocardial infarction in mice

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

Matrix metalloproteinases: roles in cancer and metastasis

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

Synthesis of chiral 2-(4-phenoxyphenylsulfonylmethyl)thiiranes as selective gelatinase inhibitors

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

The structural basis for the elastolytic activity of the 92-kDa and 72-kDa gelatinases. Role of the fibronectin type II-like repeats

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

Future challenges facing the development of specific active-site-directed synthetic inhibitors of MMPs

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

Snapshots of the Reaction Mechanism of Matrix Metalloproteinases

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

Regulation of matrix biology by matrix metalloproteinases

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

Substrate hydrolysis by matrix metalloproteinase-9.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

PROCHECK: a program to check the stereochemical quality of protein structures

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

Structure of the C-terminally truncated human ProMMP9, a gelatin-binding matrix metalloproteinase

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

Cell surface association of matrix metalloproteinase-9 (gelatinase B).

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

Recent developments for the efficient crystallographic refinement of macromolecular structures

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

Crystal structure of the stromelysin-3 (MMP-11) catalytic domain complexed with a phosphinic inhibitor mimicking the transition-state

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

The design, structure, and therapeutic application of matrix metalloproteinase inhibitors

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

Partial purification and characterization of a neutral protease which cleaves type IV collagen

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

New functions for the matrix metalloproteinases in cancer progression

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

A novel rationale for inhibition of gelatinase B in multiple sclerosis: MMP-9 destroys alpha B-crystallin and generates a promiscuous T cell epitope.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

Inhibition of matrix metalloproteinase-9 by "multi-prong" surface binding groups

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

Structural basis of matrix metalloproteinases and tissue inhibitors of metalloproteinases

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

Inhibition of human prostate cancer growth, osteolysis and angiogenesis in a bone metastasis model by a novel mechanism-based selective gelatinase inhibitor

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

Crystal structures of matrilysin-inhibitor complexes

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

Activation of matrix metalloproteinase-9 (MMP-9) via a converging plasmin/stromelysin-1 cascade enhances tumor cell invasion

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

Matrix metalloproteinase inhibitors as anticancer therapeutics.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

A comparative docking study and the design of potentially selective MMP inhibitors

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

Inhibition of invasion, angiogenesis, tumor growth, and metastasis by adenovirus-mediated transfer of antisense uPAR and MMP-9 in non-small cell lung cancer cells.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

Structure of astacin with a transition-state analogue inhibitor

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

A residue in the S2 subsite controls substrate selectivity of matrix metalloproteinase-2 and matrix metalloproteinase-9.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

Structural basis for the highly selective inhibition of MMP-13.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

Antimetastatic activity of a novel mechanism-based gelatinase inhibitor

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

MOLREP: an Automated Program for Molecular Replacement

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9)

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

Recent advances in MMP inhibitor design

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

Matrix metalloproteinase-9 is required for adequate angiogenic revascularization of ischemic tissues: potential role in capillary branching.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

Matrix metalloproteinase-9 facilitates remyelination in part by processing the inhibitory NG2 proteoglycan

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

On the size of the active site in proteases. I. Papain

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

Solution structure of the loop B domain from the hairpin ribozyme

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

Angiogenesis extent and expression of matrix metalloproteinase-2 and -9 correlate with upgrading and myometrial invasion in endometrial carcinoma

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

Human thioredoxin reductase is efficiently inhibited by (2,2':6',2' '-terpyridine)platinum(II) complexes. Possible implications for a novel antitumor strategy

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

Pyrimidine-2,4,6-Triones: a new effective and selective class of matrix metalloproteinase inhibitors

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

Structure determination and analysis of human neutrophil collagenase complexed with a hydroxamate inhibitor

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

Matrix metalloproteinase-9 and autoimmune diseases

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

Evaluation of P1'-diversified phosphinic peptides leads to the development of highly selective inhibitors of MMP-11.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

Diastereoselective solution and multipin-based combinatorial array synthesis of a novel class of potent phosphinic metalloprotease inhibitors

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

Accurate bond and angle parameters for X-ray protein structure refinement

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

Structure and function of matrix metalloproteinases and TIMPs

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

Structure of human pro-matrix metalloproteinase-2: activation mechanism revealed

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

Towards third generation matrix metalloproteinase inhibitors for cancer therapy

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

X-ray structure of a novel matrix metalloproteinase inhibitor complexed to stromelysin

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

Tryptophane-based biphenylsulfonamide matrix metalloproteinase inhibitors as tumor imaging agents.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

Crystal structure of human MMP9 in complex with a reverse hydroxamate inhibitor

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

In bacterial meningitis cortical brain damage is associated with changes in parenchymal MMP-9/TIMP-1 ratio and increased collagen type IV degradation.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

Phosphinic pseudo-tripeptides as potent inhibitors of matrix metalloproteinases: a structure-activity study

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

Matrix metalloproteinase-9 from bone marrow-derived cells contributes to survival but not growth of tumor cells in the lung microenvironment

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

Structural implications for the role of the N terminus in the ‘superactivation’ of collagenases

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

Gelatinase B: a tuner and amplifier of immune functions.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

Cancer-associated glycoforms of gelatinase B exhibit a decreased level of binding to galectin-3.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

Effects of angiogenesis inhibitors on multistage carcinogenesis in mice

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

Crystal structure of an active form of human MMP-1.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

Purification of human collagenases with a hydroxamic acid affinity column

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

The fibronectin-like domain is required for the type V and XI collagenolytic activity of gelatinase B.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

Functional basis for the overlap in ligand interactions and substrate specificities of matrix metalloproteinases-9 and -2

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

Tumor targeting with a selective gelatinase inhibitor

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

A rationalization of the acidic pH dependence for stromelysin-1 (Matrix metalloproteinase-3) catalysis and inhibition

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

New radioiodinated carboxylic and hydroxamic matrix metalloproteinase inhibitor tracers as potential tumor imaging agents

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

X-ray structures of human neutrophil collagenase complexed with peptide hydroxamate and peptide thiol inhibitors. Implications for substrate binding and rational drug design

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

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1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.JMB.2007.05.068

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1 reference

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1 reference

11 October 2022

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10.1016/J.JMB.2007.05.068

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17599356

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ResearchGate publication ID

6238905

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Crystal structures of MMP-9 complexes with five inhibitors: contribution of the flexible Arg424 side-chain to selectivity (Q27646484)

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Crystal structures of MMP-9 complexes with five inhibitors: contribution of the flexible Arg424 side-chain to selectivity (Q27646484)

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