The HERG K+ channel: progress in understanding the molecular basis of its unusual gating kinetics (Q27642109)

Europe PubMed Central

title

The HERG K+ channel: progress in understanding the molecular basis of its unusual gating kinetics (English)

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author name string

Jamie I Vandenberg

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Allan M Torres

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Terence J Campbell

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Philip W Kuchel

European Biophysics Journal

4

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language of work or name

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April 2004

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published in

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volume

33

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issue

2

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page(s)

89-97

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exact match

https://scigraph.springernature.com/pub.10.1007/s00249-003-0338-3

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cites work

Agitoxin footprinting the shaker potassium channel pore.

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12 December 2020

Proton and zinc effects on HERG currents

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12 December 2020

Structural and functional role of the extracellular s5-p linker in the HERG potassium channel

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12 December 2020

A structural basis for drug-induced long QT syndrome

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Molecular determinants of dofetilide block of HERG K+ channels.

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12 December 2020

HERG K+ channels: friend and foe.

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Spatial localization of the K+ channel selectivity filter by mutant cycle-based structure analysis.

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12 December 2020

The moving parts of voltage-gated ion channels

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12 December 2020

Molecular determinants for activation and inactivation of HERG, a human inward rectifier potassium channel.

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12 December 2020

Two types of inactivation in Shaker K+ channels: effects of alterations in the carboxy-terminal region.

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12 December 2020

HERG, a human inward rectifier in the voltage-gated potassium channel family

1 reference

12 December 2020

Defective human Ether-à-go-go-related gene trafficking linked to an endoplasmic reticulum retention signal in the C terminus

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12 December 2020

Molecular and cellular mechanisms of cardiac arrhythmias

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12 December 2020

Spectrum of mutations in long-QT syndrome genes. KVLQT1, HERG, SCN5A, KCNE1, and KCNE2

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12 December 2020

The inward rectification mechanism of the HERG cardiac potassium channel

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12 December 2020

MOLMOL: a program for display and analysis of macromolecular structures

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12 December 2020

Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature

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12 December 2020

Solution structure of CnErg1 (Ergtoxin), a HERG specific scorpion toxin

1 reference

12 December 2020

A large number of novel Ergtoxin-like genes and ERG K+-channels blocking peptides from scorpions of the genus Centruroides.

1 reference

12 December 2020

Crystal structure and functional analysis of the HERG potassium channel N terminus: a eukaryotic PAS domain

1 reference

12 December 2020

Effects of outer mouth mutations on hERG channel function: a comparison with similar mutations in the Shaker channel

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12 December 2020

A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel

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12 December 2020

Analysis of the cyclic nucleotide binding domain of the HERG potassium channel and interactions with KCNE2

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12 December 2020

Revealing the architecture of a K+ channel pore through mutant cycles with a peptide inhibitor.

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12 December 2020

The open pore conformation of potassium channels

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12 December 2020

Mechanism for the effects of extracellular acidification on HERG-channel function.

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12 December 2020

Regulation of deactivation by an amino terminal domain in human ether-à-go-go-related gene potassium channels

1 reference

12 December 2020

Mapping the binding site of a human ether-a-go-go-related gene-specific peptide toxin (ErgTx) to the channel's outer vestibule

1 reference

12 December 2020

A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome

1 reference

12 December 2020

Mutations of the S4-S5 linker alter activation properties of HERG potassium channels expressed in Xenopus oocytes.

1 reference

12 December 2020

Novel mechanism of HERG current suppression in LQT2: shift in voltage dependence of HERG inactivation.

1 reference

12 December 2020

Protein rearrangements underlying slow inactivation of the Shaker K+ channel

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12 December 2020

MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia

1 reference

12 December 2020

Do glia have heart? Expression and functional role for ether-a-go-go currents in hippocampal astrocytes.

1 reference

12 December 2020

Channel-specific therapy of cardiac arrhythmias in our time?

1 reference

12 December 2020

ERG K+ channel blockade enhances firing and epinephrine secretion in rat chromaffin cells: the missing link to LQT2-related sudden death?

1 reference

12 December 2020

New binding site on common molecular scaffold provides HERG channel specificity of scorpion toxin BeKm-1

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12 December 2020

Energetics of pore opening in a voltage-gated K(+) channel

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12 December 2020

Fast and slow voltage sensor movements in HERG potassium channels

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12 December 2020

Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias

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12 December 2020

Long QT syndrome-associated mutations in the Per-Arnt-Sim (PAS) domain of HERG potassium channels accelerate channel deactivation.

1 reference

12 December 2020

Functional characterization of the C-terminus of the human ether-à-go-go-related gene K(+) channel (HERG).

1 reference

12 December 2020

Mutating a critical lysine in ShK toxin alters its binding configuration in the pore-vestibule region of the voltage-gated potassium channel, Kv1.3.

1 reference

12 December 2020

Glucose- and arginine-induced insulin secretion by human pancreatic beta-cells: the role of HERG K(+) channels in firing and release

1 reference

12 December 2020

PAS: a multifunctional domain family comes to light

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12 December 2020

Modulation of K+ current by frequency and external [K+]: a tale of two inactivation mechanisms.

1 reference

12 December 2020

The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity

1 reference

12 December 2020

Mutations in the hminK gene cause long QT syndrome and suppress IKs function

1 reference

12 December 2020

Pathways of HERG inactivation.

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12 December 2020

SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome

1 reference

12 December 2020

Effects of premature stimulation on HERG K(+) channels

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12 December 2020

Fast inactivation causes rectification of the IKr channel

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12 December 2020

The principle of gating charge movement in a voltage-dependent K+ channel

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12 December 2020

A family of potassium channel genes related to eag in Drosophila and mammals

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12 December 2020

A mutation in the pore region of HERG K+ channels expressed in Xenopus oocytes reduces rectification by shifting the voltage dependence of inactivation.

1 reference

12 December 2020

Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death

1 reference

12 December 2020

Negative charges in the transmembrane domains of the HERG K channel are involved in the activation- and deactivation-gating processes

1 reference

12 December 2020

Interactions between S4-S5 linker and S6 transmembrane domain modulate gating of HERG K+ channels

1 reference

12 December 2020

Cloning and functional characterization of the smooth muscle ether-a-go-go-related gene K+ channel. Potential role of a conserved amino acid substitution in the S4 region

1 reference

12 December 2020

Amino terminal-dependent gating of the potassium channel rat eag is compensated by a mutation in the S4 segment

1 reference

12 December 2020

Dynamic control of deactivation gating by a soluble amino-terminal domain in HERG K(+) channels

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12 December 2020

Gating currents from a nonconducting mutant reveal open-closed conformations in Shaker K+ channels

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12 December 2020

Voltage-sensing residues in the S2 and S4 segments of the Shaker K+ channel

1 reference

12 December 2020

Mutations within the P-loop of Kir6.2 modulate the intraburst kinetics of the ATP-sensitive potassium channel

1 reference

12 December 2020

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

1 reference

12 December 2020

I(Kr): the hERG channel

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12 December 2020

Temperature and pressure dependence of Shaker K+ channel N- and C-type inactivation.

1 reference

12 December 2020