Structural basis of BMP signalling inhibition by the cystine knot protein Noggin (Q27640149)

9

Juan Carlos Izpisua Belmonte

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Aris Economides

Aris N Economides

5

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Markus Affolter

Markus Affolter

7

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Senyon Choe

10

Senyon Choe

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Witek Kwiatkowski

6

Witek Kwiatkowski

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author name string

Jay Groppe

1

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Jason Greenwald

2

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Ezra Wiater

3

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Joaquin Rodriguez-Leon

4

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Wylie W Vale

TGF-beta signal transduction

8

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language of work or name

English

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publication date

12 December 2002

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published in

Nature

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volume

420

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page(s)

636-42

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issue

6916

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cites work

1 reference

TGF beta inhibitors. New and unexpected requirements in vertebrate development

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Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton

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Heterozygous mutations in the gene encoding noggin affect human joint morphogenesis

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Mutations of the NOG gene in individuals with proximal symphalangism and multiple synostosis syndrome

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Heparan sulfate proteoglycans retain Noggin at the cell surface: a potential mechanism for shaping bone morphogenetic protein gradients

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Three-dimensional structure of recombinant human osteogenic protein 1: structural paradigm for the transforming growth factor beta superfamily

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BMP-2 antagonists emerge from alterations in the low-affinity binding epitope for receptor BMPR-II

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Crystal structure of the BMP-2-BRIA ectodomain complex

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Identification of the ligand-binding site of the BMP type IA receptor for BMP-4

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BMP/GDF-signalling interactions during synovial joint development

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Bone morphogenetic protein signaling is required for maintenance of differentiated phenotype, control of proliferation, and hypertrophy in chondrocytes

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Human disease-causing NOG missense mutations: effects on noggin secretion, dimer formation, and bone morphogenetic protein binding

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Automated MAD and MIR structure solution

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Bi-cycling the furin pathway: from TGN localization to pathogen activation and embryogenesis

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Bone morphogenetic proteins: multifunctional regulators of vertebrate development

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Bone: formation by autoinduction

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Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos

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The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activities

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Dorsoventral patterning in Xenopus: inhibition of ventral signals by direct binding of chordin to BMP-4.

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The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4

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7 January 2021

Identical mutations in NOG can cause either tarsal/carpal coalition syndrome or proximal symphalangism

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7 January 2021

Noggin antagonizes BMP signaling to create a niche for adult neurogenesis

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7 January 2021

Induction of a noggin-like gene by ectopic DV interaction during planarian regeneration

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7 January 2021

Biochemical and biophysical characterization of refolded Drosophila DPP, a homolog of bone morphogenetic proteins 2 and 4.

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7 January 2021

Novel approach to phasing proteins: derivatization by short cryo-soaking with halides

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7 January 2021

Evolution and Classification of Cystine Knot-Containing Hormones and Related Extracellular Signaling Molecules

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7 January 2021

DAN is a secreted glycoprotein related to Xenopus cerberus.

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The cystine-knot growth-factor superfamily

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Endogenous and ectopic expression of noggin suggests a conserved mechanism for regulation of BMP function during limb and somite patterning.

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7 January 2021

Morphogenesis of digits in the avian limb is controlled by FGFs, TGFbetas, and noggin through BMP signaling

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Control of vertebrate limb outgrowth by the proximal factor Meis2 and distal antagonism of BMPs by Gremlin

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Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds.

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7 January 2021

Direct binding of follistatin to a complex of bone-morphogenetic protein and its receptor inhibits ventral and epidermal cell fates in early Xenopus embryo

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7 January 2021

Overexpression of BMP-2 and BMP-4 alters the size and shape of developing skeletal elements in the chick limb.

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7 January 2021

Requirement for BMP signaling in interdigital apoptosis and scale formation.

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7 January 2021

Identification of a novel NOG gene mutation (P35S) in an Italian family with symphalangism

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7 January 2021

Identification of mammalian noggin and its expression in the adult nervous system

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7 January 2021

Processing of X-ray diffraction data collected in oscillation mode

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7 January 2021

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

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7 January 2021

Multiple protein sequence alignment from tertiary structure comparison: assignment of global and residue confidence levels

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7 January 2021

Identifiers

DOI

10.1038/NATURE01245

1 reference

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

4126024

1014749240

0 references

4126024

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference