High resolution crystal structures of Siglec-7. Insights into ligand specificity in the Siglec family (Q27639982)

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15 December 2019

title

High resolution crystal structures of Siglec-7. Insights into ligand specificity in the Siglec family (English)

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15 December 2019

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3

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15 December 2019

Daan van Aalten

series ordinal

4

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15 December 2019

2

Helen Attrill

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15 December 2019

author name string

Magnus S Alphey

series ordinal

1

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15 December 2019

language of work or name

English

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publication date

15 November 2002

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Journal of Biological Chemistry

15 December 2019

number of pages

6

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based on heuristic

inferred from page(s)

published in

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15 December 2019

volume

278

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15 December 2019

issue

5

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15 December 2019

page(s)

3372-3377

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15 December 2019

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A new siglec family member, siglec-10, is expressed in cells of the immune system and has signaling properties similar to CD33.

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Sialic acid binding domains of CD22 are required for negative regulation of B cell receptor signaling

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The ligand-binding domain of CD22 is needed for inhibition of the B cell receptor signal, as demonstrated by a novel human CD22-specific inhibitor compound.

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Identification and characterization of a novel siglec, siglec-7, expressed by human natural killer cells and monocytes

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A small region of the natural killer cell receptor, Siglec-7, is responsible for its preferred binding to alpha 2,8-disialyl and branched alpha 2,6-sialyl residues. A comparison with Siglec-9.

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Processing of X-ray diffraction data collected in oscillation mode

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Free R value: a novel statistical quantity for assessing the accuracy of crystal structures

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Chinese hamster ovary cells selected for resistance to the cytotoxicity of phytohemagglutinin are deficient in a UDP-N-acetylglucosamine--glycoprotein N-acetylglucosaminyltransferase activity

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21 January 2018

Identifiers

DOI

10.1074/JBC.M210602200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12438315%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

1 reference