The crystal structure of human alpha1-tryptase reveals a blocked substrate-binding region (Q27639460)

4

object named as

Wolfram Bode

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author name string

Ulf Marquardt

1

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Frank Zettl

2

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Christian Sommerhoff

Journal of Molecular Biology

5

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language of work or name

English

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publication date

16 August 2002

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published in

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volume

321

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issue

3

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page(s)

491-502

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cites work

Cloning and characterization of complementary DNA for human tryptase

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900625-3

Characterization of genes encoding known and novel human mast cell tryptases on chromosome 16p13.3

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900625-3

Characterization of human gamma-tryptases, novel members of the chromosome 16p mast cell tryptase and prostasin gene families

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900625-3

Cloning and characterization of a second complementary DNA for human tryptase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900625-3

Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900625-3

Cloning of the human homolog of mouse transmembrane tryptase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900625-3

Identification of a new member of the tryptase family of mouse and human mast cell proteases which possesses a novel COOH-terminal hydrophobic extension

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900625-3

Localization of tryptase to human cutaneous mast cells and keratinocytes by immunofluorescence and immunoperoxidase cytochemistry with monoclonal antitryptase antibody

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900625-3

A novel heparin-dependent processing pathway for human tryptase. Autocatalysis followed by activation with dipeptidyl peptidase I.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900625-3

Pericellular substrates of human mast cell tryptase: 72,000 dalton gelatinase and fibronectin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900625-3

Human mast cell tryptase isoforms: separation and examination of substrate-specificity differences

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900625-3

Reaction of mast cell proteases tryptase and chymase with protease activated receptors (PARs) on keratinocytes and fibroblasts.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900625-3

Mast cell tryptase potentiates histamine-induced contraction in human sensitized bronchus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900625-3

Definition of the extended substrate specificity determinants for beta-tryptases I and II.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900625-3

Mammalian tissue trypsin-like enzymes: substrate specificity and inhibitory potency of substituted isocoumarin mechanism-based inhibitors, benzamidine derivatives, and arginine fluoroalkyl ketone transition-state inhibitors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900625-3

The structure of the human betaII-tryptase tetramer: fo(u)r better or worse

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900625-3

Human beta-tryptase is a ring-like tetramer with active sites facing a central pore

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900625-3

The alpha form of human tryptase is the predominant type present in blood at baseline in normal subjects and is elevated in those with systemic mastocytosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900625-3

Elevated serum tryptase in exercise-induced anaphylaxis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900625-3

The potential clinical utility of serum alpha-protryptase levels

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900625-3

Human tryptases alpha and beta/II are functionally distinct due, in part, to a single amino acid difference in one of the surface loops that forms the substrate-binding cleft

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900625-3

Activation, activity and inhibition of bovine trypsin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900625-3

Formation of enzymatically active, homotypic, and heterotypic tetramers of mouse mast cell tryptases. Dependence on a conserved Trp-rich domain on the surface.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900625-3

The three-dimensional structure of recombinant leech-derived tryptase inhibitor in complex with trypsin. Implications for the structure of human mast cell tryptase and its inhibition

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900625-3

Human leukocyte and porcine pancreatic elastase: X-ray crystal structures, mechanism, substrate specificity, and mechanism-based inhibitors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900625-3

The transition of bovine trypsinogen to a trypsin-like state upon strong ligand binding. II. The binding of the pancreatic trypsin inhibitor and of isoleucine-valine and of sequentially related peptides to trypsinogen and to p-guanidinobenzoate-tryp

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900625-3

Diverse stability and catalytic properties of human tryptase alpha and beta isoforms are mediated by residue differences at the S1 pocket

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900625-3

Secretory granule proteases in rat mast cells. Cloning of 10 different serine proteases and a carboxypeptidase A from various rat mast cell populations

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900625-3

The human mast cell tryptase tetramer: a fascinating riddle solved by structure

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900625-3

Bivalent inhibition of human beta-tryptase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900625-3

Dibasic inhibitors of human mast cell tryptase. Part 2: structure-activity relationships and requirements for potent activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900625-3

Dibasic inhibitors of human mast cell tryptase. Part 1: synthesis and optimization of a novel class of inhibitors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900625-3

Solvent content of protein crystals

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900625-3

On the use of strong Patterson function signals in many-body molecular replacement.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900625-3

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900625-3

Cross-validated maximum likelihood enhances crystallographic simulated annealing refinement

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900625-3

Accurate bond and angle parameters for X-ray protein structure refinement

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900625-3

Validation of protein models derived from experiment.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900625-3

Conformation of Polypeptides and Proteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900625-3

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900625-3

Raster3D: photorealistic molecular graphics

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900625-3

Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900625-3

ALSCRIPT: a tool to format multiple sequence alignments

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900625-3

10.1016/S0022-2836(02)00625-3

7 January 2021

Identifiers

DOI

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Fatcat ID

release_vld5b57fengmzk5kdimxjzlciq

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Fatcat

https://api.fatcat.wiki/v0/release/vld5b57fengmzk5kdimxjzlciq