Molecular architecture and functional model of the endocytic AP2 complex (Q27639261)

GOA release 2020-03-11

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GOA release 2020-03-11

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Airlie J McCoy

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author name string

Brett M Collins

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Helen M Kent

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Philip R Evans

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David J Owen

Methods used in the structure determination of bovine mitochondrial F1 ATPase

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publication date

17 May 2002

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language of work or name

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109

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issue

4

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page(s)

523-35

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cites work

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Biological Basket Weaving: Formation and Function of Clathrin-Coated Vesicles

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Adaptor self-aggregation, adaptor-receptor recognition and binding of alpha-adaptin subunits to the plasma membrane contribute to recruitment of adaptor (AP2) components of clathrin-coated pits

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Identification of an adaptor-associated kinase, AAK1, as a regulator of clathrin-mediated endocytosis

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Essential role of phosphoinositide metabolism in synaptic vesicle recycling

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Improved R-factors for diffraction data analysis in macromolecular crystallography

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The actin-binding protein Hip1R associates with clathrin during early stages of endocytosis and promotes clathrin assembly in vitro

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7 January 2021

Binding of AP2 to sorting signals is modulated by AP2 phosphorylation

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Simultaneous binding of PtdIns(4,5)P2 and clathrin by AP180 in the nucleation of clathrin lattices on membranes

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Phosphoinositide-AP-2 interactions required for targeting to plasma membrane clathrin-coated pits

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7 January 2021

A functional phosphatidylinositol 3,4,5-trisphosphate/phosphoinositide binding domain in the clathrin adaptor AP-2 alpha subunit. Implications for the endocytic pathway

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The class II phosphoinositide 3-kinase C2alpha is activated by clathrin and regulates clathrin-mediated membrane trafficking

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Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells

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7 January 2021

A novel snare N-terminal domain revealed by the crystal structure of Sec22b

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7 January 2021

Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptor

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7 January 2021

Direct interaction of the 170 kDa isoform of synaptojanin 1 with clathrin and with the clathrin adaptor AP-2

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7 January 2021

Deep-etch visualization of proteins involved in clathrin assembly

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7 January 2021

Structural Basis for Control by Phosphorylation

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Phosphatidylinositol-4,5-bisphosphate is required for endocytic coated vesicle formation

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7 January 2021

Clathrin-coated vesicles: Isolation, dissociation and factor-dependent reassociation of clathrin baskets

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7 January 2021

Adaptors for clathrin-mediated traffic

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Structural and functional division into two domains of the large (100- to 115-kDa) chains of the clathrin-associated protein complex AP-2

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7 January 2021

The pleckstrin homology domain of oxysterol-binding protein recognises a determinant specific to Golgi membranes.

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7 January 2021

The crystal structure of a phosphorylase kinase peptide substrate complex: kinase substrate recognition

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7 January 2021

Stabilization of clathrin coats by the core of the clathrin-associated protein complex AP-2.

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7 January 2021

mu1A-adaptin-deficient mice: lethality, loss of AP-1 binding and rerouting of mannose 6-phosphate receptors

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7 January 2021

Uncoating of clathrin-coated vesicles in presynaptic terminals: roles for Hsc70 and auxilin

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7 January 2021

Refinement of macromolecular structures by the maximum-likelihood method

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7 January 2021

Inhibition of the receptor-binding function of clathrin adaptor protein AP-2 by dominant-negative mutant mu2 subunit and its effects on endocytosis

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7 January 2021

Interaction of tyrosine-based sorting signals with clathrin-associated proteins

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7 January 2021

Phosphorylation of threonine 156 of the mu2 subunit of the AP2 complex is essential for endocytosis in vitro and in vivo

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7 January 2021

A structural explanation for the recognition of tyrosine-based endocytotic signals

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7 January 2021

A structural explanation for the binding of multiple ligands by the alpha-adaptin appendage domain

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7 January 2021

The structure and function of the beta 2-adaptin appendage domain

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A third specificity-determining site in mu 2 adaptin for sequences upstream of Yxx phi sorting motifs

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7 January 2021

Targeting signals and subunit interactions in coated vesicle adaptor complexes

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7 January 2021

The 50 kDa protein subunit of assembly polypeptide (AP) AP-2 adaptor from clathrin-coated vesicles is phosphorylated on threonine-156 by AP-1 and a soluble AP50 kinase which co-purifies with the assembly polypeptides

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7 January 2021

Coated vesicles from pig brain: Purification and biochemical characterization

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7 January 2021

Assembly and function of AP-3 complexes in cells expressing mutant subunits.

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7 January 2021

Cluster of differentiation antigen 4 (CD4) endocytosis and adaptor complex binding require activation of the CD4 endocytosis signal by serine phosphorylation

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7 January 2021

Regulatory interactions in the recognition of endocytic sorting signals by AP-2 complexes

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7 January 2021

Dileucine-based sorting signals bind to the beta chain of AP-1 at a site distinct and regulated differently from the tyrosine-based motif-binding site

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7 January 2021

Phosphorylation of the AP2 mu subunit by AAK1 mediates high affinity binding to membrane protein sorting signals

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7 January 2021

100-kD coated vesicle proteins: molecular heterogeneity and intracellular distribution studied with monoclonal antibodies

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7 January 2021

Medium Chains of Adaptor Complexes AP-1 and AP-2 Recognize Leucine-based Sorting Signals from the Invariant Chain

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7 January 2021

The targeting of Lamp1 to lysosomes is dependent on the spacing of its cytoplasmic tail tyrosine sorting motif relative to the membrane

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7 January 2021

The role of phosphoinositides in membrane transport

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7 January 2021

Peptide-in-groove interactions link target proteins to the beta-propeller of clathrin

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7 January 2021

An autoinhibitory mechanism for nonsyntaxin SNARE proteins revealed by the structure of Ykt6p

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7 January 2021

Clathrin-associated adaptor proteins - putting it all together.

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7 January 2021

Crystal structure of the alpha appendage of AP-2 reveals a recruitment platform for clathrin-coat assembly

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7 January 2021

Identification of the universal cofactor (auxilin 2) in clathrin coat dissociation

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7 January 2021

CTLA-4 can function as a negative regulator of T cell activation

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7 January 2021

In vivo phosphorylation of adaptors regulates their interaction with clathrin

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7 January 2021

Limited proteolytic digestion of coated vesicle assembly polypeptides abolishes reassembly activity

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7 January 2021