Mitogen-activated protein kinase kinase PBS2 YJL128C (Q27547665)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P08018

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine/threonine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Saccharomyces cerevisiae S288c

1 reference

25 May 2022

1 reference

25 May 2022

MAP kinase kinase activity

ISS

transferase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08018

1 reference

9 May 2019

kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08018

1 reference

9 May 2019

protein tyrosine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08018

1 reference

9 May 2019

MAP-kinase scaffold activity

3 references

9 May 2019

Sho1 and Pbs2 act as coscaffolds linking components in the yeast high osmolarity MAP kinase pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08018

9 May 2019

Protein-protein interaction affinity plays a crucial role in controlling the Sho1p-mediated signal transduction pathway in yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08018

9 May 2019

Osmotic activation of the HOG MAPK pathway via Ste11p MAPKKK: scaffold role of Pbs2p MAPKK.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08018

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08018

1 reference

9 May 2019

peptide alpha-N-acetyltransferase activity

1 reference

9 May 2019

Nat3p and Mdm20p are required for function of yeast NatB Nalpha-terminal acetyltransferase and of actin and tropomyosin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08018

protein kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08018&geneProductId=UniProtKB:P08018

1 reference

10 September 2018

protein binding

9 references

9 May 2019

Nat3p and Mdm20p are required for function of yeast NatB Nalpha-terminal acetyltransferase and of actin and tropomyosin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08018

9 May 2019

Nbp2 targets the Ptc1-type 2C Ser/Thr phosphatase to the HOG MAPK pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08018

9 May 2019

Osmotic activation of the HOG MAPK pathway via Ste11p MAPKKK: scaffold role of Pbs2p MAPKK.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08018

9 May 2019

Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08018

9 May 2019

Optimization of specificity in a cellular protein interaction network by negative selection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08018

9 May 2019

Bayesian modeling of the yeast SH3 domain interactome predicts spatiotemporal dynamics of endocytosis proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08018

9 May 2019

Sho1p connects the plasma membrane with proteins of the cytokinesis network via multiple isomeric interaction states

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08018

9 May 2019

Protein interaction networks by proteome peptide scanning

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08018

9 May 2019

A combined experimental and computational strategy to define protein interaction networks for peptide recognition modules

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08018

MAP kinase kinase activity

An osmosensing signal transduction pathway in yeast.

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08018

ISS

9 May 2019

Activation of yeast PBS2 MAPKK by MAPKKKs or by binding of an SH3-containing osmosensor.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08018

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08018

cell component

cellular bud neck

1 reference

9 May 2019

Polarized localization of yeast Pbs2 depends on osmostress, the membrane protein Sho1 and Cdc42.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08018

cellular bud tip

1 reference

9 May 2019

Polarized localization of yeast Pbs2 depends on osmostress, the membrane protein Sho1 and Cdc42.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08018

cytoplasmic stress granule

1 reference

9 May 2019

ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08018

NatB complex

1 reference

9 May 2019

Nat3p and Mdm20p are required for function of yeast NatB Nalpha-terminal acetyltransferase and of actin and tropomyosin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08018

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08018

3 references

9 May 2019

9 May 2019

Regulated nucleo/cytoplasmic exchange of HOG1 MAPK requires the importin beta homologs NMD5 and XPO1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08018

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08018

biological process

protein phosphorylation

Osmostress-induced transcription by Hot1 depends on a Hog1-mediated recruitment of the RNA Pol II.

5 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08018&geneProductId=UniProtKB:P08018

10 September 2018

Activation of yeast PBS2 MAPKK by MAPKKKs or by binding of an SH3-containing osmosensor.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08018&geneProductId=UniProtKB:P08018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08018&geneProductId=UniProtKB:P08018

10 September 2018

10 September 2018

An osmosensing signal transduction pathway in yeast.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08018&geneProductId=UniProtKB:P08018

10 September 2018

Osmostress-induced transcription by Hot1 depends on a Hog1-mediated recruitment of the RNA Pol II.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08018&geneProductId=UniProtKB:P08018

cellular response to heat

1 reference

9 May 2019

Heat stress activates the yeast high-osmolarity glycerol mitogen-activated protein kinase pathway, and protein tyrosine phosphatases are essential under heat stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08018

response to antibiotic

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08018

1 reference

9 May 2019

actin filament organization

1 reference

9 May 2019

Positioning of cell growth and division after osmotic stress requires a MAP kinase pathway.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08018

phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08018

1 reference

9 May 2019

hyperosmotic response

1 reference

9 May 2019

An osmosensing signal transduction pathway in yeast.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08018

peptidyl-tyrosine phosphorylation

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08018

regulation of mitotic cell cycle

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08018&geneProductId=UniProtKB:P08018

1 reference

27 February 2018

stress-activated protein kinase signaling cascade

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08018

regulation of apoptotic process

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08018&geneProductId=UniProtKB:P08018

1 reference

27 February 2018

MAPK cascade

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08018

protein import into nucleus

1 reference

9 May 2019

Evidence that C-terminal non-kinase domain of Pbs2p has a role in high osmolarity-induced nuclear localization of Hog1p

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08018

signal transduction

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08018

activation of protein kinase activity

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08018

cellular hyperosmotic response

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08018

protein phosphorylation

Activation of yeast PBS2 MAPKK by MAPKKKs or by binding of an SH3-containing osmosensor.

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08018

9 May 2019

Osmostress-induced transcription by Hot1 depends on a Hog1-mediated recruitment of the RNA Pol II.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08018

9 May 2019

9 May 2019

An osmosensing signal transduction pathway in yeast.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08018

9 May 2019

Osmostress-induced transcription by Hot1 depends on a Hog1-mediated recruitment of the RNA Pol II.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08018

9 May 2019

Global analysis of protein phosphorylation in yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08018

serine/threonine-protein kinase, active site

HDA

has part(s)

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P08018

protein kinase domain

1 reference

InterPro Release 71.0