Xrs2p YDR369C (Q27547391)

http://www.ebi.ac.uk/interpro/protein/P33301

Forkhead-associated (FHA) domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Saccharomyces cerevisiae S288c

1 reference

25 May 2022

1 reference

25 May 2022

single-stranded telomeric DNA binding

1 reference

14 February 2019

The characterization of Saccharomyces cerevisiae Mre11/Rad50/Xrs2 complex reveals that Rad50 negatively regulates Mre11 endonucleolytic but not the exonucleolytic activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33301

Late S phase-specific recruitment of Mre11 complex triggers hierarchical assembly of telomere replication proteins in Saccharomyces cerevisiae.

telomeric DNA binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33301

The characterization of Saccharomyces cerevisiae Mre11/Rad50/Xrs2 complex reveals that Rad50 negatively regulates Mre11 endonucleolytic but not the exonucleolytic activity

G-quadruplex DNA binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33301

1 reference

14 February 2019

Yeast Xrs2 Binds DNA and Helps Target Rad50 and Mre11 to DNA Ends

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33301

protein-macromolecule adaptor activity

1 reference

14 February 2019

Yeast Xrs2 Binds DNA and Helps Target Rad50 and Mre11 to DNA Ends

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33301

double-stranded telomeric DNA binding

1 reference

14 February 2019

The characterization of Saccharomyces cerevisiae Mre11/Rad50/Xrs2 complex reveals that Rad50 negatively regulates Mre11 endonucleolytic but not the exonucleolytic activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33301

10 references

14 February 2019

Structure of Mre11–Nbs1 complex yields insights into ataxia-telangiectasia–like disease mutations and DNA damage signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33301

14 February 2019

Tel1 and Rif2 Regulate MRX Functions in End-Tethering and Repair of DNA Double-Strand Breaks

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33301

14 February 2019

Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33301

14 February 2019

Sae2 promotes dsDNA endonuclease activity within Mre11-Rad50-Xrs2 to resect DNA breaks

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33301

14 February 2019

DNA end recognition by the Mre11 nuclease dimer: insights into resection and repair of damaged DNA.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33301

14 February 2019

Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33301

14 February 2019

Proteome-wide protein interaction measurements of bacterial proteins of unknown function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33301

14 February 2019

Complex formation and functional versatility of Mre11 of budding yeast in recombination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33301

14 February 2019

The Rad50 coiled-coil domain is indispensable for Mre11 complex functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33301

14 February 2019

Antiviral protein Ski8 is a direct partner of Spo11 in meiotic DNA break formation, independent of its cytoplasmic role in RNA metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33301

1 reference

14 February 2019

Complex formation and functional versatility of Mre11 of budding yeast in recombination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33301

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33301

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33301

meiotic DNA double-strand break formation

IEA

1 reference

14 February 2019

Xrs2p regulates Mre11p translocation to the nucleus and plays a role in telomere elongation and meiotic recombination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33301

sporulation resulting in formation of a cellular spore

1 reference

14 February 2019

Xrs2p regulates Mre11p translocation to the nucleus and plays a role in telomere elongation and meiotic recombination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33301

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33301

2 references

mitochondrial double-strand break repair via homologous recombination

1 reference

14 February 2019

Mitochondrial genome maintenance: roles for nuclear nonhomologous end-joining proteins in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33301

cellular response to DNA damage stimulus

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33301

double-strand break repair via nonhomologous end joining

IEA

maintenance of DNA trinucleotide repeats

1 reference

14 February 2019

The Saccharomyces cerevisiae Mre11-Rad50-Xrs2 complex promotes trinucleotide repeat expansions independently of homologous recombination.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33301

forkhead-associated (FHA) domain

has part(s)

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P33301

Identifiers

1 reference

20 March 2022

1 reference

25 May 2022

1 reference