Physiological notch signaling maintains bone homeostasis via RBPjk and Hey upstream of NFATc1 (Q27334560)

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27 January 2020

title

Physiological notch signaling maintains bone homeostasis via RBPjk and Hey upstream of NFATc1 (English)

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27 January 2020

8

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27 January 2020

Raphael Kopan

9

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27 January 2020

Manfred Gessler

10

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27 January 2020

author name string

Xiaolin Tu

1

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27 January 2020

Jianquan Chen

2

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27 January 2020

Joohyun Lim

3

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27 January 2020

Courtney M Karner

4

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27 January 2020

Seung-Yon Lee

5

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27 January 2020

Julia Heisig

6

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27 January 2020

Cornelia Wiese

7

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27 January 2020

Fanxin Long

11

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27 January 2020

language of work or name

English

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publication date

22 March 2012

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27 January 2020

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27 January 2020

volume

8

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27 January 2020

issue

3

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27 January 2020

page(s)

e1002577

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Creative Commons Attribution 4.0 International

27 January 2020

copyright license

start time

22 March 2012

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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HES and HERP families: multiple effectors of the Notch signaling pathway

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Axial skeletal defects caused by mutation in the spondylocostal dysplasia/pudgy gene Dll3 are associated with disruption of the segmentation clock within the presomitic mesoderm

21 March 2017

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Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

21 March 2017

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Skeletal and CNS defects in Presenilin-1-deficient mice

21 March 2017

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Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition

21 March 2017

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Notch1 and 2 cooperate in limb ectoderm to receive an early Jagged2 signal regulating interdigital apoptosis

21 March 2017

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gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis

21 March 2017

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The Notch target genes Hey1 and Hey2 are required for embryonic vascular development

21 March 2017

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Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice

21 March 2017

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Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

21 March 2017

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The canonical Notch signaling pathway: unfolding the activation mechanism

21 March 2017

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A global map of p53 transcription-factor binding sites in the human genome

7 April 2017

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Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts

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Canonical and non-canonical Notch ligands

29 September 2017

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Osteosclerosis owing to Notch gain of function is solely Rbpj-dependent

29 September 2017

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RBPjkappa-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development

29 September 2017

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The contribution of Notch1 to nephron segmentation in the developing kidney is revealed in a sensitized Notch2 background and can be augmented by reducing Mint dosage.

29 September 2017

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NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism

29 September 2017

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29 September 2017

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29 September 2017

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Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation

29 September 2017

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29 September 2017

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Osteoblast-derived PTHrP is a potent endogenous bone anabolic agent that modifies the therapeutic efficacy of administered PTH 1-34.

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation

29 September 2017

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A common enzyme connects notch signaling and Alzheimer's disease

29 September 2017

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The nuclear factor of activated T cells (NFAT) transcription factor NFATp (NFATc2) is a repressor of chondrogenesis

29 September 2017

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Epidermal Notch1 loss promotes skin tumorigenesis by impacting the stromal microenvironment.

29 September 2017

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2 June 2018

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Autoregulation of NFATc1/A expression facilitates effector T cells to escape from rapid apoptosis

2 June 2018

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2 June 2018

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2 June 2018

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Calcineurin/NFAT signaling in osteoblasts regulates bone mass

2 June 2018

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Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors.

21 January 2018

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NOTCH1 regulates osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblast lineage cells.

21 January 2018

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Ubiquitous overexpression of Hey1 transcription factor leads to osteopenia and chondrocyte hypertrophy in bone

21 January 2018

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Differential Notch signalling distinguishes neural stem cells from intermediate progenitors.

21 January 2018

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Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron.

21 January 2018

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Generation of new Notch2 mutant alleles.

21 January 2018

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Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1.

21 January 2018

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Novel missense mutations (p.T596M and p.P1797H) in NOTCH1 in patients with bicuspid aortic valve

21 January 2018

1 reference

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Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22457635

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Expression of Cre recombinase in the developing mouse limb bud driven by aPrxl enhancer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22457635

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PGEN.1002577

2 references

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27 January 2020

1 reference

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27 January 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22457635%20AND%20SRC:MED&resulttype=core&format=json