Mathematical modeling of herpes simplex virus-2 suppression with pritelivir predicts trial outcomes (Q27324453)

26 June 2017

Mathematical modeling of herpes simplex virus-2 suppression with pritelivir predicts trial outcomes (English)

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26 June 2017

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Lawrence Corey

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Anna Wald

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26 June 2017

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Amalia Magaret

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Joshua T Schiffer

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David A Swan

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Helga Ruebsamen-Schaeff

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object named as

Helga Ruebsamen-Schaeff

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Susanne Stoelben

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Burkhard Timmler

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Alexander Birkmann

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Scott A Van Wart

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Joachim Ossig

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26 June 2017

Holger Zimmermann

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Murad R Melhem

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Christopher M Rubino

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language of work or name

English

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publication date

1 February 2016

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Science Translational Medicine

26 June 2017

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26 June 2017

324ra15

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26 June 2017

324

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Virologic characteristics of subclinical and symptomatic genital herpes infections

26 June 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880060

Pharmacokinetics and pharmacodynamics of the reverse transcriptase inhibitor tenofovir and prophylactic efficacy against HIV-1 infection

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880060

Two-drug antimicrobial chemotherapy: a mathematical model and experiments with Mycobacterium marinum

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880060

HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880060

Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880060

Herpes simplex virus-2 genital tract shedding is not predictable over months or years in infected persons

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880060

Rapid viral expansion and short drug half-life explain the incomplete effectiveness of current herpes simplex virus 2-directed antiviral agents

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880060

Mucosal HSV-2 Specific CD8+ T-Cells Represent Containment of Prior Viral Shedding Rather than a Correlate of Future Protection

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880060

Antiretroviral dynamics determines HIV evolution and predicts therapy outcome

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880060

Standard-dose and high-dose daily antiviral therapy for short episodes of genital HSV-2 reactivation: three randomised, open-label, cross-over trials

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880060

Detailed analysis of mucosal herpes simplex virus-2 replication kinetics with and without antiviral therapy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880060

The kinetics of mucosal herpes simplex virus-2 infection in humans: evidence for rapid viral-host interactions

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880060

Rapidly cleared episodes of oral and anogenital herpes simplex virus shedding in HIV-infected adults

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880060

Frequent release of low amounts of herpes simplex virus from neurons: results of a mathematical model

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880060

A novel method for determining the inhibitory potential of anti-HIV drugs

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880060

Rapidly cleared episodes of herpes simplex virus reactivation in immunocompetent adults

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880060

Optimizing PCR positivity criterion for detection of herpes simplex virus DNA on skin and mucosa

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880060

New helicase-primase inhibitors as drug candidates for the treatment of herpes simplex disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880060

Frequent genital herpes simplex virus 2 shedding in immunocompetent women. Effect of acyclovir treatment

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880060

Helicase-primase inhibitor pritelivir for HSV-2 infection

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880060

Baseline sensitivity of HSV-1 and HSV-2 clinical isolates and defined acyclovir-resistant strains to the helicase-primase inhibitor pritelivir

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880060

Assessing the impact of adherence to anti-retroviral therapy on treatment failure and resistance evolution in HIV.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4880060

Rapid localized spread and immunologic containment define Herpes simplex virus-2 reactivation in the human genital tract

2 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD6654

10.1126/SCITRANSLMED.AAD6654

21 January 2018

Identifiers

DOI

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26 June 2017

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