High-content chemical and RNAi screens for suppressors of neurotoxicity in a Huntington's disease model (Q27323092)

2

0 references

Chaohong Wu

3

0 references

Pengyu Hong

4

0 references

J Troy Littleton

Creative Commons Attribution 4.0 International

5

0 references

language of work or name

English

0 references

publication date

2011

0 references

published in

PLOS One

0 references

volume

6

0 references

issue

8

0 references

page(s)

e23841

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copyright license

start time

31 August 2011

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Cerebral cortex structure in prodromal Huntington disease

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Striatal and white matter predictors of estimated diagnosis for Huntington disease

28 September 2017

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Mutant huntingtin in glial cells exacerbates neurological symptoms of Huntington disease mice

28 September 2017

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A genomewide RNA interference screen for modifiers of aggregates formation by mutant Huntingtin in Drosophila

28 September 2017

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RNAi screening in Drosophila cells identifies new modifiers of mutant huntingtin aggregation

28 September 2017

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Inactivation of Drosophila Huntingtin affects long-term adult functioning and the pathogenesis of a Huntington's disease model

28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity

28 September 2017

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28 September 2017

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Identification of combinatorial drug regimens for treatment of Huntington's disease using Drosophila.

28 September 2017

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Benefit-risk assessment of sirolimus in renal transplantation

28 September 2017

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A potent small molecule inhibits polyglutamine aggregation in Huntington's disease neurons and suppresses neurodegeneration in vivo

28 September 2017

1 reference

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Dysregulation of the TSC-mTOR pathway in human disease

28 September 2017

1 reference

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Mitochondrial proliferation during apoptosis induced by anticancer agents: effects of doxorubicin and mitoxantrone on cancer and cardiac cells.

28 September 2017

1 reference

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Sirolimus-associated pulmonary toxicity

28 September 2017

1 reference

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Huntingtin-protein interactions and the pathogenesis of Huntington's disease

28 September 2017

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Camptothecin: current perspectives

28 September 2017

1 reference

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Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166080

Cytoplasmic aggregates trap polyglutamine-containing proteins and block axonal transport in a Drosophila model of Huntington's disease.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166080

A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166080

Changes of mitochondrial mass in the hemopoietic stem cell line FDCP-mix after treatment with etoposide: a correlative study by multiparameter flow cytometry and confocal and electron microscopy.

28 September 2017

1 reference

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Automatic robust neurite detection and morphological analysis of neuronal cell cultures in high-content screening

28 September 2017

1 reference

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Preventing neurodegeneration in the Drosophila mutant bubblegum

31 May 2018

1 reference

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Drosophila neuroligin 1 promotes growth and postsynaptic differentiation at glutamatergic neuromuscular junctions

31 May 2018

1 reference

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Neuroprotective effects of glycyrrhizic acid and 18beta-glycyrrhetinic acid in PC12 cells via modulation of the PI3K/Akt pathway

27 November 2018

1 reference

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Genomewide linkage scan reveals novel loci modifying age of onset of Huntington's disease in the Venezuelan HD kindreds

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166080

Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166080

JNK pathway mediates apoptotic cell death induced by tumor suppressor LKB1 in Drosophila

27 November 2018

1 reference

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Pathological cell-cell interactions elicited by a neuropathogenic form of mutant Huntingtin contribute to cortical pathogenesis in HD mice.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166080

Glial and neuronal expression of polyglutamine proteins induce behavioral changes and aggregate formation in Drosophila.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166080

The c-Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK-ERK and Akt-independent mechanism

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166080

Progressive decrease in chaperone protein levels in a mouse model of Huntington's disease and induction of stress proteins as a therapeutic approach

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166080

Mechanisms of caspase-independent neuronal death: energy depletion and free radical generation.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166080

Disruption of Axonal Transport by Loss of Huntingtin or Expression of Pathogenic PolyQ Proteins in Drosophila

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166080

Pharmacological prevention of Parkinson disease in Drosophila.

27 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166080

Effects of sirolimus on plasma lipids, lipoprotein levels, and fatty acid metabolism in renal transplant patients.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166080

Early and progressive accumulation of reactive microglia in the Huntington disease brain

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166080

A putative Drosophila homolog of the Huntington's disease gene

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166080

Gap-junction-mediated propagation and amplification of cell injury.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166080

Axonal transport of N-terminal huntingtin suggests early pathology of corticostriatal projections in Huntington disease

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3166080

Regional specificity of brain atrophy in Huntington's disease.

27 November 2018

1 reference

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Irreversible trapping of the DNA-topoisomerase I covalent complex. Affinity labeling of the camptothecin binding site

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21909362

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Neither LKB1 nor AMPK are the direct targets of metformin

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21909362

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

High sirolimus levels may induce focal segmental glomerulosclerosis de novo

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21909362