Vascular disease-causing mutation R258C in ACTA2 disrupts actin dynamics and interaction with myosin (Q27322453)

26 June 2017

Vascular disease-causing mutation R258C in ACTA2 disrupts actin dynamics and interaction with myosin (English)

1 reference

26 June 2017

Hailong Lu

1

1 reference

26 June 2017

Patricia M Fagnant

2

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26 June 2017

Carol S Bookwalter

3

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26 June 2017

Peteranne Joel

4

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26 June 2017

Kathleen M Trybus

5

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26 June 2017

language of work or name

English

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publication date

7 July 2015

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Proceedings of the National Academy of Sciences of the United States of America

26 June 2017

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26 June 2017

112

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26 June 2017

31

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26 June 2017

E4168-77

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describes a project that uses

26 June 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4534267/fullTextXML

inferred from PubMed Central ID database lookup

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Mutations in smooth muscle alpha-actin (ACTA2) cause coronary artery disease, stroke, and Moyamoya disease, along with thoracic aortic disease

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Rare, nonsynonymous variant in the smooth muscle-specific isoform of myosin heavy chain, MYH11, R247C, alters force generation in the aorta and phenotype of smooth muscle cells

28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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The mouse formin, FRLalpha, slows actin filament barbed end elongation, competes with capping protein, accelerates polymerization from monomers, and severs filaments

28 September 2017

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28 September 2017

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R403Q and L908V mutant beta-cardiac myosin from patients with familial hypertrophic cardiomyopathy exhibit enhanced mechanical performance at the single molecule level

28 September 2017

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28 September 2017

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28 September 2017

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A novel system for expressing toxic actin mutants in Dictyostelium and purification and characterization of a dominant lethal yeast actin mutant.

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Activation of the Arp2/3 complex by N-WASp is required for actin polymerization and contraction in smooth muscle

21 January 2018

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Contractility-dependent actin dynamics in cardiomyocyte sarcomeres.

21 January 2018

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Mutation of ACTA2 gene as an important cause of familial and nonfamilial nonsyndromatic thoracic aortic aneurysm and/or dissection (TAAD)

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12 December 2020

Uncoupling actin filament fragmentation by cofilin from increased subunit turnover

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12 December 2020

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Identifiers

DOI

10.1073/PNAS.1507587112

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26 June 2017

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