Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance (Q27319398)

26 June 2017

Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance (English)

1 reference

26 June 2017

Alexei Brooun

1

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26 June 2017

Ketan S Gajiwala

2

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26 June 2017

Ya-Li Deng

3

1 reference

26 June 2017

Wei Liu

4

1 reference

26 June 2017

Ben Bolaños

5

1 reference

26 June 2017

Patrick Bingham

6

1 reference

26 June 2017

You-Ai He

7

1 reference

26 June 2017

Wade Diehl

8

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26 June 2017

Nicole Grable

9

1 reference

26 June 2017

Pei-Pei Kung

10

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26 June 2017

Scott Sutton

11

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26 June 2017

Karen A Maegley

12

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26 June 2017

Xiu Yu

13

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26 June 2017

Al E Stewart

14

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26 June 2017

language of work or name

English

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publication date

28 April 2016

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26 June 2017

Nature Communications

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26 June 2017

7

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26 June 2017

11384

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Creative Commons Attribution 4.0 International

26 June 2017

start time

28 April 2016

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Structural Context of Disease-Associated Mutations and Putative Mechanism of Autoinhibition Revealed by X-Ray Crystallographic Analysis of the EZH2-SET Domain

21 March 2017

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Structure of the Catalytic Domain of EZH2 Reveals Conformational Plasticity in Cofactor and Substrate Binding Sites and Explains Oncogenic Mutations

21 March 2017

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Molecular architecture of human polycomb repressive complex 2

21 March 2017

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Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2)

21 March 2017

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Role of the polycomb protein EED in the propagation of repressive histone marks

21 March 2017

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Structural basis of EZH2 recognition by EED

21 March 2017

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EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells

21 March 2017

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Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes

21 March 2017

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Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

21 March 2017

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Automated structure solution with autoSHARP

21 March 2017

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Solving structures of protein complexes by molecular replacement with Phaser

21 March 2017

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

21 March 2017

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Diverse involvement of EZH2 in cancer epigenetics

21 March 2017

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SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex

21 March 2017

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21 March 2017

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Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4853478

The Polycomb complex PRC2 and its mark in life

7 April 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4853478

EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4853478

Robust, high-throughput solution structural analyses by small angle X-ray scattering (SAXS)

7 April 2017

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The polycomb group protein EZH2 is involved in progression of prostate cancer

7 April 2017

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Kinetics of the reversible inhibition of enzyme-catalysed reactions by tight-binding inhibitors

7 April 2017

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Targeting Polycomb systems to regulate gene expression: modifications to a complex story

7 April 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4853478

Acquisition of a single EZH2 D1 domain mutation confers acquired resistance to EZH2-targeted inhibitors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4853478

Hydrogen deuterium mass spectrometry in drug discovery

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4853478

Targeting EZH2 and PRC2 dependence as novel anticancer therapy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4853478

Development of secondary mutations in wild-type and mutant EZH2 alleles cooperates to confer resistance to EZH2 inhibitors.

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4853478

Discovery and Optimization of Tetramethylpiperidinyl Benzamides as Inhibitors of EZH2

28 September 2017

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Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2.

28 September 2017

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The central role of EED in the orchestration of polycomb group complexes.

28 September 2017

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High-throughput SAXS for the characterization of biomolecules in solution: a practical approach

28 September 2017

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Elements of the polycomb repressor SU(Z)12 needed for histone H3-K27 methylation, the interface with E(Z), and in vivo function

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4853478

Accurate assessment of mass, models and resolution by small-angle scattering

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4853478

Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4853478

A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4853478

Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110α (PIK3CA).

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4853478

Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4853478

Characterizing flexible and intrinsically unstructured biological macromolecules by SAS using the Porod-Debye law.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4853478

Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4853478

A model for transmission of the H3K27me3 epigenetic mark

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4853478

The N terminus of Drosophila ESC binds directly to histone H3 and is required for E(Z)-dependent trimethylation of H3 lysine 27.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4853478

The SANT domain: a unique histone-tail-binding module?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4853478

The 5' untranslated region of Perina nuda virus (PnV) possesses a strong internal translation activity in baculovirus-infected insect cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4853478

Long residence time inhibition of EZH2 in activated polycomb repressive complex 2.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4853478

Inactivation of polycomb repressive complex 2 components in myeloproliferative and myelodysplastic/myeloproliferative neoplasms.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4853478

Composition, recruitment and regulation of the PRC2 complex

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4853478

High-throughput protein production for X-ray crystallography and use of size exclusion chromatography to validate or refute computational biological unit predictions.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4853478

28 November 2018

Identifiers

DOI

10.1038/NCOMMS11384

1 reference

Dimensions Publication ID

26 June 2017

0 references

1004435065

0 references

Fatcat ID

release_n3ursaguljeebjv2eii6cvdjfy

0 references

OpenCitations bibliographic resource ID

2024721

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference