The DNA helicase recql4 is required for normal osteoblast expansion and osteosarcoma formation (Q27311269)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25859855%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

title

The DNA helicase recql4 is required for normal osteoblast expansion and osteosarcoma formation (English)

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5 March 2020

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4

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5 March 2020

Natalie A. Sims

5

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5 March 2020

Louise E Purton

6

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5 March 2020

Carl R Walkley

9

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5 March 2020

3

Monique F Smeets

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5 March 2020

author name string

Alvin J M Ng

1

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5 March 2020

Mannu K Walia

2

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5 March 2020

Nicole C Walsh

7

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5 March 2020

T John Martin

8

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5 March 2020

language of work or name

English

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publication date

10 April 2015

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5 March 2020

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5 March 2020

volume

11

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5 March 2020

issue

4

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5 March 2020

page(s)

e1005160

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Creative Commons Attribution 4.0 International

5 March 2020

copyright license

start time

10 April 2015

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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describes a project that uses

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4393104/fullTextXML

inferred from PubMed Central ID database lookup

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Recql4 haploinsufficiency in mice leads to defects in osteoblast progenitors: Implications for low bone mass phenotype

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Defective sister-chromatid cohesion, aneuploidy and cancer predisposition in a mouse model of type II Rothmund-Thomson syndrome

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Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma

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The Rothmund-Thomson syndrome helicase RECQL4 is essential for hematopoiesis

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RECQ DNA helicases and osteosarcoma.

28 September 2017

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Senescence induced by RECQL4 dysfunction contributes to Rothmund-Thomson syndrome features in mice

28 September 2017

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Recurrent somatic structural variations contribute to tumorigenesis in pediatric osteosarcoma.

28 September 2017

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Titration of four replication factors is essential for the Xenopus laevis midblastula transition

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The helicase domain and C-terminus of human RecQL4 facilitate replication elongation on DNA templates damaged by ionizing radiation.

28 September 2017

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Endogenous bone marrow MSCs are dynamic, fate-restricted participants in bone maintenance and regeneration.

28 September 2017

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RECQL4 is essential for the transport of p53 to mitochondria in normal human cells in the absence of exogenous stress.

28 September 2017

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The N-terminal region of RECQL4 lacking the helicase domain is both essential and sufficient for the viability of vertebrate cells. Role of the N-terminal region of RECQL4 in cells

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Recurrent RECQL4 imbalance and increased gene expression levels are associated with structural chromosomal instability in sporadic osteosarcoma

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28 September 2017

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28 September 2017

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28 September 2017

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Rothmund-thomson syndrome responsible gene, RECQL4: genomic structure and products

28 September 2017

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Targeted mutation of p53 and Rb in mesenchymal cells of the limb bud produces sarcomas in mice

28 September 2017

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Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironment

31 May 2018

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G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow

31 May 2018

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Can cure in patients with osteosarcoma be achieved exclusively with chemotherapy and abrogation of surgery?

31 May 2018

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Growth retardation and skin abnormalities of the Recql4-deficient mouse.

21 January 2018

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Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors.

21 January 2018

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Decreased body weight in young Osterix-Cre transgenic mice results in delayed cortical bone expansion and accrual

21 January 2018

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EphrinB2 signaling in osteoblasts promotes bone mineralization by preventing apoptosis.

21 January 2018

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Differentiation potential of a mouse bone marrow stromal cell line.

21 January 2018

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Modeling distinct osteosarcoma subtypes in vivo using Cre:lox and lineage-restricted transgenic shRNA.

21 January 2018

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RECQL4 and p53 potentiate the activity of polymerase γ and maintain the integrity of the human mitochondrial genome

21 January 2018

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RECQL4 Regulates p53 Function In Vivo During Skeletogenesis.

21 January 2018

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Osteoblast function is compromised at sites of focal bone erosion in inflammatory arthritis

21 January 2018

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Erythropoietin couples erythropoiesis, B-lymphopoiesis, and bone homeostasis within the bone marrow microenvironment

21 January 2018

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12 December 2020

Characterization and purification of osteogenic cells from murine bone marrow by two-color cell sorting using anti-Sca-1 monoclonal antibody and wheat germ agglutinin

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[Preparation of the gene targeted knockout mice for human premature aging diseases, Werner syndrome, and Rothmund-Thomson syndrome caused by the mutation of DNA helicases]

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12 December 2020

The structural and hormonal basis of sex differences in peak appendicular bone strength in rats

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12 December 2020

Multiple malignant diseases in a patient with Rothmund-Thomson syndrome with RECQL4 mutations: Case report and literature review

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12 December 2020

10.1371/JOURNAL.PGEN.1005160

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25859855%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25859855%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25859855%20AND%20SRC:MED&resulttype=core&format=json