Potentiation of neurotoxicity in double-mutant mice with Pink1 ablation and A53T-SNCA overexpression (Q27301199)

26 June 2017

title

Potentiation of neurotoxicity in double-mutant mice with Pink1 ablation and A53T-SNCA overexpression (English)

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26 June 2017

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Jochen Roeper

8

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author name string

Suzana Gispert

1

1 reference

26 June 2017

Nadine Brehm

2

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26 June 2017

Jonas Weil

3

1 reference

26 June 2017

Kay Seidel

4

1 reference

26 June 2017

Udo Rüb

5

1 reference

26 June 2017

Beatrice Kern

6

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26 June 2017

Michael Walter

7

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26 June 2017

Georg Auburger

9

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26 June 2017

language of work or name

English

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publication date

8 October 2014

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26 June 2017

published in

Human Molecular Genetics

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26 June 2017

volume

24

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26 June 2017

issue

4

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26 June 2017

page(s)

1061-1076

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describes a project that uses

26 June 2017

limma

1 reference

22 June 2022

https://europepmc.org/article/PMC/4986551

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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Parkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathy

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PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

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28 September 2017

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28 September 2017

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28 September 2017

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rAAV2/7 vector-mediated overexpression of alpha-synuclein in mouse substantia nigra induces protein aggregation and progressive dose-dependent neurodegeneration

28 September 2017

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Parkin depletion delays motor decline dose-dependently without overtly affecting neuropathology in α-synuclein transgenic mice

28 September 2017

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28 September 2017

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Loss of PINK1 increases the heart's vulnerability to ischemia-reperfusion injury.

28 September 2017

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ATXN2-CAG42 sequesters PABPC1 into insolubility and induces FBXW8 in cerebellum of old ataxic knock-in mice.

28 September 2017

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28 September 2017

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Striatal dopamine transmission is subtly modified in human A53Tα-synuclein overexpressing mice

28 September 2017

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28 September 2017

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Restriction of trophic factors and nutrients induces PARKIN expression

28 September 2017

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28 September 2017

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A53T-alpha-synuclein-overexpression in the mouse nigrostriatal pathway leads to early increase of 14-3-3 epsilon and late increase of GFAP

28 September 2017

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Parkin promotes the ubiquitination and degradation of the mitochondrial fusion factor mitofusin 1.

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986551

Mutations in PINK1 and Parkin impair ubiquitination of Mitofusins in human fibroblasts

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986551

Bioenergetics of neurons inhibit the translocation response of Parkin following rapid mitochondrial depolarization.

28 September 2017

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28 September 2017

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28 September 2017

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Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1.

28 September 2017

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Alpha-synuclein deficiency leads to increased glyoxalase I expression and glycation stress

28 September 2017

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Role of post-translational modifications in modulating the structure, function and toxicity of alpha-synuclein: implications for Parkinson's disease pathogenesis and therapies

28 September 2017

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DJ-1 deficient mice demonstrate similar vulnerability to pathogenic Ala53Thr human alpha-syn toxicity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986551

The Parkinson-associated protein PINK1 interacts with Beclin1 and promotes autophagy

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986551

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28 September 2017

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Specificity and regulation of casein kinase-mediated phosphorylation of alpha-synuclein

28 September 2017

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28 September 2017

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Alpha-synuclein overexpression in oligodendrocytic cells results in impaired adhesion to fibronectin and cell death

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4986551

Aggregation and neurotoxicity of alpha-synuclein and related peptides

28 September 2017

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28 September 2017

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28 September 2017

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31 May 2018

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Pink1 suppresses alpha-synuclein-induced phenotypes in a Drosophila model of Parkinson's disease.

31 May 2018

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Expression of Pink1 with α-synuclein in the dopaminergic neurons of Drosophila leads to increases in both lifespan and healthspan.

21 January 2018

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Mutant alpha-synuclein-induced degeneration is reduced by parkin in a fly model of Parkinson's disease.

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PINK1 and Parkin complementarily protect dopaminergic neurons in vertebrates

21 January 2018

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Transgenic mice expressing mutant A53T human alpha-synuclein show neuronal dysfunction in the absence of aggregate formation.

21 January 2018

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Spinal cord lesions in sporadic Parkinson's disease

21 January 2018

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21 January 2018

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Alpha-synuclein deficiency affects brain Foxp1 expression and ultrasonic vocalization.

21 January 2018

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The BRICHOS domain, amyloid fibril formation, and their relationship

21 January 2018

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BRI2-BRICHOS is increased in human amyloid plaques in early stages of Alzheimer's disease

21 January 2018

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PINK1-linked parkinsonism is associated with Lewy body pathology

21 January 2018

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21 January 2018

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Complexin-1 and Foxp1 Expression Changes Are Novel Brain Effects of Alpha-Synuclein Pathology

21 January 2018

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Mono- and double-mutant mouse models of Parkinson's disease display severe mitochondrial damage

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25296918

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/HMG/DDU520

1 reference

release_gz7v62nq7zh5tkivtyv6sydpni

26 June 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/gz7v62nq7zh5tkivtyv6sydpni

mapped directly with Wikidata item

24 November 2022

based on heuristic

PMC publication ID

4986551

0 references

1 reference