capmatinib (Q27075685)

1029712-80-8 (English)

3 October 2016

canonical SMILES

CNC(=O)C1=C(C=C(C=C1)C2=NN3C(=CN=C3N=C2)CC4=CC5=C(C=C4)N=CC=C5)F

1 reference

1029712-80-8 (English)

World Health Organisation international non-proprietary name

3 October 2016

active ingredient in

Tabrecta

0 references

capmatinib (English)

1 reference

published in

Recommended INN: List 73

publication date

2015

medical condition treated

non-small-cell lung carcinoma

approved by

United States Food and Drug Administration

start time

6 May 2020

1 reference

reference URL

https://www.fda.gov/news-events/press-announcements/fda-approves-first-targeted-therapy-treat-aggressive-form-lung-cancer

physically interacts with

MET proto-oncogene, receptor tyrosine kinase

subject has role

reaction inhibitor

1 reference

Open Targets Platform

https://platform.opentargets.org/drug/CHEMBL3188267

14 August 2023

reference URL

mass

412.144787±0 dalton

1 reference

1029712-80-8 (English)

protein kinase inhibitors

3 October 2016

subject has role

0 references

Commons category

Capmatinib

0 references

Identifiers

InChI

InChI=1S/C23H17FN6O/c1-25-22(31)18-6-5-16(11-19(18)24)21-13-28-23-27-12-17(30(23)29-21)10-14-4-7-20-15(9-14)3-2-8-26-20/h2-9,11-13H,10H2,1H3,(H,25,31)

1 reference

1029712-80-8 (English)

3 October 2016

1 reference

Global Substance Registration System

1029712-80-8 (English)

3 October 2016

2 references

UNII

TY34L4F9OZ

CAPMATINIB (English)

3 October 2016

https://commonchemistry.cas.org/detail?cas_rn=1029712-80-8

10 April 2021

1 reference

capmatinib (English)

3 October 2016

2 references

1029712-80-8 (English)

3 October 2016

ChEBI ID

231693

mapping relation type

exact match

1 reference

International Chemical Identifier

InChI

InChI=1S/C23H17FN6O/c1-25-22(31)18-6-5-16(11-19(18)24)21-13-28-23-27-12-17(30(23)29-21)10-14-4-7-20-15(9-14)3-2-8-26-20/h2-9,11-13H,10H2,1H3,(H,25,31)

1 reference

CAPMATINIB (English)

3 October 2016

2 references

inferred from InChIKey

Mapping file of InChIStrings, InChIKeys and DTXSIDs for the EPA CompTox Dashboard

1 reference

2 references

DSSTOX compound identifier

0 references

1 reference

ECHA Substance Infocard database

ECHA Substance Infocard ID

100.246.414

29 July 2019

ECHA Substance Infocard ID

2-Fluoro-N-methyl-4-[7-[(quinolin-6-yl)methyl]imidazo[1,2-b]-[1,2,4]triazin-2-yl]benzamide (English)

quotation

CAS no.: 1029712-80-8 (English)

100.246.414

1 reference

ECHA Substance Infocard database

ECHA Substance Infocard ID

100.246.414

29 July 2019

World Health Organisation international non-proprietary name numeric ID

2-Fluoro-N-methyl-4-[7-[(quinolin-6-yl)methyl]imidazo[1,2-b]-[1,2,4]triazin-2-yl]benzamide (English)

quotation

CAS no.: 1029712-80-8 (English)

9948

1 reference

reference URL

https://mednet-communities.net/inn/db/ViewINN.aspx?i=9948

Guide to Pharmacology Ligand ID

7904

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

7904

capmatinib (English)

3 October 2016

capmatinib

0 references

DrugBank ID

DB11791

1 reference

Human Metabolome Database ID

HMDB0249595

2 references

based on heuristic

inferred from InChIKey

UNII

TY34L4F9OZ

2 references

Global Substance Registration System

UNII

TY34L4F9OZ

CAPMATINIB (English)

3 October 2016