An overview on the role of FLT3-tyrosine kinase receptor in acute myeloid leukemia: biology and treatment (Q27027207)

Michela Palmisano

series ordinal

2

1 reference

Chiara Nicci

series ordinal

3

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Sergio Storti

series ordinal

4

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language of work or name

1 reference

5 March 2012

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6

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page(s)

e8

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issue

1

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Creative Commons Attribution-NonCommercial 4.0 International

copyright license

start time

17 April 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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FLT-3: a new focus in the understanding of acute leukemia

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28 September 2017

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Results from a randomized trial of salvage chemotherapy followed by lestaurtinib for patients with FLT3 mutant AML in first relapse

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28 September 2017

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28 September 2017

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Deregulation of signaling pathways in acute myeloid leukemia

28 September 2017

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Identification of a novel type of ITD mutations located in nonjuxtamembrane domains of the FLT3 tyrosine kinase receptor

28 September 2017

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Monitoring of FLT3 phosphorylation status and its response to drugs by flow cytometry in AML blast cells

28 September 2017

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Sorafenib induces apoptosis of AML cells via Bim-mediated activation of the intrinsic apoptotic pathway.

28 September 2017

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Constitutively activated FLT3 phosphorylates BAD partially through pim-1.

28 September 2017

1 reference

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A phase 2 trial of the FLT3 inhibitor lestaurtinib (CEP701) as first-line treatment for older patients with acute myeloid leukemia not considered fit for intensive chemotherapy

28 September 2017

1 reference

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Point mutations in the juxtamembrane domain of FLT3 define a new class of activating mutations in AML.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419636

AML-associated Flt3 kinase domain mutations show signal transduction differences compared with Flt3 ITD mutations.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419636

Flt3 tandem duplication mutations cooperate with Wnt signaling in leukemic signal transduction.

28 September 2017

1 reference

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Novel protein kinases and molecular mechanisms of autoinhibition

28 September 2017

1 reference

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FLT3/ITD mutation signaling includes suppression of SHP-1.

28 September 2017

1 reference

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The molecular basis of leukemia

28 September 2017

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Pim-1 is up-regulated by constitutively activated FLT3 and plays a role in FLT3-mediated cell survival

28 September 2017

1 reference

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Possibilities for tailored and targeted therapy in paediatric acute myeloid leukaemia

28 September 2017

1 reference

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FLT3 ligand regulates apoptosis through AKT-dependent inactivation of transcription factor FoxO3.

28 September 2017

1 reference

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FLT3 inhibitors: a paradigm for the development of targeted therapeutics for paediatric cancer

28 September 2017

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Flt3 mutation activates p21WAF1/CIP1 gene expression through the action of STAT5.

28 September 2017

1 reference

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Flt3 Ligand: Role in Control of Hematopoietic and Immune Functions of the Bone Marrow

28 September 2017

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Mutations in the tyrosine kinase domain of FLT3 define a new molecular mechanism of acquired drug resistance to PTK inhibitors in FLT3-ITD–transformed hematopoietic cells

28 September 2017

1 reference

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Internal tandem duplication mutation of FLT3 blocks myeloid differentiation through suppression of C/EBPα expression

28 September 2017

1 reference

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FLT3: ITDoes matter in leukemia

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419636

FLT3 ligand causes autocrine signaling in acute myeloid leukemia cells

28 September 2017

1 reference

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Flt3 mutations and leukaemia

28 September 2017

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Molecular genetics of human leukemias: new insights into therapy

28 September 2017

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The roles of FLT3 in hematopoiesis and leukemia

28 September 2017

1 reference

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Finding the next Gleevec: FLT3 targeted kinase inhibitor therapy for acute myeloid leukemia

28 September 2017

1 reference

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Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease

28 September 2017

1 reference

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Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419636

The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the Unite

28 September 2017

1 reference

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Blocking oncogenic Ras signaling for cancer therapy

28 September 2017

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28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419636

Phase I and pharmacokinetic study of PKC412, an inhibitor of protein kinase C.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419636

Flt3 ligand induces tyrosine phosphorylation of gab1 and gab2 and their association with shp-2, grb2, and PI3 kinase

28 September 2017

1 reference

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Constitutive activation of FLT3 in acute myeloid leukaemia and its consequences for growth of 32D cells

28 September 2017

1 reference

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The process of leukemogenesis

28 September 2017

1 reference

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Biology of flt3 ligand and receptor

28 September 2017

1 reference

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c-kit ligand and Flt3 ligand: stem/progenitor cell factors with overlapping yet distinct activities

28 September 2017

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Expression of the FLT3 gene in human leukemia-lymphoma cell lines

31 May 2018

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A novel point mutation within the juxtamembrane domain of the flt3 gene in acute myeloid leukemia.

31 May 2018

1 reference

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KIT and FLT3 receptor tyrosine kinase mutations in acute myeloid leukemia with favorable cytogenetics: two novel mutations and selective occurrence in leukemia subtypes and age groups

28 November 2018

1 reference

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Human Flt3 is expressed at the hematopoietic stem cell and the granulocyte/macrophage progenitor stages to maintain cell survival

28 November 2018

1 reference

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Specific detection of Flt3 point mutations by highly sensitive real-time polymerase chain reaction in acute myeloid leukemia

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419636

Internal tandem duplication of fms-like tyrosine kinase 3 is associated with poor outcome in patients with myelodysplastic syndrome.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419636

Enforced expression of an Flt3 internal tandem duplication in human CD34+ cells confers properties of self-renewal and enhanced erythropoiesis

28 November 2018

1 reference

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Identifying and characterizing a novel activating mutation of the FLT3 tyrosine kinase in AML.

28 November 2018

1 reference

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FLT-3 aberrations in acute promyelocytic leukaemia: clinicopathological associations and prognostic impact.

28 November 2018

1 reference

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FLT3 receptors with internal tandem duplications promote cell viability and proliferation by signaling through Foxo proteins

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419636

FLT3 mutations are associated with other molecular lesions in AML.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419636

Novel FLT3 point mutation in acute myeloid leukaemia

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419636

Rapid detection of Flt3 mutations in acute myeloid leukemia patients by denaturing HPLC.

28 November 2018

1 reference

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Overexpression and constitutive activation of FLT3 induces STAT5 activation in primary acute myeloid leukemia blast cells

28 November 2018

1 reference

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Survival of acute myeloid leukemia cells requires PI3 kinase activation

28 November 2018

1 reference

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Flt3-mediated signaling in human acute myelogenous leukemia (AML) blasts: a functional characterization of Flt3-ligand effects in AML cell populations with and without genetic Flt3 abnormalities.

28 November 2018

1 reference

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Identification of novel FLT-3 Asp835 mutations in adult acute myeloid leukaemia

28 November 2018

1 reference

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Point mutations in the FLT3 gene in AML.

28 November 2018

1 reference

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Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways.

28 November 2018

1 reference

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Localization of the human stem cell tyrosine kinase-1 gene (FLT3) to 13q12→q13

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419636

Flt3-ligand production by human bone marrow stromal cells

28 November 2018

1 reference

12 December 2020

In vitro expansion of hematopoietic progenitors and maintenance of stem cells: comparison between FLT3/FLK-2 ligand and KIT ligand

1 reference

12 December 2020

Internal tandem duplication of the flt3 gene found in acute myeloid leukemia

1 reference

12 December 2020

Expression of FLT3 receptor and FLT3-ligand in human leukemia-lymphoma cell lines

1 reference

12 December 2020

FLT3 inhibition as tailored therapy for acute myeloid leukemia

1 reference

12 December 2020

Human FLT3/FLK2 receptor tyrosine kinase is expressed at the surface of normal and malignant hematopoietic cells

1 reference

12 December 2020

Isolation and chromosomal localization of a novel FMS-like tyrosine kinase gene

1 reference

12 December 2020

Flt3high and Flt3low CD34+ progenitor cells isolated from human bone marrow are functionally distinct

1 reference

12 December 2020

Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines

1 reference

12 December 2020

Genomic structure of human FLT3: implications for mutational analysis

1 reference

12 December 2020

Genomic structure of the downstream part of the human FLT3 gene: exon/intron structure conservation among genes encoding receptor tyrosine kinases (RTK) of subclass III

1 reference

12 December 2020

Evolution of FLT3-ITD and D835 activating point mutations in relapsing acute myeloid leukemia and response to salvage therapy

1 reference

12 December 2020