C. elegans in high-throughput drug discovery (Q27027125)

1

1 reference

Cliff J. Luke

2

1 reference

David H. Perlmutter

3

1 reference

Gary A. Silverman

4

1 reference

Stephen C. Pak

5

1 reference

language of work or name

1 reference

April 2014

1 reference

Advanced Drug Delivery Reviews

published in

1 reference

volume

69-70

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page(s)

247-53

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Automated high-content live animal drug screening using C. elegans expressing the aggregation prone serpin α1-antitrypsin Z

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Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics

21 March 2017

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The genetics of Caenorhabditis elegans

21 March 2017

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The Parallel Worm Tracker: a platform for measuring average speed and drug-induced paralysis in nematodes

7 April 2017

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Genome sequence of the nematode C. elegans: a platform for investigating biology

21 March 2017

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Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

21 March 2017

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A C. elegans mutant that lives twice as long as wild type

21 March 2017

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Droplet-Based Microfluidic Platforms for the Encapsulation and Screening of Mammalian Cells and Multicellular Organisms

21 March 2017

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The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

21 March 2017

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A central role of the BK potassium channel in behavioral responses to ethanol in C. elegans

21 March 2017

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Antifungal chemical compounds identified using a C. elegans pathogenicity assay

21 March 2017

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An ultra high-throughput, whole-animal screen for small molecule modulators of a specific genetic pathway in Caenorhabditis elegans

21 March 2017

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A genome-wide RNAi screen in Caenorhabditis elegans identifies the nicotinic acetylcholine receptor subunit ACR-7 as an antipsychotic drug target

21 March 2017

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Drug absorption efficiency in Caenorhbditis elegans delivered by different methods

21 March 2017

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A novel high throughput assay for anthelmintic drug screening and resistance diagnosis by real-time monitoring of parasite motility

21 March 2017

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Lethal paralysis of Caenorhabditis elegans by Pseudomonas aeruginosa

21 March 2017

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daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans

21 March 2017

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Suppressors of a lin-12 hypomorph define genes that interact with both lin-12 and glp-1 in Caenorhabditis elegans

21 March 2017

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Genes that regulate both development and longevity in Caenorhabditis elegans

21 March 2017

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The Caenorhabditis elegans Lifespan Machine

21 March 2017

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Disorders of protein misfolding: alpha-1-antitrypsin deficiency as prototype

28 September 2017

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WormSizer: high-throughput analysis of nematode size and shape

28 September 2017

1 reference

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Utility of an improved model of amyloid-beta (Aβ₁₋₄₂) toxicity in Caenorhabditis elegans for drug screening for Alzheimer's disease

28 September 2017

1 reference

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Osteogenesis Imperfecta: A Review with Clinical Examples.

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019719

An image analysis toolbox for high-throughput C. elegans assays

28 September 2017

1 reference

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WormScan: a technique for high-throughput phenotypic analysis of Caenorhabditis elegans

28 September 2017

1 reference

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An efficient and novel screening model for assessing the bioactivity of extracts against multidrug-resistant Pseudomonas aeruginosa using Caenorhabditis elegans

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019719

High-throughput behavioral analysis in C. elegans

28 September 2017

1 reference

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Real-time multimodal optical control of neurons and muscles in freely behaving Caenorhabditis elegans

28 September 2017

1 reference

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A predictive model for drug bioaccumulation and bioactivity in Caenorhabditis elegans

28 September 2017

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High-throughput screening and small animal models, where are we?

28 September 2017

1 reference

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Microfluidics for the analysis of behavior, nerve regeneration, and neural cell biology in C. elegans

28 September 2017

1 reference

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Fast, automated measurement of nematode swimming (thrashing) without morphometry

28 September 2017

1 reference

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SU-8 force sensing pillar arrays for biological measurements

28 September 2017

1 reference

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Enhanced Caenorhabditis elegans locomotion in a structured microfluidic environment

28 September 2017

1 reference

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Olfactory behavior of swimming C. elegans analyzed by measuring motile responses to temporal variations of odorants

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019719

Artificial dirt: microfluidic substrates for nematode neurobiology and behavior

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019719

An antidepressant that extends lifespan in adult Caenorhabditis elegans

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019719

Analysis of nematode mechanics by piezoresistive displacement clamp

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019719

Nemo: a computational tool for analyzing nematode locomotion

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019719

Invertebrate animal models of diseases as screening tools in drug discovery

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019719

Drug discovery: here comes the worm

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019719

Caenorhabditis elegans: a versatile platform for drug discovery

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019719

C. elegans models of age-associated neurodegenerative diseases: lessons from transgenic worm models of Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019719

Caenorhabditis elegans MPP+ model of Parkinson's disease for high-throughput drug screenings

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019719

The role of autophagy in alpha-1-antitrypsin deficiency: a specific cellular response in genetic diseases associated with aggregation-prone proteins

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019719

Pharmacology of delayed aging and extended lifespan of Caenorhabditis elegans

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019719

Identification of novel antimicrobials using a live-animal infection model

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019719

Anticonvulsant medications extend worm life-span

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019719

WormBase: a multi-species resource for nematode biology and genomics

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019719

The use of functional genomics in C. elegans for studying human development and disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019719

Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019719

Genetic pharmacology: interactions between drugs and gene products in Caenorhabditis elegans

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019719

Signalling pathways initiated by receptor protein tyrosine kinases in Drosophila

28 September 2017

1 reference

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The ins and outs of programmed cell death during C. elegans development

28 September 2017

1 reference

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Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans

28 September 2017

1 reference

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Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019719

Molecular analysis of mutations in the Caenorhabditis elegans collagen gene dpy-7

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019719

Automated sorting of live C. elegans using laFACS.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019719

Genetic suppression of phenotypes arising from mutations in dystrophin-related genes in Caenorhabditis elegans.

31 May 2018

1 reference

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Presenilin is required for proper morphology and function of neurons in C. elegans

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019719

DevStaR: high-throughput quantification of C. elegans developmental stages

31 May 2018

1 reference

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A liquid phase based C. elegans behavioral analysis system identifies motor activity loss in a nematode Parkinson's disease model.

28 November 2018

1 reference

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Droplet microfluidics for characterizing the neurotoxin-induced responses in individual Caenorhabditis elegans

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019719

A high-throughput screen for chemicals that increase the lifespan of Caenorhabditis elegans

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019719

RNAi screens in Caenorhabditis elegans in a 96-well liquid format and their application to the systematic identification of genetic interactions

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019719

Finding function in novel targets: C. elegans as a model organism.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019719

OrthoDisease: a database of human disease orthologs

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019719

Prednisone reduces muscle degeneration in dystrophin-deficient Caenorhabditis elegans

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019719

The stn-1 syntrophin gene of C.elegans is functionally related to dystrophin and dystrobrevin.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019719

Genetics of RAS signaling in C. elegans.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019719

Analysis of Protein Domain Families inCaenorhabditis elegans

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019719

Programmed cell death in Caenorhabditis elegans

28 November 2018

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12 December 2020

Modeling polyglutamine pathogenesis in C. elegans

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12 December 2020

Increased lifespan in transgenic Caenorhabditis elegans overexpressing human alpha-synuclein

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12 December 2020

A small-molecule screen in C. elegans yields a new calcium channel antagonist

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12 December 2020

A systematic RNAi screen reveals involvement of endocytic pathway in neuronal dysfunction in α-synuclein transgenic C . elegans

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12 December 2020

10.1016/J.ADDR.2013.12.001

Identifiers

DOI

0 references

1 reference

PubMed publication ID

24333896

1 reference