AMPA receptors as a molecular target in epilepsy therapy (Q27026055)

language of work or name

1 reference

2013

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Acta neurologica Scandinavica. Supplementum

published in

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page(s)

9-18

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issue

197

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Preclinical pharmacology of perampanel, a selective non-competitive AMPA receptor antagonist

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Adjunctive perampanel for refractory partial-onset seizures: randomized phase III study 304

21 March 2017

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Limbic Network Synchronization and Temporal Lobe Epilepsy

21 March 2017

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ZK200775: a phosphonate quinoxalinedione AMPA antagonist for neuroprotection in stroke and trauma

21 March 2017

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6-Amino quinazolinedione sulfonamides as orally active competitive AMPA receptor antagonists

21 March 2017

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Quinazolinedione sulfonamides: a novel class of competitive AMPA receptor antagonists with oral activity

21 March 2017

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TARP auxiliary subunits switch AMPA receptor antagonists into partial agonists

21 March 2017

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Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core

21 March 2017

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Synaptic plasticity: multiple forms, functions, and mechanisms

21 March 2017

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Progress report on new antiepileptic drugs: a summary of the Eigth Eilat Conference (EILAT VIII)

21 March 2017

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The neurobiology of antiepileptic drugs

21 March 2017

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Memory, plasticity and sleep - A role for calcium permeable AMPA receptors?

21 March 2017

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Mechanism of inhibition of GluA2 AMPA receptor channel opening by 2,3-benzodiazepine derivatives: functional consequences of replacing a 7,8-methylenedioxy with a 7,8-ethylenedioxy moiety

28 September 2017

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Regulation of AMPA receptor trafficking and synaptic plasticity.

28 September 2017

1 reference

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Mechanism of Inhibition of the GluA2 AMPA Receptor Channel Opening: the Role of 4-Methyl versus 4-Carbonyl Group on the Diazepine Ring of 2,3-Benzodiazepine Derivatives.

28 September 2017

1 reference

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The expanding social network of ionotropic glutamate receptors: TARPs and other transmembrane auxiliary subunits

28 September 2017

1 reference

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TARPs differentially decorate AMPA receptors to specify neuropharmacology

28 September 2017

1 reference

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AMPA receptors and synaptic plasticity: a chemist's perspective

28 September 2017

1 reference

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Subunit composition of synaptic AMPA receptors revealed by a single-cell genetic approach

28 September 2017

1 reference

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Ca(2+) permeable AMPA receptor induced long-term potentiation requires PI3/MAP kinases but not Ca/CaM-dependent kinase II.

28 September 2017

1 reference

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The role of the GluR2 subunit in AMPA receptor function and synaptic plasticity.

28 September 2017

1 reference

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Ca2+-permeable AMPA receptors in synaptic plasticity and neuronal death

28 September 2017

1 reference

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Regulatory mechanisms of AMPA receptors in synaptic plasticity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506648

Competitive AMPA receptor antagonists

28 September 2017

1 reference

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Molecular analysis of the interaction of the pyrazine derivatives RPR119990 and RPR117824 with human AMPA-type glutamate receptor channels

28 September 2017

1 reference

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Molecular mechanism of AMPA receptor noncompetitive antagonism

28 September 2017

1 reference

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Evidence for low GluR2 AMPA receptor subunit expression at synapses in the rat basolateral amygdala.

28 September 2017

1 reference

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Ionotropic and metabotropic glutamate receptor structure and pharmacology

28 September 2017

1 reference

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YM872: a selective, potent and highly water-soluble alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor antagonist.

28 September 2017

1 reference

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Non-competitive AMPA antagonists of 2,3-benzodiazepine type

28 September 2017

1 reference

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Atropisomeric quinazolin-4-one derivatives are potent noncompetitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists

28 September 2017

1 reference

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In vitro and in vivo antagonism of AMPA receptor activation by (3S, 4aR, 6R, 8aR)-6-[2-(1(2)H-tetrazole-5-yl) ethyl] decahydroisoquinoline-3-carboxylic acid.

28 September 2017

1 reference

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(3SR,4aRS,6RS,8aRS)-6-[2-(1H-tetrazol-5-yl)ethyl]decahydroisoquinoline-3 - carboxylic acid: a structurally novel, systemically active, competitive AMPA receptor antagonist.

28 September 2017

1 reference

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Excitatory amino acid receptors in the vertebrate central nervous system

28 September 2017

1 reference

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Excitatory amino acid antagonists and memory: effect of drugs acting at N-methyl-D-aspartate receptors in learning and memory tasks

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506648

Removal of AMPA receptors (AMPARs) from synapses is preceded by transient endocytosis of extrasynaptic AMPARs

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506648

GYKI 52466, a 2,3-benzodiazepine, is a highly selective, noncompetitive antagonist of AMPA/kainate receptor responses.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506648

Single neurones can initiate synchronized population discharge in the hippocampus

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506648

Inhibitory control of local excitatory circuits in the guinea-pig hippocampus

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506648

Excitatory synaptic interactions between CA3 neurones in the guinea-pig hippocampus

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506648

Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506648

New quinoxalinediones show potent antagonism of quisqualate responses in cultured mouse cortical neurons.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506648

2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: a neuroprotectant for cerebral ischemia.

31 May 2018

1 reference

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The involvement of excitatory amino acids in neocortical epileptogenesis: NMDA and non-NMDA receptors

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506648

Bicuculline-induced epileptogenesis in the human neocortex maintained in vitro

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506648

Low-calcium field burst discharges of CA1 pyramidal neurones in rat hippocampal slices.

31 May 2018

1 reference

Cellular mechanism of neuronal synchronization in epilepsy.

21 January 2018

1 reference

Synaptic and intrinsic conductances shape picrotoxin-induced synchronized after-discharges in the guinea-pig hippocampal slice

21 January 2018

1 reference

AMPA receptor antagonists, GYKI 52466 and NBQX, do not block the induction of long-term potentiation at therapeutically relevant concentrations.

21 January 2018

1 reference

NBQX does not affect learning and memory tasks in mice: a comparison with D-CPPene and ifenprodil.

21 January 2018

1 reference

The non-NMDA receptor antagonist NBQX does not affect rats performance in the object recognition task.

21 January 2018

1 reference

Stargazin modulates AMPA receptor antagonism

21 January 2018

1 reference

Expression of transcripts encoding AMPA receptor subunits and associated postsynaptic proteins in the macaque brain

21 January 2018

1 reference

A venus flytrap mechanism for activation and desensitization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors.

21 January 2018

1 reference

Antiepileptogenic and anticonvulsant effects of NBQX, a selective AMPA receptor antagonist, in the rat kindling model of epilepsy.

21 January 2018

1 reference

Effect of YM872, a selective and highly water-soluble AMPA receptor antagonist, in the rat kindling and rekindling model of epilepsy

21 January 2018

1 reference

Effects of YM90K, a selective AMPA receptor antagonist, on amygdala-kindling and long-term hippocampal potentiation in the rat.

21 January 2018

1 reference

alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) antagonists: from bench to bedside

21 January 2018

1 reference

9-Carboxymethyl-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one-2-carbocylic acid (RPR117824): selective anticonvulsive and neuroprotective AMPA antagonist.

21 January 2018

1 reference

Effect of novel AMPA antagonist, NS1209, on status epilepticus. An experimental study in rat.

21 January 2018

1 reference

The effect of the non-NMDA receptor antagonist GYKI 52466 and NBQX and the competitive NMDA receptor antagonist D-CPPene on the development of amygdala kindling and on amygdala-kindled seizures.

21 January 2018

1 reference

Functional characterization of YM928, a novel moncompetitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist

21 January 2018

1 reference

Effect of YM928, a novel AMPA receptor antagonist, on seizures in EL mice and kainate-induced seizures in rats

21 January 2018

1 reference

Evaluation of adjunctive perampanel in patients with refractory partial-onset seizures: Results of randomized global phase III study 305

21 January 2018

1 reference

Randomized phase III study 306: adjunctive perampanel for refractory partial-onset seizures.

21 January 2018

1 reference

Characterization of the binding site for a novel class of noncompetitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonists.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506648

SPD 502: a water-soluble and in vivo long-lasting AMPA antagonist with neuroprotective activity.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506648

Electrophysiological substrates for focal epilepsies.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506648

The non-N-methyl-D-aspartate receptor antagonists, GYKI 52466 and NBQX are anticonvulsant in two animal models of reflex epilepsy

28 November 2018

1 reference

12 December 2020

Involvement of non-NMDA receptors in picrotoxin-induced epileptiform activity in the hippocampus

1 reference

12 December 2020

The anticonvulsant effect of the non-NMDA antagonists, NBQX and GYKI 52466, in mice

1 reference

12 December 2020

Anticonvulsant activity of AMPA/kainate antagonists: comparison of GYKI 52466 and NBOX in maximal electroshock and chemoconvulsant seizure models

1 reference

12 December 2020

The kainate/quisqualate receptor antagonist, CNQX, blocks the fast component of spontaneous epileptiform activity in organotypic cultures of rat hippocampus

1 reference

12 December 2020

New non competitive AMPA antagonists

1 reference

12 December 2020

YM90K: pharmacological characterization as a selective and potent alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate receptor antagonist

1 reference

12 December 2020

How do seizures begin? Clues from hippocampal slices

1 reference

12 December 2020

Probenecid pretreatment enhances anticonvulsant action of NBQX in mice

1 reference

12 December 2020

Antagonism of spontaneous and evoked bursts by 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) in the CA3 region of the in vitro hippocampus

1 reference

12 December 2020

Synchronous discharges in the rat entorhinal cortex in vitro: site of initiation and the role of excitatory amino acid receptors

1 reference

12 December 2020