Scrutinizing ciliopathies by unraveling ciliary interaction networks (Q27025614)

H. H. Arts

series ordinal

2

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R. Roepman

series ordinal

3

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language of work or name

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15 October 2011

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published in

Human Molecular Genetics

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volume

20

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issue

R2

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page(s)

R149-57

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Landmarks in cilia research from Leeuwenhoek to us.

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Mechanisms of nephronophthisis and related ciliopathies

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Molecular genetics and pathogenic mechanisms for the severe ciliopathies: insights into neurodevelopment and pathogenesis of neural tube defects

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The ciliopathies in neuronal development: a clinical approach to investigation of Joubert syndrome and Joubert syndrome-related disorders

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Retinal dystrophy in Bardet-Biedl syndrome and related syndromic ciliopathies

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Centrosomes and cilia in human disease.

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Strange as it may seem: the many links between Wnt signaling, planar cell polarity, and cilia

21 January 2018

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Neuronal ciliary signaling in homeostasis and disease

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Cilia in the CNS: the quiet organelle claims center stage

21 January 2018

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Tail wags dog: primary cilia and tumorigenesis

21 January 2018

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Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesis

21 January 2018

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Pancreatic cancer and precursor pancreatic intraepithelial neoplasia lesions are devoid of primary cilia

21 January 2018

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Constructing and deconstructing roles for the primary cilium in tissue architecture and cancer

21 January 2018

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Sonic hedgehog paracrine signaling regulates metastasis and lymphangiogenesis in pancreatic cancer

21 January 2018

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Role of primary cilia in brain development and cancer

21 January 2018

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Hedgehog signaling and gastrointestinal cancer

21 January 2018

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Primary cilia are decreased in breast cancer: analysis of a collection of human breast cancer cell lines and tissues

21 January 2018

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Transcriptional regulators in kidney disease: gatekeepers of renal homeostasis.

21 January 2018

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Impaired Wnt-beta-catenin signaling disrupts adult renal homeostasis and leads to cystic kidney ciliopathy

21 January 2018

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Role of epidermal primary cilia in the homeostasis of skin and hair follicles

21 January 2018

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Expression of primary cilia in mammalian cells

21 January 2018

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The primary cilium as a cellular signaling center: lessons from disease

21 January 2018

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Hedgehog signalling in the mouse requires intraflagellar transport proteins

21 January 2018

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Patched1 regulates hedgehog signaling at the primary cilium

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

An Ift80 mouse model of short rib polydactyly syndromes shows defects in hedgehog signalling without loss or malformation of cilia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

Mutations in KIF7 link Joubert syndrome with Sonic Hedgehog signaling and microtubule dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

The emerging complexity of the vertebrate cilium: new functional roles for an ancient organelle

21 January 2018

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Regulation of primary cilia formation and left-right patterning in zebrafish by a noncanonical Wnt signaling mediator, duboraya

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

The primary cilium as the cell's antenna: signaling at a sensory organelle

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

Bardet-Biedl syndrome-associated small GTPase ARL6 (BBS3) functions at or near the ciliary gate and modulates Wnt signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

The canonical Wnt signaling pathway is not involved in renal cyst development in the kidneys of inv mutant mice.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

Subcellular spatial regulation of canonical Wnt signalling at the primary cilium

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

Planar cell polarity, ciliogenesis and neural tube defects

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

Dishevelled controls apical docking and planar polarization of basal bodies in ciliated epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

The planar cell polarity effector Fuz is essential for targeted membrane trafficking, ciliogenesis and mouse embryonic development

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

Planar cell polarity acts through septins to control collective cell movement and ciliogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

PCP effector gene Inturned is an important regulator of cilia formation and embryonic development in mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

Planar cell polarity signaling, cilia and polarized ciliary beating

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

Insulin/FGF-binding ciliary membrane glycoprotein from Tetrahymena

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

FGF-induced vesicular release of Sonic hedgehog and retinoic acid in leftward nodal flow is critical for left-right determination.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

FGF-dependent left-right asymmetry patterning in zebrafish is mediated by Ier2 and Fibp1

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

FGF signalling during embryo development regulates cilia length in diverse epithelia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

Notch signaling regulates left-right asymmetry determination by inducing Nodal expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

Notch signaling controls the balance of ciliated and secretory cell fates in developing airways

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

Notch signalling regulates left-right asymmetry through ciliary length control

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

A role for the primary cilium in Notch signaling and epidermal differentiation during skin development

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

Primary cilia regulate mTORC1 activity and cell size through Lkb1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

Loss of primary cilia upregulates renal hypertrophic signaling and promotes cystogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

PDGFRalphaalpha signaling is regulated through the primary cilium in fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

The Na+/H+ exchanger NHE1 is required for directional migration stimulated via PDGFR-alpha in the primary cilium

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

NPHP4, a cilia-associated protein, negatively regulates the Hippo pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

Cilium-generated signaling and cilia-related disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

To beat or not to beat: roles of cilia in development and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

Ciliogenesis: building the cell's antenna

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

A motility in the eukaryotic flagellum unrelated to flagellar beating

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

21 January 2018

Intraflagellar transport

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

Flagellar motion and fine structure of the flagellar apparatus in Chlamydomonas

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

Characterization of mouse IFT complex B

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

Intraflagellar transport (IFT) cargo: IFT transports flagellar precursors to the tip and turnover products to the cell body

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

The intraflagellar transport protein IFT20 is associated with the Golgi complex and is required for cilia assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

The Golgin GMAP210/TRIP11 anchors IFT20 to the Golgi complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

Intraflagellar transport is required for polarized recycling of the TCR/CD3 complex to the immune synapse

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

Assembly of primary cilia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

Cep97 and CP110 suppress a cilia assembly program

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

CP110 suppresses primary cilia formation through its interaction with CEP290, a protein deficient in human ciliary disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

Centriolar kinesin Kif24 interacts with CP110 to remodel microtubules and regulate ciliogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

Building it up and taking it down: the regulation of vertebrate ciliogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

HEF1-dependent Aurora A activation induces disassembly of the primary cilium

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

Pitchfork regulates primary cilia disassembly and left-right asymmetry

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

The ubiquitin conjugation system is involved in the disassembly of cilia and flagella

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

Nde1-mediated inhibition of ciliogenesis affects cell cycle re-entry

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

Intraflagellar transport delivers tubulin isotypes to sensory cilium middle and distal segments

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

Soluble levels of cytosolic tubulin regulate ciliary length control

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

The major alpha-tubulin K40 acetyltransferase alphaTAT1 promotes rapid ciliogenesis and efficient mechanosensation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

The small GTPases ARL-13 and ARL-3 coordinate intraflagellar transport and ciliogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

Ciliary targeting motif VxPx directs assembly of a trafficking module through Arf4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

Coordination of Rab8 and Rab11 in primary ciliogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

Ciliary entry of the kinesin-2 motor KIF17 is regulated by importin-beta2 and RanGTP

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

The conserved Bardet-Biedl syndrome proteins assemble a coat that traffics membrane proteins to cilia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

Molecular mechanisms of protein and lipid targeting to ciliary membranes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

The cytoplasmic tail of fibrocystin contains a ciliary targeting sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

Ciliary targeting of olfactory CNG channels requires the CNGB1b subunit and the kinesin-2 motor protein, KIF17.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

Identification of ciliary localization sequences within the third intracellular loop of G protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

Cystin localizes to primary cilia via membrane microdomains and a targeting motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

Flagellar protein localization mediated by a calcium-myristoyl/palmitoyl switch mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

Sequences required for the flagellar targeting of an integral membrane protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

Polycystin-2 traffics to cilia independently of polycystin-1 by using an N-terminal RVxP motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

A septin diffusion barrier at the base of the primary cilium maintains ciliary membrane protein distribution

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

CEP290 tethers flagellar transition zone microtubules to the membrane and regulates flagellar protein content.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

MKS and NPHP modules cooperate to establish basal body/transition zone membrane associations and ciliary gate function during ciliogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

The cell biological basis of ciliary disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

Piecing together a ciliome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

The ciliary proteome database: an integrated community resource for the genetic and functional dissection of cilia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

CentrosomeDB: a human centrosomal proteins database

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

Cildb: a knowledgebase for centrosomes and cilia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

Versatile screening for binary protein-protein interactions by yeast two-hybrid mating

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

Interaction of nephrocystin-4 and RPGRIP1 is disrupted by nephronophthisis or Leber congenital amaurosis-associated mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

Tandem affinity purification of ciliopathy-associated protein complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

Positional cloning of the gene for X-linked retinitis pigmentosa 3: homology with the guanine-nucleotide-exchange factor RCC1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

The retinitis pigmentosa GTPase regulator (RPGR) interacts with novel transport-like proteins in the outer segments of rod photoreceptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

A gene (RPGR) with homology to the RCC1 guanine nucleotide exchange factor is mutated in X-linked retinitis pigmentosa (RP3)

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

A common allele in RPGRIP1L is a modifier of retinal degeneration in ciliopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

Null RPGRIP1 alleles in patients with Leber congenital amaurosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

Mutations in the gene encoding the basal body protein RPGRIP1L, a nephrocystin-4 interactor, cause Joubert syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

The gene mutated in juvenile nephronophthisis type 4 encodes a novel protein that interacts with nephrocystin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

A BBSome subunit links ciliogenesis, microtubule stability, and acetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

BBS6, BBS10, and BBS12 form a complex with CCT/TRiC family chaperonins and mediate BBSome assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

Disruption of a ciliary B9 protein complex causes Meckel syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

Nephrocystins and MKS proteins interact with IFT particle and facilitate transport of selected ciliary cargos

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

Mutations in LCA5, encoding the ciliary protein lebercilin, cause Leber congenital amaurosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

Disruption of intraflagellar protein transport in photoreceptor cilia causes Leber congenital amaurosis in humans and mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

The ciliopathy-associated protein homologs RPGRIP1 and RPGRIP1L are linked to cilium integrity through interaction with Nek4 serine/threonine kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354

Dissecting the Molecular Mechanisms of Intraflagellar Transport in Chlamydomonas

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR354