DNA repair endonuclease ERCC1-XPF as a novel therapeutic target to overcome chemoresistance in cancer therapy (Q27022940)

D. W. Melton

series ordinal

2

1 reference

language of work or name

1 reference

1 November 2012

8 references

3 April 2019

2 August 2019

20 August 2019

28 September 2019

11 December 2019

26 October 2020

8 February 2021

Nucleic Acids Research

8 references

3 April 2019

2 August 2019

20 August 2019

28 September 2019

11 December 2019

26 October 2020

8 February 2021

40

1 reference

issue

20

1 reference

page(s)

9990-10004

1 reference

Creative Commons Attribution-NonCommercial 3.0 Unported

copyright license

7 references

3 April 2019

2 August 2019

20 August 2019

28 September 2019

11 December 2019

26 October 2020

on focus list of Wikimedia project

8 February 2021

ScienceSource

0 references

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Analysis of the XPA and ssDNA-binding surfaces on the central domain of human ERCC1 reveals evidence for subfunctionalization

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First reported patient with human ERCC1 deficiency has cerebro-oculo-facio-skeletal syndrome with a mild defect in nucleotide excision repair and severe developmental failure

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XPF with mutations in its conserved nuclease domain is defective in DNA repair but functions in TRF2-mediated telomere shortening

21 March 2017

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21 March 2017

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Physical and functional interaction between the XPF/ERCC1 endonuclease and hRad52

21 March 2017

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Functional and physical interactions between ERCC1 and MSH2 complexes for resistance to cis-diamminedichloroplatinum(II) in mammalian cells

21 March 2017

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ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes

21 March 2017

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Nonerythroid alphaII spectrin is required for recruitment of FANCA and XPF to nuclear foci induced by DNA interstrand cross-links

21 March 2017

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Helicase structure and mechanism

21 March 2017

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The structure-specific endonuclease Ercc1-Xpf is required for targeted gene replacement in embryonic stem cells

21 March 2017

1 reference

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Mapping of interaction domains between human repair proteins ERCC1 and XPF

21 March 2017

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Reconstitution of human excision nuclease with recombinant XPF-ERCC1 complex

21 March 2017

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ERCC4 (XPF) encodes a human nucleotide excision repair protein with eukaryotic recombination homologs

21 March 2017

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Mutational analysis of the human nucleotide excision repair gene ERCC1

21 March 2017

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Xeroderma pigmentosum group F caused by a defect in a structure-specific DNA repair endonuclease

21 March 2017

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Specific association between the human DNA repair proteins XPA and ERCC1

21 March 2017

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The structure of the XPF-ssDNA complex underscores the distinct roles of the XPF and ERCC1 helix- hairpin-helix domains in ss/ds DNA recognition

21 March 2017

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Structural basis for the recruitment of ERCC1-XPF to nucleotide excision repair complexes by XPA

21 March 2017

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The HhH domain of the human DNA repair protein XPF forms stable homodimers

21 March 2017

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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

21 March 2017

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X-ray and biochemical anatomy of an archaeal XPF/Rad1/Mus81 family nuclease: similarity between its endonuclease domain and restriction enzymes

21 March 2017

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21 March 2017

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RAD10, an excision repair gene of Saccharomyces cerevisiae, is involved in the RAD1 pathway of mitotic recombination

21 March 2017

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Removal of nonhomologous DNA ends in double-strand break recombination: the role of the yeast ultraviolet repair gene RAD1

21 March 2017

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Human XPF controls TRF2 and telomere length maintenance through distinctive mechanisms

21 March 2017

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The active site of the DNA repair endonuclease XPF-ERCC1 forms a highly conserved nuclease motif

21 March 2017

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Activity of individual ERCC1 and XPF subunits in DNA nucleotide excision repair

21 March 2017

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A relationship betweena DNA-repair/recombination nuclease family and archaeal helicases

21 March 2017

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Physiological consequences of defects in ERCC1-XPF DNA repair endonuclease

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488251

Mammalian nucleotide excision repair proteins and interstrand crosslink repair

21 March 2017

1 reference

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ERCC1-XPF endonuclease facilitates DNA double-strand break repair

21 March 2017

1 reference

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The ERCC1/XPF endonuclease is required for efficient single-strand annealing and gene conversion in mammalian cells

21 March 2017

1 reference

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A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis

21 March 2017

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Multiple TPR motifs characterize the Fanconi anemia FANCG protein

21 March 2017

1 reference

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Recombination-dependent deletion formation in mammalian cells deficient in the nucleotide excision repair gene ERCC1

21 March 2017

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Specific cleavage of model recombination and repair intermediates by the yeast Rad1-Rad10 DNA endonuclease

21 March 2017

1 reference

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The structure-specific endonuclease Ercc1-Xpf is required to resolve DNA interstrand cross-link-induced double-strand breaks

21 March 2017

1 reference

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Growth retardation, early death, and DNA repair defects in mice deficient for the nucleotide excision repair enzyme XPF

21 March 2017

1 reference

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DNA-binding polarity of human replication protein A positions nucleases in nucleotide excision repair

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488251

Mice with DNA repair gene (ERCC-1) deficiency have elevated levels of p53, liver nuclear abnormalities and die before weaning

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488251

Transcription-coupled DNA repair: two decades of progress and surprises

21 March 2017

1 reference

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MMEJ repair of double-strand breaks (director's cut): deleted sequences and alternative endings

7 April 2017

1 reference

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Multiple DNA binding domains mediate the function of the ERCC1-XPF protein in nucleotide excision repair

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488251

Fluorescence-based incision assay for human XPF-ERCC1 activity identifies important elements of DNA junction recognition

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488251

Synthesis, biological evaluation, and structure-activity relationships of a novel class of apurinic/apyrimidinic endonuclease 1 inhibitors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488251

NMR studies reveal an unexpected binding site for a redox inhibitor of AP endonuclease 1.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488251

Cisplatin regulates the MAPK kinase pathway to induce increased expression of DNA repair gene ERCC1 and increase melanoma chemoresistance

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488251

Role of interaction of XPF with RPA in nucleotide excision repair

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488251

The knock-down of ERCC1 but not of XPF causes multinucleation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488251

Identification of DNA repair gene Ercc1 as a novel target in melanoma

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488251

DNA interstrand crosslink repair and cancer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488251

The xeroderma pigmentosum pathway: decision tree analysis of DNA quality

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488251

Complementary non-radioactive assays for investigation of human flap endonuclease 1 activity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488251

Multiple roles of the ERCC1-XPF endonuclease in DNA repair and resistance to anticancer drugs

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488251

Cisplatin sensitivity of testis tumour cells is due to deficiency in interstrand-crosslink repair and low ERCC1-XPF expression

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488251

Localization of xeroderma pigmentosum group A protein and replication protein A on damaged DNA in nucleotide excision repair

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488251

The Fanconi anemia protein, FANCG, binds to the ERCC1-XPF endonuclease via its tetratricopeptide repeats and the central domain of ERCC1.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488251

Downregulation of XPF-ERCC1 enhances cisplatin efficacy in cancer cells.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488251

Mislocalization of XPF-ERCC1 nuclease contributes to reduced DNA repair in XP-F patients

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488251

The XPA-binding domain of ERCC1 is required for nucleotide excision repair but not other DNA repair pathways

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488251

XPF-ERCC1 participates in the Fanconi anemia pathway of cross-link repair.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488251

Characterization of an inhibitory dynamic pharmacophore for the ERCC1-XPA interaction using a combined molecular dynamics and virtual screening approach.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488251

ERCC1 expression as a predictive marker of squamous cell carcinoma of the head and neck treated with cisplatin-based concurrent chemoradiation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488251

ERCC1 and BRCA1 mRNA expression levels in metastatic malignant effusions is associated with chemosensitivity to cisplatin and/or docetaxel

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488251

Impacts of excision repair cross-complementing gene 1 (ERCC1), dihydropyrimidine dehydrogenase, and epidermal growth factor receptor on the outcomes of patients with advanced gastric cancer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488251

ERK1/2 is highly phosphorylated in melanoma metastases and protects melanoma cells from cisplatin-mediated apoptosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488251

Gene expression of ERCC1 as a novel prognostic marker in advanced bladder cancer patients receiving cisplatin-based chemotherapy.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488251

DNA repair by ERCC1 in non-small-cell lung cancer and cisplatin-based adjuvant chemotherapy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488251

Recognition of helical kinks by xeroderma pigmentosum group A protein triggers DNA excision repair

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488251

Fanconi anemia (cross)linked to DNA repair

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488251

The structure of the human ERCC1/XPF interaction domains reveals a complementary role for the two proteins in nucleotide excision repair

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488251

Polymorphisms of DNA repair genes and risk of non-small cell lung cancer.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488251

ERCC1 expression is a predictor of survival in resected patients with non-small cell lung cancer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488251

The identification and optimization of a N-hydroxy urea series of flap endonuclease 1 inhibitors.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488251

Yeast Mre11 and Rad1 proteins define a Ku-independent mechanism to repair double-strand breaks lacking overlapping end sequences

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488251

hMutSbeta is required for the recognition and uncoupling of psoralen interstrand cross-links in vitro

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488251

Repair of an interstrand DNA cross-link initiated by ERCC1-XPF repair/recombination nuclease.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488251

Cell cycle checkpoint abrogator UCN-01 inhibits DNA repair: association with attenuation of the interaction of XPA and ERCC1 nucleotide excision repair proteins.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488251

Physical interaction between components of DNA mismatch repair and nucleotide excision repair

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488251

DNA structural elements required for ERCC1-XPF endonuclease activity.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488251

Replication protein A confers structure-specific endonuclease activities to the XPF-ERCC1 and XPG subunits of human DNA repair excision nuclease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488251

Mutations in XPA that prevent association with ERCC1 are defective in nucleotide excision repair

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488251

Mammalian DNA nucleotide excision repair reconstituted with purified protein components.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488251

Molecular characterization of the human excision repair gene ERCC-1: cDNA cloning and amino acid homology with the yeast DNA repair gene RAD10.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488251

Identification of specific inhibitors of human RAD51 recombinase using high-throughput screening

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488251

Structure of an XPF endonuclease with and without DNA suggests a model for substrate recognition.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488251

The yeast DNA repair proteins RAD1 and RAD7 share similar putative functional domains.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488251

Xeroderma pigmentosum group F protein binds to Eg5 and is required for proper mitosis: implications for XP-F and XFE.

31 May 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKS818

Prognostic value of expression of ERCC1, thymidylate synthase, and glutathione S-transferase P1 for 5-fluorouracil/oxaliplatin chemotherapy in advanced gastric cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKS818

ERCC1 predicting chemoradiation resistance and poor outcome in oesophageal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKS818

Cisplatin induction of ERCC-1 mRNA expression in A2780/CP70 human ovarian cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKS818

GATA-1 is essential in EGF-mediated induction of nucleotide excision repair activity and ERCC1 expression through ERK2 in human hepatoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKS818

Biophysical characterization of the interaction domains and mapping of the contact residues in the XPF-ERCC1 complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKS818

Crystal structure and functional implications of Pyrococcus furiosus hef helicase domain involved in branched DNA processing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKS818

SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKS818

XPF nuclease-dependent telomere loss and increased DNA damage in mice overexpressing TRF2 result in premature aging and cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKS818

Role of reciprocal exchange, one-ended invasion crossover and single-strand annealing on inverted and direct repeat recombination in yeast: different requirements for the RAD1, RAD10, and RAD52 genes

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488251

28 November 2018

XPF-ERCC1: on the bubble

1 reference

https://pubmed.ncbi.nlm.nih.gov/22941649

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The identification and optimization of 2,4-diketobutyric acids as flap endonuclease 1 inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/22941649

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/NAR/GKS818

1 reference

release_lzd4sktf7nem3g2mxn3wb2aaqe

1267642

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/lzd4sktf7nem3g2mxn3wb2aaqe

mapped directly with Wikidata item

24 November 2022

based on heuristic

1267642

1 reference

1 reference

1 reference