ITC recommendations for transporter kinetic parameter estimation and translational modeling of transport-mediated PK and DDIs in humans (Q27022933)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23588311%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

title

ITC recommendations for transporter kinetic parameter estimation and translational modeling of transport-mediated PK and DDIs in humans (English)

1 reference

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28 February 2020

11

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28 February 2020

Peter W. Swaan

13

1 reference

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28 February 2020

Aleksandra Galetin

16

1 reference

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28 February 2020

author name string

M J Zamek-Gliszczynski

1

2 references

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28 February 2020

C A Lee

2

2 references

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28 February 2020

A Poirier

3

2 references

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28 February 2020

J Bentz

4

2 references

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28 February 2020

X Chu

5

2 references

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28 February 2020

H Ellens

6

2 references

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28 February 2020

T Ishikawa

7

2 references

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28 February 2020

M Jamei

8

2 references

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28 February 2020

J C Kalvass

9

2 references

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28 February 2020

S Nagar

10

2 references

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28 February 2020

K Korzekwa

12

2 references

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28 February 2020

M E Taub

14

2 references

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28 February 2020

P Zhao

15

2 references

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28 February 2020

International Transporter Consortium

17

1 reference

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28 February 2020

language of work or name

1 reference

25 February 2013

1 reference

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Clinical Pharmacology & Therapeutics

28 February 2020

published in

2 references

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28 February 2020

volume

94

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28 February 2020

page(s)

64-79

2 references

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28 February 2020

issue

1

2 references

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Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver

28 February 2020

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28 September 2017

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Prediction of pharmacokinetic profile of valsartan in human based on in vitro uptake transport data

28 September 2017

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If the KI is defined by the free energy of binding to P-glycoprotein, which kinetic parameters define the IC50 for the Madin-Darby canine kidney II cell line overexpressing human multidrug resistance 1 confluent cell monolayer?

28 September 2017

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28 September 2017

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Breast cancer resistance protein interacts with various compounds in vitro, but plays a minor role in substrate efflux at the blood-brain barrier

28 September 2017

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28 September 2017

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Multiple inhibition mechanisms and prediction of drug-drug interactions: status of metabolism and transporter models as exemplified by gemfibrozil-drug interactions.

28 September 2017

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28 September 2017

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Xenobiotic transporters: ascribing function from gene knockout and mutation studies

28 September 2017

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Pharmacokinetics and pharmacodynamics of seven opioids in P-glycoprotein-competent mice: assessment of unbound brain EC50,u and correlation of in vitro, preclinical, and clinical data

28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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Prediction of the pharmacokinetics of atorvastatin, cerivastatin, and indomethacin using kinetic models applied to isolated rat hepatocytes

31 May 2018

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Investigation of the rate-determining process in the hepatic elimination of HMG-CoA reductase inhibitors in rats and humans

31 May 2018

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Efflux ratio cannot assess P-glycoprotein-mediated attenuation of absorptive transport: asymmetric effect of P-glycoprotein on absorptive and secretory transport across Caco-2 cell monolayers

21 January 2018

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Kinetic considerations for the quantitative assessment of efflux activity and inhibition: implications for understanding and predicting the effects of efflux inhibition.

21 January 2018

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Model analysis of the concentration-dependent permeability of P-gp substrates

21 January 2018

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Permeability, transport, and metabolism of solutes in Caco-2 cell monolayers: a theoretical study.

21 January 2018

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Digoxin is not a substrate for organic anion-transporting polypeptide transporters OATP1A2, OATP1B1, OATP1B3, and OATP2B1 but is a substrate for a sodium-dependent transporter expressed in HEK293 cells.

21 January 2018

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Cyclosporine inhibition of hepatic and intestinal CYP3A4, uptake and efflux transporters: application of PBPK modeling in the assessment of drug-drug interaction potential

21 January 2018

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Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats using loperamide, paclitaxel, sulfasalazine, and carboxydichlorofluorescein pharmacokinetics.

21 January 2018

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Kinetic analysis of the cooperation of P-glycoprotein (P-gp/Abcb1) and breast cancer resistance protein (Bcrp/Abcg2) in limiting the brain and testis penetration of erlotinib, flavopiridol, and mitoxantrone

21 January 2018

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Relationship between drug/metabolite exposure and impairment of excretory transport function.

21 January 2018

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An unexpected synergist role of P-glycoprotein and breast cancer resistance protein on the central nervous system penetration of the tyrosine kinase inhibitor lapatinib (N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amin

21 January 2018

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Screening of OATP1B1/3 and OCT1 inhibitors in cryopreserved hepatocytes in suspension

21 January 2018

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Disposition of oral and intravenous pravastatin in MRP2-deficient TR- rats

21 January 2018

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Targeted disruption of the multidrug and toxin extrusion 1 (mate1) gene in mice reduces renal secretion of metformin

21 January 2018

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Commentary: theoretical predictions of flow effects on intestinal and systemic availability in physiologically based pharmacokinetic intestine models: the traditional model, segregated flow model, and QGut model.

21 January 2018

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Prediction of human renal clearance from preclinical species for a diverse set of drugs that exhibit both active secretion and net reabsorption

21 January 2018

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Mechanistic modeling of hepatic transport from cells to whole body: application to napsagatran and fexofenadine

21 January 2018

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Segmental intestinal transporters and metabolic enzymes on intestinal drug absorption.

21 January 2018

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Physiologically based pharmacokinetic modeling of intestinal first-pass metabolism of CYP3A substrates with high intestinal extraction.

21 January 2018

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Development of a physiologically based pharmacokinetic model for the rat central nervous system and determination of an in vitro-in vivo scaling methodology for the blood-brain barrier permeability of two transporter substrates, morphine and oxycodo

21 January 2018

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Simultaneous absolute protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases as a novel approach for the characterization of individual human liver: comparison with mRNA levels and activities.

21 January 2018

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Kinetic characterization of rat hepatic uptake of 16 actively transported drugs

21 January 2018

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Method for predicting the risk of drug-drug interactions involving inhibition of intestinal CYP3A4 and P-glycoprotein.

21 January 2018

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Physiologically Based Modeling of Pravastatin Transporter-Mediated Hepatobiliary Disposition and Drug-Drug Interactions

21 January 2018

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Hepatic uptake of bromosulfophthalein-glutathione in perfused Eisai hyperbilirubinemic mutant rat liver: a multiple-indicator dilution study.

21 January 2018

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Ablation of both organic cation transporter (OCT)1 and OCT2 alters metformin pharmacokinetics but has no effect on tissue drug exposure and pharmacodynamics

28 November 2018

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12 December 2020

Organic anion-transporting polypeptides 1a/1b control the hepatic uptake of pravastatin in mice

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12 December 2020

Highlights from the International Transporter Consortium second workshop

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12 December 2020

Metabolism and disposition of the antifolate LY231514 in mice and dogs

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12 December 2020

Physiologically based pharmacokinetics of cyclosporine A: extension to tissue distribution kinetics in rats and scale-up to human

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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Identifiers

DOI

10.1038/CLPT.2013.45

2 references

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28 February 2020

1 reference

2 references

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28 February 2020

2 references