Structural organization of intercellular channels II. Amino terminal domain of the connexins: sequence, functional roles, and structure (Q27009167)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22037495%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

title

Structural organization of intercellular channels II. Amino terminal domain of the connexins: sequence, functional roles, and structure (English)

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15 January 2020

1

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15 January 2020

author name string

Gregory M Lipkind

series ordinal

2

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15 January 2020

John W Kyle

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3

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15 January 2020

Viviana M Berthoud

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4

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15 January 2020

language of work or name

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20 October 2011

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Biochimica et Biophysica Acta

15 January 2020

published in

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15 January 2020

volume

1818

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15 January 2020

issue

8

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15 January 2020

page(s)

1823-1830

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Composition and biological significance of the human Nα-terminal acetyltransferases

15 January 2020

cites work

1 reference

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Mutations in the human connexin gene GJB3 cause erythrokeratodermia variabilis

21 March 2017

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Connexin43: a protein from rat heart homologous to a gap junction protein from liver

21 March 2017

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Structure of the connexin 26 gap junction channel at 3.5 A resolution

21 March 2017

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Functional studies of human skin disease- and deafness-associated connexin 30 mutations

21 March 2017

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Voltage-dependent conformational changes in connexin channels

21 March 2017

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Towards a functional understanding of protein N-terminal acetylation

28 September 2017

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Post-translational modifications of connexin26 revealed by mass spectrometry

28 September 2017

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Phosphorylation and truncation sites of bovine lens connexin 46 and connexin 50.

28 September 2017

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The N terminus of connexin37 contains an alpha-helix that is required for channel function.

28 September 2017

1 reference

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An intact connexin N-terminus is required for function but not gap junction formation

28 September 2017

1 reference

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Projection structure of a N-terminal deletion mutant of connexin 26 channel with decreased central pore density

28 September 2017

1 reference

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Posttranslational modifications in lens fiber connexins identified by off-line-HPLC MALDI-quadrupole time-of-flight mass spectrometry

28 September 2017

1 reference

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Cataracts are caused by alterations of a critical N-terminal positive charge in connexin50

28 September 2017

1 reference

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Three-dimensional structure of a human connexin26 gap junction channel reveals a plug in the vestibule

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298602

Role of the N-terminus in permeability of chicken connexin45.6 gap junctional channels

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298602

A novel N14Y mutation in Connexin26 in keratitis-ichthyosis-deafness syndrome: analyses of altered gap junctional communication and molecular structure of N terminus of mutated Connexin26.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298602

Structural determinants for the differences in voltage gating of chicken Cx56 and Cx45.6 gap-junctional hemichannels

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298602

N-terminal residues in Cx43 and Cx40 determine physiological properties of gap junction channels, but do not influence heteromeric assembly with each other or with Cx26.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298602

Isoelectric points and post-translational modifications of connexin26 and connexin32.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298602

The vertebrate connexin family

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298602

An amino-terminal lysine residue of rat connexin40 that is required for spermine block

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298602

Exchange of gating properties between rat cx46 and chicken cx45.6.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298602

Determinants of gating polarity of a connexin 32 hemichannel

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298602

Voltage-dependent blockade of connexin40 gap junctions by spermine

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298602

Missense mutations in GJB2 encoding connexin-26 cause the ectodermal dysplasia keratitis-ichthyosis-deafness syndrome

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298602

Functional alterations in gap junction channels formed by mutant forms of connexin 32: evidence for loss of function as a pathogenic mechanism in the X-linked form of Charcot-Marie-Tooth disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298602

Reversal of the gating polarity of gap junctions by negative charge substitutions in the N-terminus of connexin 32

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298602

Identification of a pore lining segment in gap junction hemichannels.

28 September 2017

1 reference

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Molecular cloning of cDNA for rat liver gap junction protein

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298602

Sequence and tissue distribution of a second protein of hepatic gap junctions, Cx26, as deduced from its cDNA

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298602

Antisera directed against connexin43 peptides react with a 43-kD protein localized to gap junctions in myocardium and other tissues

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298602

The 43-kD polypeptide of heart gap junctions: immunolocalization, topology, and functional domains

28 September 2017

1 reference

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Topological distribution of two connexin32 antigenic sites in intact and split rodent hepatocyte gap junctions

28 September 2017

1 reference

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Molecular biology and genetics of gap junction channels

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298602

Structural studies of the N-terminus of Connexin 32 using 1H NMR spectroscopy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298602

Charges dispersed over the permeation pathway determine the charge selectivity and conductance of a Cx32 chimeric hemichannel

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298602

Structure of the amino terminus of a gap junction protein

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298602

Connexin 32 of gap junctions contains two cytoplasmic calmodulin-binding domains

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298602

Opposite voltage gating polarities of two closely related connexins.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298602

Connexin 26 (GJB2) mutations, causing KID Syndrome, are associated with cell death due to calcium gating deregulation.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298602

A report of GJB2 (N14K) Connexin 26 mutation in two patients--a new subtype of KID syndrome?

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298602

Calmodulin association with connexin32-derived peptides suggests trans-domain interaction in chemical gating of gap junction channels

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298602

Differential potency of dominant negative connexin43 mutants in oculodentodigital dysplasia.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298602

Knock-in of alpha3 connexin prevents severe cataracts caused by an alpha8 point mutation

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298602

Inversion of both gating polarity and CO2 sensitivity of voltage gating with D3N mutation of Cx50.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298602

Oculodentodigital dysplasia-causing connexin43 mutants are non-functional and exhibit dominant effects on wild-type connexin43.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298602

Amino terminal glutamate residues confer spermine sensitivity and affect voltage gating and channel conductance of rat connexin40 gap junctions

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298602

Specific amino-acid residues in the N-terminus and TM3 implicated in channel function and oligomerization compatibility of connexin43.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298602

Evidence for a role of the N-terminal domain in subcellular localization of the neuronal connexin36 (Cx36).

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298602

The topological structure of connexin 26 and its distribution compared to connexin 32 in hepatic gap junctions.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298602

Topography of connexin32 in rat liver gap junctions. Evidence for an intramolecular disulphide linkage connecting the two extracellular peptide loops

28 November 2018

1 reference

12 December 2020

The cardiac gap junction protein (Mr 47,000) has a tissue-specific cytoplasmic domain of Mr 17,000 at its carboxy-terminus

1 reference

12 December 2020

Topology of the Mr 27,000 liver gap junction protein. Cytoplasmic localization of amino- and carboxyl termini and a hydrophilic domain which is protease-hypersensitive

1 reference

12 December 2020

Altered trafficking of mutant connexin32

1 reference

12 December 2020

Functional Characterization of Connexin43 Mutations Found in Patients With Oculodentodigital Dysplasia

1 reference

12 December 2020

Topological analysis of the major protein in isolated intact rat liver gap junctions and gap junction-derived single membrane structures

1 reference

12 December 2020

Homologies between gap junction proteins in lens, heart and liver

1 reference

12 December 2020

10.1016/J.BBAMEM.2011.10.011

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15 January 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22037495%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

2 references