Toxin-based targeted therapy for malignant brain tumors (Q27006226)

author name string

Vidyalakshmi Chandramohan

series ordinal

1

1 reference

John H. Sampson

series ordinal

2

1 reference

language of work or name

1 reference

2012

1 reference

Clinical and Developmental Immunology

9 February 2012

6 references

3 April 2019

25 April 2019

25 June 2019

27 November 2019

13 December 2019

13 November 2020

7 references

3 April 2019

25 April 2019

25 June 2019

27 November 2019

13 December 2019

13 November 2020

2012

1 reference

page(s)

480429

1 reference

Creative Commons Attribution 3.0 Unported

copyright license

6 references

3 April 2019

25 April 2019

25 June 2019

27 November 2019

13 December 2019

on focus list of Wikimedia project

13 November 2020

copyright status

copyrighted

0 references

ScienceSource

0 references

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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In situ expression of interleukin-4 (IL-4) receptors in human brain tumors and cytotoxicity of a recombinant IL-4 cytotoxin in primary glioblastoma cell cultures

28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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A tiger behind many doors: multiple genetic pathways to malignant glioma

28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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Structure of exotoxin A of Pseudomonas aeruginosa at 3.0-Angstrom resolution

28 September 2017

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Applications of monoclonal antibodies in the diagnosis and treatment of primary brain tumors

28 September 2017

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28 September 2017

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Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas

28 September 2017

1 reference

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Anti-synthetic peptide antibody reacting at the fusion junction of deletion-mutant epidermal growth factor receptors in human glioblastoma

28 September 2017

1 reference

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Amplified cellular oncogenes in neoplasms of the human central nervous system

28 September 2017

1 reference

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The Clinical Significance of Epidermal Growth Factor Receptor (EGF-R) in Human Breast Cancer: A Review on 5232 Patients*

28 September 2017

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28 September 2017

Epidermal Growth Factor

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Genetically engineering transferrin to improve its in vitro ability to deliver cytotoxins

28 September 2017

1 reference

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Safety, tolerability, and tumor response of IL4-Pseudomonas exotoxin (NBI-3001) in patients with recurrent malignant glioma.

31 May 2018

1 reference

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Intratumoral administration of recombinant circularly permuted interleukin-4-Pseudomonas exotoxin in patients with high-grade glioma.

31 May 2018

1 reference

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Immunotoxins that target an oncogenic mutant epidermal growth factor receptor expressed in human tumors.

31 May 2018

1 reference

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Tumor regression with regional distribution of the targeted toxin TF-CRM107 in patients with malignant brain tumors.

31 May 2018

1 reference

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Intraventricular immunotoxin therapy for leptomeningeal neoplasia.

31 May 2018

1 reference

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Preclinical development of a recombinant toxin containing circularly permuted interleukin 4 and truncated Pseudomonas exotoxin for therapy of malignant astrocytoma.

31 May 2018

1 reference

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Efficacy of transferrin receptor-targeted immunotoxins in brain tumor cell lines and pediatric brain tumors

31 May 2018

1 reference

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Evidence for involvement of furin in cleavage and activation of diphtheria toxin

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287048

Human renal cell carcinoma cells are sensitive to the cytotoxic effect of a chimeric protein composed of human interleukin-4 and Pseudomonas exotoxin

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287048

Receptor for interleukin 13. Interaction with interleukin 4 by a mechanism that does not involve the common gamma chain shared by receptors for interleukins 2, 4, 7, 9, and 15.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287048

Transforming growth factor and epidermal growth factor stimulate the phosphorylation of a synthetic, tyrosine-containing peptide in a similar manner

31 May 2018

1 reference

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Expression of epidermal growth factor receptors in human brain tumors

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287048

The mechanism of action of ricin and related toxic lectins on eukaryotic ribosomes. The site and the characteristics of the modification in 28 S ribosomal RNA caused by the toxins.

31 May 2018

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Mutations in diphtheria toxin separate binding from entry and amplify immunotoxin selectivity

31 May 2018

1 reference

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Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin.

31 May 2018

1 reference

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Improved tumor-specific immunotoxins in the treatment of CNS and leptomeningeal neoplasia

31 May 2018

1 reference

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Potent cytotoxicity of an antihuman transferrin receptor-ricin A-chain immunotoxin on human glioma cells in vitro

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287048

Effects of treatment on long-term survivors with malignant astrocytomas.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287048

Correlation of chondroitin sulfate proteoglycan expression on proliferating brain capillary endothelial cells with the malignant phenotype of astroglial cells

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287048

Expression cloning of a diphtheria toxin receptor: identity with a heparin-binding EGF-like growth factor precursor.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287048

Cell surface and intracellular functions for ricin galactose binding.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287048

EGF receptor amplification and expression in human brain tumours

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287048

Increased antitumor activity of a circularly permuted interleukin 4-toxin in mice with interleukin 4 receptor-bearing human carcinoma.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287048

Functional domains of Pseudomonas exotoxin identified by deletion analysis of the gene expressed in E. coli.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287048

Functional analysis of domains II, Ib, and III of Pseudomonas exotoxin.

19 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287048

Intracranial therapy of glioblastoma with the fusion protein DTIL13 in immunodeficient mice.

19 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287048

Cytotoxicity and antitumor effects of growth factor-toxin fusion proteins on human glioblastoma multiforme cells.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287048

Combination intraventricular chemotherapy for meningeal neoplasia.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287048

Potent and specific killing of human malignant brain tumor cells by an anti-transferrin receptor antibody-ricin immunotoxin.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287048

Epidermal growth factor receptor in human glioma.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287048

The effect of extent of resection on time to tumor progression and survival in patients with glioblastoma multiforme of the cerebral hemisphere.

28 July 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F480429

Hypothalamic-pituitary dysfunction after radiation for brain tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F480429

Direct intracerebral delivery of cintredekin besudotox (IL13-PE38QQR) in recurrent malignant glioma: a report by the Cintredekin Besudotox Intraparenchymal Study Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F480429

Progress report of a Phase I study of the intracerebral microinfusion of a recombinant chimeric protein composed of transforming growth factor (TGF)-alpha and a mutated form of the Pseudomonas exotoxin termed PE-38 (TP-38) for the treatment of malig

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F480429

Efficacy of direct intratumoral therapy with targeted protein toxins for solid human gliomas in nude mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F480429

Analysis of interleukin-13 receptor alpha2 expression in human pediatric brain tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F480429

Intratumoral immunotoxin treatment of human malignant brain tumors in immunodeficient animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F480429

The class III variant of the epidermal growth factor receptor (EGFRvIII): characterization and utilization as an immunotherapeutic target.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F480429

Unified Nomenclature for Eph Family Receptors and Their Ligands, the Ephrins

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F480429

Targeting urokinase-type plasminogen activator receptor on human glioblastoma tumors with diphtheria toxin fusion protein DTAT.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F480429

Evaluation of a bispecific biological drug designed to simultaneously target glioblastoma and its neovasculature in the brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F480429

A bispecific immunotoxin (DTAT13) targeting human IL-13 receptor (IL-13R) and urokinase-type plasminogen activator receptor (uPAR) in a mouse xenograft model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F480429

Local convection enhanced delivery of IL4-Pseudomonas exotoxin (NBI-3001) for treatment of patients with recurrent malignant glioma

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287048

Identification and characterization of interleukin-13 receptor in human medulloblastoma and targeting these receptors with interleukin-13-pseudomonas exotoxin fusion protein.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287048

Interleukin-13 receptor-targeted cancer therapy in an immunodeficient animal model of human head and neck cancer

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287048

Expression profiles of ErbB family receptors and prognosis in primary transitional cell carcinoma of the urinary bladder.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287048

Long term response in a patient with neoplastic meningitis secondary to melanoma treated with (131)I-radiolabeled antichondroitin proteoglycan sulfate Mel-14 F(ab')(2): a case study.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287048

Regional treatment of epidermal growth factor receptor vIII-expressing neoplastic meningitis with a single-chain immunotoxin, MR-1.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287048

Receptor for interleukin 13 is a marker and therapeutic target for human high-grade gliomas.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287048

Human glioma cells overexpress receptors for interleukin 13 and are extremely sensitive to a novel chimeric protein composed of interleukin 13 and pseudomonas exotoxin.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287048

Epidermal growth factor ligand-independent, unregulated, cell-transforming potential of a naturally occurring human mutant EGFRvIII gene.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287048

Quantitative immunohistochemical analysis of transforming growth factor-alpha and epidermal growth factor receptor in patients with squamous cell carcinoma of the head and neck

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287048

Monoclonal antibodies against EGFRvIII are tumor specific and react with breast and lung carcinomas and malignant gliomas.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287048

Anti-transferrin receptor monoclonal antibody and toxin–antibody conjugates affect growth of human tumour cells

28 November 2018

1 reference

12 December 2020

The alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein binds and internalizes Pseudomonas exotoxin A

1 reference

12 December 2020

Evidence for a role of EGF receptor in the progression of human lung carcinoma

1 reference

12 December 2020

Expression of high-affinity IL-4 receptors on human melanoma, ovarian and breast carcinoma cells

1 reference

12 December 2020

Human neurological cancer cells express interleukin-4 (IL-4) receptors which are targets for the toxic effects of IL4-Pseudomonas exotoxin chimeric protein

1 reference

12 December 2020

Prognostic value of c-erbB-2 and epidermal growth factor receptor in stage A1 (Tla) prostatic adenocarcinoma

1 reference

12 December 2020

Phase I studies of treatment of malignant gliomas and neoplastic meningitis with 131I-radiolabeled monoclonal antibodies anti-tenascin 81C6 and anti-chondroitin proteoglycan sulfate Me1-14 F (ab')2--a preliminary report

1 reference

12 December 2020

The IL-13 receptor structure differs on various cell types and may share more than one component with IL-4 receptor

1 reference

12 December 2020

Complete regression of established human glioblastoma tumor xenograft by interleukin-4 toxin therapy

1 reference

12 December 2020

Transferrin receptors: Structure and function

1 reference

12 December 2020

Expression of epidermal growth factor receptor in human gastric and colonic carcinomas

1 reference

12 December 2020

Receptor for interleukin 13 on AIDS-associated Kaposi's sarcoma cells serves as a new target for a potent Pseudomonas exotoxin-based chimeric toxin protein

1 reference

12 December 2020

Diphtheria toxin-dependent adenosine diphosphate ribosylation of aminoacyl transferase II and inhibition of protein synthesis

1 reference

12 December 2020

Selective destruction of target cells by diphtheria toxin conjugated to antibody directed against antigens on the cells

1 reference

12 December 2020

Effects of ricin on the ribosomal sites involved in the interaction of the elongation factors

1 reference

12 December 2020

One molecule of diphtheria toxin fragment A introduced into a cell can kill the cell

1 reference

12 December 2020

Entry of lethal doses of abrin, ricin and modeccin into the cytosol of HeLa cells

1 reference

12 December 2020

Common human melanoma-associated antigen(s) detected by monoclonal antibodies

1 reference

12 December 2020

Identification of phosphotyrosine as a product of epidermal growth factor-activated protein kinase in A-431 cell membranes

1 reference

12 December 2020