Narcolepsy: neural mechanisms of sleepiness and cataplexy (Q27004322)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22956821%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

title

Narcolepsy: neural mechanisms of sleepiness and cataplexy (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22956821%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

0 references

0 references

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22956821%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

author name string

Thomas E Scammell

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22956821%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

language of work or name

1 reference

1 September 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22956821%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

published in

Journal of Neuroscience

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22956821%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

volume

32

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22956821%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

issue

36

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22956821%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

page(s)

12305-12311

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22956821%20AND%20SRC:MED&resulttype=core&format=json

Narcolepsy is strongly associated with the T-cell receptor alpha locus

12 February 2020

cites work

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English translations of the first clinical reports on narcolepsy and cataplexy by Westphal and Gélineau in the late 19th century, with commentary

21 March 2017

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Activity of dorsal raphe cells across the sleep-waking cycle and during cataplexy in narcoleptic dogs

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A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains

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The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene

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The clinical features of cataplexy: A questionnaire study in narcolepsy patients with and without hypocretin-1 deficiency

21 March 2017

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Neural substrates of awakening probed with optogenetic control of hypocretin neurons

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Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation

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Neurons containing hypocretin (orexin) project to multiple neuronal systems

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Predictors of hypocretin (orexin) deficiency in narcolepsy without cataplexy

7 April 2017

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Increased incidence and clinical picture of childhood narcolepsy following the 2009 H1N1 pandemic vaccination campaign in Finland

28 September 2017

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Orexin / hypocretin 1 receptor antagonist reduces heroin self-administration and cue-induced heroin seeking

28 September 2017

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Neuropeptides controlling energy balance: orexins and neuromedins

28 September 2017

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Acute optogenetic silencing of orexin/hypocretin neurons induces slow-wave sleep in mice.

28 September 2017

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Reward-seeking behavior in human narcolepsy

28 September 2017

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Pharmacogenetic modulation of orexin neurons alters sleep/wakefulness states in mice

28 September 2017

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Connectomics of orexin-producing neurons: interface of systems of emotion, energy homeostasis and arousal

28 September 2017

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Orexin gene transfer into zona incerta neurons suppresses muscle paralysis in narcoleptic mice

28 September 2017

1 reference

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Orexin receptor 2 expression in the posterior hypothalamus rescues sleepiness in narcoleptic mice

28 September 2017

1 reference

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Orexin/hypocretin plays a role in the response to physiological disequilibrium

28 September 2017

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Projection neurons from the central nucleus of the amygdala to the nucleus pontis oralis

28 September 2017

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Clinical and therapeutic aspects of childhood narcolepsy-cataplexy: a retrospective study of 51 children

28 September 2017

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Modafinil for narcolepsy: systematic review and meta-analysis.

28 September 2017

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Anti-Tribbles homolog 2 autoantibodies in Japanese patients with narcolepsy

28 September 2017

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Anti-Tribbles homolog 2 (TRIB2) autoantibodies in narcolepsy are associated with recent onset of cataplexy

28 September 2017

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Role of orexin/hypocretin in reward-seeking and addiction: implications for obesity

28 September 2017

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Abnormal sleep/wake dynamics in orexin knockout mice

28 September 2017

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Elevated Tribbles homolog 2-specific antibody levels in narcolepsy patients

28 September 2017

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Loss of hypocretin (orexin) neurons with traumatic brain injury

28 September 2017

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Lateral hypothalamic orexin/hypocretin neurons: A role in reward-seeking and addiction.

28 September 2017

1 reference

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Localized loss of hypocretin (orexin) cells in narcolepsy without cataplexy

28 September 2017

1 reference

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Animal models of narcolepsy

28 September 2017

1 reference

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Integrative physiology of orexins and orexin receptors

28 September 2017

1 reference

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Differential effects of acute and repeat dosing with the H3 antagonist GSK189254 on the sleep-wake cycle and narcoleptic episodes in Ox-/- mice

28 September 2017

1 reference

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Feeding-elicited cataplexy in orexin knockout mice.

28 September 2017

1 reference

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A consensus definition of cataplexy in mouse models of narcolepsy.

28 September 2017

1 reference

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Orexin (hypocretin) gene transfer diminishes narcoleptic sleep behavior in mice

28 September 2017

1 reference

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Hypocretin/orexin disturbances in neurological disorders

28 September 2017

1 reference

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An inverse agonist of the histamine H(3) receptor improves wakefulness in narcolepsy: studies in orexin-/- mice and patients

28 September 2017

1 reference

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Systemic and nasal delivery of orexin-A (Hypocretin-1) reduces the effects of sleep deprivation on cognitive performance in nonhuman primates.

28 September 2017

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Running promotes wakefulness and increases cataplexy in orexin knockout mice

28 September 2017

1 reference

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Pathophysiology of REM sleep behaviour disorder and relevance to neurodegenerative disease

28 September 2017

1 reference

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Emerging therapies in narcolepsy-cataplexy.

28 September 2017

1 reference

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Concomitant loss of dynorphin, NARP, and orexin in narcolepsy

28 September 2017

1 reference

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Behavioral state instability in orexin knock-out mice.

28 September 2017

1 reference

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28 September 2017

1 reference

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Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice

28 September 2017

1 reference

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Cataplexy: 'tonic immobility' rather than 'REM-sleep atonia'?

28 September 2017

1 reference

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Lateral hypothalamic neuropeptides in reward and drug addiction

28 September 2017

1 reference

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The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias

28 September 2017

1 reference

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Increased dopaminergic transmission mediates the wake-promoting effects of CNS stimulants

28 September 2017

1 reference

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Dopaminergic role in stimulant-induced wakefulness.

28 September 2017

1 reference

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Hypothalamic arousal regions are activated during modafinil-induced wakefulness.

28 September 2017

1 reference

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Reduced number of hypocretin neurons in human narcolepsy

28 September 2017

1 reference

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Pharmacological aspects of human and canine narcolepsy

28 September 2017

1 reference

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DQB1*0602 and DQA1*0102 (DQ1) are better markers than DR2 for narcolepsy in Caucasian and black Americans.

28 September 2017

1 reference

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Fluvoxamine and clomipramine in the treatment of cataplexy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449314

Narcolepsy-cataplexy in a female dog

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449314

Differential effects of GABAB receptor subtypes, {gamma}-hydroxybutyric Acid, and Baclofen on EEG activity and sleep regulation

28 September 2017

1 reference

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A putative flip-flop switch for control of REM sleep

31 May 2018

1 reference

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Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null mice: molecular genetic dissection of Non-REM and REM sleep regulatory processes

31 May 2018

1 reference

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31 May 2018

1 reference

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Orexins/hypocretins excite basal forebrain cholinergic neurones

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449314

Orexin A but not orexin B rapidly enters brain from blood by simple diffusion.

31 May 2018

1 reference

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A novel HLA DR17,DQ1 (DQA1-0102/DQB1-0602 positive) haplotype predisposing to narcolepsy in Caucasians.

31 May 2018

1 reference

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Homeostasis and narcolepsy.

31 May 2018

1 reference

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Effect of inhibitory amino acid antagonists on IPSPs induced in lumbar motoneurons upon stimulation of the nucleus reticularis gigantocellularis during active sleep.

31 May 2018

1 reference

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Heart rate and blood pressure changes during sleep-waking cycles and cataplexy in narcoleptic dogs

31 May 2018

1 reference

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Sleep deprivation in narcoleptic subjects: effect on sleep stages and EEG power density.

31 May 2018

1 reference

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Effects of imipramine, chlorimipramine, and fluoxetine on cataplexy in dogs

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449314

Pitolisant, an inverse agonist of the histamine H3 receptor: an alternative stimulant for narcolepsy-cataplexy in teenagers with refractory sleepiness.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449314

Excitatory projections from the amygdala to neurons in the nucleus pontis oralis in the rat: an intracellular study.

28 November 2018

1 reference

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Obesity accompanies narcolepsy with cataplexy but not narcolepsy without cataplexy.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449314

Sodium oxybate is an effective and safe treatment for narcolepsy

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449314

Comparison of clinical characteristics among narcolepsy with and without cataplexy and idiopathic hypersomnia without long sleep time, focusing on HLA-DRB1( *)1501/DQB1( *)0602 finding.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449314

Glycinergic and GABA(A)-mediated inhibition of somatic motoneurons does not mediate rapid eye movement sleep motor atonia.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449314

Hypocretin (orexin) loss and sleep disturbances in Parkinson's Disease.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449314

Hypocretin (orexin) cell loss in Parkinson's disease.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449314

Narcolepsy-cataplexy associated with precocious puberty.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449314

Narp immunostaining of human hypocretin (orexin) neurons: loss in narcolepsy

28 November 2018

1 reference

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Modafinil: a novel stimulant for the treatment of narcolepsy.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449314

Medications for the treatment of narcolepsy

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449314

Dopaminergic-adrenergic interactions in the wake promoting mechanism of modafinil

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449314

Modafinil more effectively induces wakefulness in orexin-null mice than in wild-type littermates

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449314

A pilot study on the effects of sodium oxybate on sleep architecture and daytime alertness in narcolepsy

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449314

The clinical spectrum of narcolepsy with cataplexy: a reappraisal.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449314

Hypocretinergic control of spinal cord motoneurons.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449314

Cataplexy-active neurons in the hypothalamus: implications for the role of histamine in sleep and waking behavior

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449314

Effects of IV and ICV hypocretin-1 (orexin A) in hypocretin receptor-2 gene mutated narcoleptic dogs and IV hypocretin-1 replacement therapy in a hypocretin-ligand-deficient narcoleptic dog.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449314

Report of a case of immunosuppression with prednisone in an 8-year-old boy with an acute onset of hypocretin-deficiency narcolepsy

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449314

Localization of the GABAergic and non-GABAergic neurons projecting to the sublaterodorsal nucleus and potentially gating paradoxical sleep onset.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449314

Excitatory effects of hypocretin-1 (orexin-A) in the trigeminal motor nucleus are reversed by NMDA antagonism

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449314

Changes in inhibitory amino acid release linked to pontine-induced atonia: an in vivo microdialysis study.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449314

Hypocretin/Orexin excites hypocretin neurons via a local glutamate neuron-A potential mechanism for orchestrating the hypothalamic arousal system

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449314

The rat ponto-medullary network responsible for paradoxical sleep onset and maintenance: a combined microinjection and functional neuroanatomical study

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449314

Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449314

Implication of dopaminergic mechanisms in the wake-promoting effects of amphetamine: a study of D- and L-derivatives in canine narcolepsy.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449314

Hypocretin (orexin) activation and synaptic innervation of the locus coeruleus noradrenergic system.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449314

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449314

Locus coeruleus neurons: cessation of activity during cataplexy.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449314

Effects of methylphenidate on extracellular dopamine, serotonin, and norepinephrine: comparison with amphetamine

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449314

Comparative effects of modafinil and amphetamine on daytime sleepiness and cataplexy of narcoleptic dogs

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449314

Circadian rhythms in narcolepsy: studies on a 90 minute day.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449314

Canine model of narcolepsy: genetic and developmental determinants.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449314

Letter: Animal model of narcolepsy-cataplexy

28 November 2018

1 reference

12 December 2020

Successful management of cataplexy with intravenous immunoglobulins at narcolepsy onset

1 reference

12 December 2020

Hypocretin (orexin) loss in Parkinson's disease.

1 reference

12 December 2020

Narcolepsy in seven dogs

1 reference

12 December 2020

10.1523/JNEUROSCI.2630-12.2012

Identifiers

DOI

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22956821%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22956821%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22956821%20AND%20SRC:MED&resulttype=core&format=json