Pathophysiology of childhood polycystic kidney diseases: new insights into disease-specific therapy (Q27000075)

Ellis D. Avner

series ordinal

2

1 reference

language of work or name

1 reference

January 2014

1 reference

1 January 2014

7 references

22 April 2019

24 June 2019

9 October 2019

29 May 2020

19 July 2020

28 September 2020

18 November 2020

8 references

22 April 2019

24 June 2019

9 October 2019

29 May 2020

19 July 2020

28 September 2020

18 November 2020

75

1 reference

issue

1-2

1 reference

page(s)

148-57

1 reference

Cardiovascular abnormalities in autosomal-dominant polycystic kidney disease

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953890

PKHD1 gene silencing may cause cell abnormal proliferation through modulation of intracellular calcium in autosomal recessive polycystic kidney disease

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953890

The gene mutated in autosomal recessive polycystic kidney disease encodes a large, receptor-like protein

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953890

Polycystin-2 is an intracellular calcium release channel

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953890

Homo- and heterodimeric interactions between the gene products of PKD1 and PKD2

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953890

PKD1 interacts with PKD2 through a probable coiled-coil domain

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953890

PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953890

Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953890

Activation of the MEK5/ERK5 cascade is responsible for biliary dysgenesis in a rat model of Caroli's disease

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953890

New approaches to the autosomal recessive polycystic kidney disease patient with dual kidney-liver complications

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953890

TRPV4 dysfunction promotes renal cystogenesis in autosomal recessive polycystic kidney disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953890

Characteristics of congenital hepatic fibrosis in a large cohort of patients with autosomal recessive polycystic kidney disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953890

Calmodulin-sensitive adenylyl cyclases mediate AVP-dependent cAMP production and Cl- secretion by human autosomal dominant polycystic kidney cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953890

Endogenous concentrations of ouabain act as a cofactor to stimulate fluid secretion and cyst growth of in vitro ADPKD models via cAMP and EGFR-Src-MEK pathways

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953890

The fetal environment: a critical phase that determines future renal outcomes in autosomal dominant polycystic kidney disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953890

Function of transient receptor potential cation channel subfamily V member 4 (TRPV4) as a mechanical transducer in flow-sensitive segments of renal collecting duct system

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953890

Role of microRNAs in kidney homeostasis and disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953890

Fluid transport and cystogenesis in autosomal dominant polycystic kidney disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953890

Cyclic AMP-mediated cyst expansion

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953890

Diagnosis and management of childhood polycystic kidney disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953890

Epidermal growth factor-mediated proliferation and sodium transport in normal and PKD epithelial cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953890

Birth of a healthy infant following preimplantation PKHD1 haplotyping for autosomal recessive polycystic kidney disease using multiple displacement amplification

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953890

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953890

Polycystic kidney disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953890

Increased left ventricular mass in children with autosomal dominant polycystic kidney disease and borderline hypertension

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953890

TRPP2 and TRPV4 form a polymodal sensory channel complex

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953890

Src inhibition ameliorates polycystic kidney disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953890

Dual role of the TRPV4 channel as a sensor of flow and osmolality in renal epithelial cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953890

Polycystic kidney disease: genes, proteins, animal models, disease mechanisms and therapeutic opportunities

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953890

Molecular pathogenesis of ADPKD: the polycystin complex gets complex

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953890

Transforming growth factor alpha (TGF-alpha) and other targets of tumor necrosis factor-alpha converting enzyme (TACE) in murine polycystic kidney disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953890

Abnormal EGF-dependent regulation of sodium absorption in ARPKD collecting duct cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953890

Cyclic AMP promotes growth and secretion in human polycystic kidney epithelial cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953890

Calcium restriction allows cAMP activation of the B-Raf/ERK pathway, switching cells to a cAMP-dependent growth-stimulated phenotype

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953890

Molecular genetics of autosomal recessive polycystic kidney disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953890

A polycystin-1 multiprotein complex is disrupted in polycystic kidney disease cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953890

Bending the primary cilium opens Ca2+-sensitive intermediate-conductance K+ channels in MDCK cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953890

PKHD1, the polycystic kidney and hepatic disease 1 gene, encodes a novel large protein containing multiple immunoglobulin-like plexin-transcription-factor domains and parallel beta-helix 1 repeats

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953890

Epidermal growth factor receptor activity mediates renal cyst formation in polycystic kidney disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953890

Candidate gene associated with a mutation causing recessive polycystic kidney disease in mice.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953890

Cystic maldevelopment of the kidney

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953890

Polycystic kidney diseases in childhood

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953890

Biliary epithelial cells from mice with congenital polycystic kidney disease are hyperresponsive to epidermal growth factor

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953890

Epidermal growth factor (EGF) expression in the congenital polycystic mouse kidney.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953890

Renal volume in children with ADPKD: size matters

31 May 2018

1 reference

https://api.crossref.org/works/10.1038%2FPR.2013.191

Incompletely penetrant PKD1 alleles suggest a role for gene dosage in cyst initiation in polycystic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FPR.2013.191

Autosomal recessive polycystic kidney disease: long-term outcome of neonatal survivors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FPR.2013.191

Kidney and liver transplantation in patients with autosomal recessive polycystic kidney disease: a multicentric study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FPR.2013.191

Combined liver-kidney transplantation for children with autosomal recessive polycystic kidney disease (ARPKD): indication and outcome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FPR.2013.191

Clinical and molecular characterization defines a broadened spectrum of autosomal recessive polycystic kidney disease (ARPKD).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FPR.2013.191

Polycystic kidney disease: The complete structure of the PKD1 gene and its protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FPR.2013.191

Cellular and subcellular localization of the ARPKD protein; fibrocystin is expressed on primary cilia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FPR.2013.191

Mechanism-based therapeutics for autosomal dominant polycystic kidney disease: recent progress and future prospects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FPR.2013.191

Combination treatment of PKD utilizing dual inhibition of EGF-receptor activity and ligand bioavailability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FPR.2013.191

The mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FPR.2013.191

Effect of flow and stretch on the [Ca2+]i response of principal and intercalated cells in cortical collecting duct

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FPR.2013.191

Electrolyte and fluid secretion by cultured human inner medullary collecting duct cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FPR.2013.191

Cyclic AMP activates B-Raf and ERK in cyst epithelial cells from autosomal-dominant polycystic kidneys

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FPR.2013.191

Na transport in autosomal recessive polycystic kidney disease (ARPKD) cyst lining epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FPR.2013.191

Role of CFTR in autosomal recessive polycystic kidney disease.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953890

Transforming growth factor alpha and epidermal growth factor expression in experimental murine polycystic kidney disease.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953890

Early renal abnormalities in children with postnatally diagnosed autosomal dominant polycystic kidney disease

28 November 2018

1 reference

https://api.crossref.org/works/10.1038%2FPR.2013.191

Lowering of Pkd1 expression is sufficient to cause polycystic kidney disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FPR.2013.191

An autopsy case of clinically un-diagnosed autosomal recessive polycystic kidney disease in 77-year-old male

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FPR.2013.191

Cyst number but not the rate of cystic growth is associated with the mutated gene in autosomal dominant polycystic kidney disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FPR.2013.191

Polycystic kidney disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FPR.2013.191

Abnormal polarization of EGF receptors and autocrine stimulation of cyst epithelial growth in human ADPKD

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FPR.2013.191

Treatment of polycystic kidney disease with a novel tyrosine kinase inhibitor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FPR.2013.191

Cyst fluid composition in human autosomal recessive polycystic kidney disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FPR.2013.191

Epithelial transport in polycystic kidney disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FPR.2013.191

cAMP stimulates the in vitro proliferation of renal cyst epithelial cells by activating the extracellular signal-regulated kinase pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FPR.2013.191

Calcium restores a normal proliferation phenotype in human polycystic kidney disease epithelial cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FPR.2013.191

Cyst formation and growth in autosomal dominant polycystic kidney disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FPR.2013.191

The secretion of fluid by renal cysts from patients with autosomal dominant polycystic kidney disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FPR.2013.191

Defective epithelial chloride transport in a gene-targeted mouse model of cystic fibrosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FPR.2013.191

PGD for autosomal dominant polycystic kidney disease type 1

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FPR.2013.191

Functional activity of epidermal growth factor receptors in autosomal recessive polycystic kidney disease

31 March 2020

1 reference

https://pubmed.ncbi.nlm.nih.gov/24336431

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Cyst fluid from human autosomal dominant polycystic kidneys promotes cyst formation and expansion by renal epithelial cells in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/24336431

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/PR.2013.191

1 reference

Dimensions Publication ID

1397256

1034126881

0 references

1397256

1 reference

1 reference

1 reference