IL-1 Receptor-Associated Kinase Signaling and Its Role in Inflammation, Cancer Progression, and Therapy Resistance (Q26866390)

Sabina Kaczanowska

series ordinal

2

1 reference

Eduardo Davila

series ordinal

3

1 reference

language of work or name

1 reference

2014

1 reference

published in

Frontiers in Immunology

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volume

5

1 reference

page(s)

553

1 reference

IRAK-M mediates Toll-like receptor/IL-1R-induced NFκB activation and cytokine production

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miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice

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Hallmarks of Cancer: The Next Generation

21 March 2017

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Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and toll-like receptor-mediated NF-kappaB activation

21 March 2017

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Tumor cells deactivate human monocytes by up-regulating IL-1 receptor associated kinase-M expression via CD44 and TLR4

21 March 2017

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Human lung cancer cells express functionally active Toll-like receptor 9

21 March 2017

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IRAK-M is a negative regulator of Toll-like receptor signaling

21 March 2017

1 reference

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IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase

21 March 2017

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IRAK1b, a novel alternative splice variant of interleukin-1 receptor-associated kinase (IRAK), mediates interleukin-1 signaling and has prolonged stability

21 March 2017

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IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family

21 March 2017

1 reference

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Pyogenic bacterial infections in humans with IRAK-4 deficiency

21 March 2017

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Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4

21 March 2017

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Augmentation of therapeutic responses in melanoma by inhibition of IRAK-1,-4

21 March 2017

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Oncogenically active MYD88 mutations in human lymphoma

21 March 2017

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miR-146a suppresses invasion of pancreatic cancer cells

21 March 2017

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IRAK-4 inhibitors for inflammation

21 March 2017

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Increased toll-like receptor 9 expression in cervical neoplasia

21 March 2017

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High mobility group box 1 protein interacts with multiple Toll-like receptors

21 March 2017

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MicroRNA pathways in flies and worms: growth, death, fat, stress, and timing

21 March 2017

1 reference

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Targeting IRAK1 as a therapeutic approach for myelodysplastic syndrome

7 April 2017

1 reference

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Ginsenosides are novel naturally-occurring aryl hydrocarbon receptor ligands

28 September 2017

1 reference

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MYD88 L265P mutation in Waldenstrom macroglobulinemia.

28 September 2017

1 reference

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TLR agonists: our best frenemy in cancer immunotherapy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233944

Helicobacter pylori induces increased expression of Toll-like receptors and decreased Toll-interacting protein in gastric mucosa that persists throughout gastric carcinogenesis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233944

Endogenous IRAK-M attenuates postinfarction remodeling through effects on macrophages and fibroblasts.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233944

Effects of (5Z)-7-oxozeaenol on MDA-MB-231 breast cancer cells.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233944

Differentiation and gene expression profile of tumor-associated macrophages

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233944

Modulation of pancreatic cancer chemoresistance by inhibition of TAK1

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233944

Role of IL-1 receptor-associated kinase-M (IRAK-M) in priming of immune and inflammatory responses by nitrogen bisphosphonates

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233944

Tumor-produced, active interleukin-1β regulates gene expression in carcinoma-associated fibroblasts.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233944

Induction of TLR-2 and TLR-5 expression by Helicobacter pylori switches cagPAI-dependent signalling leading to the secretion of IL-8 and TNF-α.

28 September 2017

1 reference

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TGF-β-induced IRAK-M expression in tumor-associated macrophages regulates lung tumor growth

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233944

The dual functions of IL-1 receptor-associated kinase 2 in TLR9-mediated IFN and proinflammatory cytokine production

28 September 2017

1 reference

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1,3,5-trihydroxy-4-prenylxanthone represses lipopolysaccharide-induced iNOS expression via impeding posttranslational modification of IRAK-1.

28 September 2017

1 reference

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Toll-like receptor signaling pathways--therapeutic opportunities

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233944

TLR-signaling networks: an integration of adaptor molecules, kinases, and cross-talk.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233944

Differential regulation of interleukin-1 receptor-associated kinase-1 (IRAK-1) and IRAK-2 by microRNA-146a and NF-kappaB in stressed human astroglial cells and in Alzheimer disease.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233944

The interleukin-1 receptor-associated kinases: critical regulators of innate immune signalling.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233944

Expression of interleukin-1 receptor-associated kinase-1 in non-small cell lung carcinoma and preneoplastic lesions

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233944

Selective up-regulation of CDK2 is critical for TLR9 signaling stimulated proliferation of human lung cancer cell

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233944

TLR9 signaling promotes tumor progression of human lung cancer cell in vivo

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233944

Targeting protein kinases for the development of anti-inflammatory drugs

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233944

Breast cancer metastasis suppressor 1 up-regulates miR-146, which suppresses breast cancer metastasis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233944

The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233944

Expression of microRNA-146 suppresses NF-kappaB activity with reduction of metastatic potential in breast cancer cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233944

Insights from vaccinia virus into Toll-like receptor signalling proteins and their regulation by ubiquitin: role of IRAK-2.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233944

IRAK1: a critical signaling mediator of innate immunity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233944

HMGB1 signals through toll-like receptor (TLR) 4 and TLR2.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233944

A novel splice variant of interleukin-1 receptor (IL-1R)-associated kinase 1 plays a negative regulatory role in Toll/IL-1R-induced inflammatory signaling.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233944

The human Burkitt lymphoma cell line Namalwa represents a homogenous cell system characterized by high levels of Toll-like receptor 9 and activation by CpG oligonucleotides

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233944

Identification and cloning of genes displaying elevated expression as a consequence of metastatic progression in human melanoma cells by rapid subtraction hybridization

28 September 2017

1 reference

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Sequential autophosphorylation steps in the interleukin-1 receptor-associated kinase-1 regulate its availability as an adapter in interleukin-1 signaling

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233944

Characterization of interleukin-1 receptor-associated kinase in normal and endotoxin-tolerant cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233944

Ginsenoside Re ameliorates inflammation by inhibiting the binding of lipopolysaccharide to TLR4 on macrophages

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233944

IL-1 receptor-associated kinase modulates host responsiveness to endotoxin.

31 May 2018

1 reference

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Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2.

21 January 2018

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https://api.crossref.org/works/10.3389%2FFIMMU.2014.00553

Toll-like receptor-9 expression is inversely correlated with estrogen receptor status in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2014.00553

Ginsenoside Rb1 and its metabolite compound K inhibit IRAK-1 activation--the key step of inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2014.00553

Expression of toll-like receptor-9 is increased in poorly differentiated prostate tumors

21 January 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/25452754

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The interleukin-1 receptor-associated kinase is degraded by proteasomes following its phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/25452754

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Impaired antigen presentation and potent phagocytic activity identifying tumor-tolerant human monocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/25452754

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.3389/FIMMU.2014.00553

1 reference

3620805

3620805

1 reference

1 reference

1 reference