Proteoglycans in the central nervous system: role in development, neural repair, and Alzheimer's disease (Q26865932)

Craig Freeman

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2

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Glenn A. Jacobson

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3

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David H. Small

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4

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language of work or name

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February 2013

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65

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PubMed

issue

2

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PubMed

page(s)

108-20

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Isolation and characterization of human heparin

PubMed

cites work

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Sulfate content and specific glycosaminoglycan backbone of perlecan are critical for perlecan's enhancement of islet amyloid polypeptide (amylin) fibril formation

21 January 2018

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Roles of mast cells and basophils in innate and acquired immunity

21 January 2018

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Regulated diversity of heparan sulfate

21 January 2018

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Biosynthesis of chondroitin/dermatan sulfate

21 January 2018

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Hyaluronan: genetic insights into the complex biology of a simple polysaccharide

21 January 2018

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MINI REVIEW Keratan sulfate: structure, biosynthesis, and function

21 January 2018

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Lecticans: organizers of the brain extracellular matrix

21 January 2018

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The role of chondroitin sulfate proteoglycans in regeneration and plasticity in the central nervous system

21 January 2018

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Phosphacan, a chondroitin sulfate proteoglycan of brain that interacts with neurons and neural cell-adhesion molecules, is an extracellular variant of a receptor-type protein tyrosine phosphatase

21 January 2018

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Leucine-rich repeat glycoproteins of the extracellular matrix.

21 January 2018

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The primary structure of NG2, a novel membrane-spanning proteoglycan

21 January 2018

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A novel repeat in the melanoma-associated chondroitin sulfate proteoglycan defines a new protein family

21 January 2018

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Neuroglycan C, a Novel Membrane-spanning Chondroitin Sulfate Proteoglycan That Is Restricted to the Brain

21 January 2018

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Genomic organization and expression pattern of mouse neuroglycan C in the cerebellar development

21 January 2018

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The Alzheimer amyloid precursor proteoglycan (appican) is present in brain and is produced by astrocytes but not by neurons in primary neural cultures.

21 January 2018

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The chondroitin sulfate attachment site of appican is formed by splicing out exon 15 of the amyloid precursor gene

21 January 2018

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Heparan sulfate proteoglycans: structure, protein interactions and cell signaling

21 January 2018

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Biology of the syndecans: a family of transmembrane heparan sulfate proteoglycans

21 January 2018

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Syndecan 3 intramembrane proteolysis is presenilin/gamma-secretase-dependent and modulates cytosolic signaling

21 January 2018

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Shedding of syndecan-1 and -4 ectodomains is regulated by multiple signaling pathways and mediated by a TIMP-3-sensitive metalloproteinase

21 January 2018

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21 January 2018

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Developmental roles of the glypicans

21 January 2018

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Processing by proprotein convertases is required for glypican-3 modulation of cell survival, Wnt signaling, and gastrulation movements

21 January 2018

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The biology of perlecan: the multifaceted heparan sulphate proteoglycan of basement membranes and pericellular matrices

21 January 2018

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Multifunctionality of extracellular and cell surface heparan sulfate proteoglycans

21 January 2018

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Agrin is a chimeric proteoglycan with the attachment sites for heparan sulfate/chondroitin sulfate located in two multiple serine-glycine clusters

21 January 2018

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Basement membrane proteoglycans: from cellar to ceiling

21 January 2018

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Testican, a multidomain testicular proteoglycan resembling modulators of cell social behaviour

21 January 2018

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Functions of chondroitin sulfate and heparan sulfate in the developing brain

21 January 2018

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Role of the extracellular matrix during neural crest cell migration

21 January 2018

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Expression pattern of collagen IX and potential role in the segmentation of the peripheral nervous system

21 January 2018

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Sulfated proteoglycans in astroglial barriers inhibit neurite outgrowth in vitro

21 January 2018

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Chondroitin-4-sulfation negatively regulates axonal guidance and growth

21 January 2018

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Identification and functions of chondroitin sulfate in the milieu of neural stem cells.

21 January 2018

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Brevican in the developing hippocampal fimbria: differential expression in myelinating oligodendrocytes and adult astrocytes suggests a dual role for brevican in central nervous system fiber tract development

21 January 2018

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Brevican distinctively assembles extracellular components at the large diameter nodes of Ranvier in the CNS

21 January 2018

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21 January 2018

Sugar codes for axons?

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A role for proteoglycans in the guidance of a subset of pioneer axons in cultured embryos of the cockroach.

21 January 2018

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Neurite outgrowth activity of protease nexin-1 on neuroblastoma cells requires thrombin inhibition

21 January 2018

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A monoclonal antibody against a laminin-heparan sulfate proteoglycan complex perturbs cranial neural crest migration in vivo

21 January 2018

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Interactions between basic fibroblast growth factor (FGF) and glycosoaminoglycans in promoting neurite outgrowth

21 January 2018

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Axon sorting in the optic tract requires HSPG synthesis by ext2 (dackel) and extl3 (boxer).

21 January 2018

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Syndecan regulates cell migration and axon guidance in C. elegans

21 January 2018

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Molecular characterization and expression of heparan-sulfate 6-sulfotransferase. Complete cDNA cloning in human and partial cloning in Chinese hamster ovary cells

21 January 2018

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An animal cell mutant defective in heparan sulfate hexuronic acid 2-O-sulfation

21 January 2018

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Heparan sulphation patterns generated by specific heparan sulfotransferase enzymes direct distinct aspects of retinal axon guidance at the optic chiasm.

21 January 2018

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Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein

21 January 2018

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Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members

21 January 2018

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Characterization of an amyloid beta precursor protein that binds heparin and contains tyrosine sulfate

21 January 2018

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The regulation of amyloid beta protein precursor secretion and its modulatory role in cell adhesion

21 January 2018

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Expression and analysis of heparin-binding regions of the amyloid precursor protein of Alzheimer's disease.

21 January 2018

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Secreted glypican binds to the amyloid precursor protein of Alzheimer's disease (APP) and inhibits APP-induced neurite outgrowth.

21 January 2018

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Localisation of specific heparan sulfate proteoglycans during the proliferative phase of brain development.

21 January 2018

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Specific modification of heparan sulphate is required for normal cerebral cortical development

21 January 2018

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Identification of agrin, a synaptic organizing protein from Torpedo electric organ

21 January 2018

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Agrin-like molecules at synaptic sites in normal, denervated, and damaged skeletal muscles

21 January 2018

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The juxtamembrane region of MuSK has a critical role in agrin-mediated signaling

21 January 2018

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Agrin plays an organizing role in the formation of sympathetic synapses

21 January 2018

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Synapse loss in cortex of agrin-deficient mice after genetic rescue of perinatal death.

21 January 2018

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Progesterone-induced agrin expression in astrocytes modulates glia-neuron interactions leading to synapse formation.

21 January 2018

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Syndecan-2 induces filopodia and dendritic spine formation via the neurofibromin-PKA-Ena/VASP pathway

21 January 2018

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Critical periods during sensory development

21 January 2018

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Composition of perineuronal net extracellular matrix in rat brain: a different disaccharide composition for the net-associated proteoglycans

21 January 2018

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The perineuronal net and the control of CNS plasticity

21 January 2018

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Reactivation of ocular dominance plasticity in the adult visual cortex.

21 January 2018

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Sensory deprivation alters aggrecan and perineuronal net expression in the mouse barrel cortex.

21 January 2018

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Modification of extracellular matrix by enzymatic removal of chondroitin sulfate and by lack of tenascin-R differentially affects several forms of synaptic plasticity in the hippocampus

21 January 2018

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Neurocan is dispensable for brain development

21 January 2018

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Brevican-deficient mice display impaired hippocampal CA1 long-term potentiation but show no obvious deficits in learning and memory

21 January 2018

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The bright side of the glial scar in CNS repair

21 January 2018

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Chondroitin sulphate proteoglycans: inhibitory components of the glial scar

21 January 2018

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Traumatic brain injury results in disparate regions of chondroitin sulfate proteoglycan expression that are temporally limited

21 January 2018

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Chondroitinase ABC promotes functional recovery after spinal cord injury

21 January 2018

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Relationship between sprouting axons, proteoglycans and glial cells following unilateral nigrostriatal axotomy in the adult rat.

21 January 2018

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Increased syndecan expression by pleiotrophin and FGF receptor-expressing astrocytes in injured brain tissue.

21 January 2018

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Expression pattern of glypican-1 mRNA after brain injury in mice.

21 January 2018

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Heparan sulphate proteoglycans in glia and in the normal and injured CNS: expression of sulphotransferases and changes in sulphation

21 January 2018

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Intracellular trafficking in neurones and glia of fibroblast growth factor-2, fibroblast growth factor receptor 1 and heparan sulphate proteoglycans in the injured adult rat cerebral cortex.

21 January 2018

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N-acetylglucosamine 6-O-sulfotransferase-1-deficient mice show better functional recovery after spinal cord injury.

21 January 2018

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Global prevalence of dementia: a Delphi consensus study

21 January 2018

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ALZHEIMER'S DISEASE--AN ELECTRON MICROSCOPICAL STUDY

21 January 2018

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Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

21 January 2018

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Amyloid plaque core protein in Alzheimer disease and Down syndrome

21 January 2018

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The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

21 January 2018

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

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Amyloid beta-peptide is produced by cultured cells during normal metabolism

21 January 2018

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Localization of heparan sulfate glycosaminoglycan and proteoglycan core protein in aged brain and Alzheimer's disease

21 January 2018

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Microangiopathy and the colocalization of heparan sulfate proteoglycan with amyloid in senile plaques of Alzheimer's disease

21 January 2018

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Agrin is a major heparan sulfate proteoglycan accumulating in Alzheimer's disease brain.

21 January 2018

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Agrin binds to beta-amyloid (Abeta), accelerates abeta fibril formation, and is localized to Abeta deposits in Alzheimer's disease brain

21 January 2018

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Chondroitin sulfate proteoglycans are associated with the lesions of Alzheimer's disease

21 January 2018

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Peripheral distribution of dermatan sulfate proteoglycans (decorin) in amyloid-containing plaques and their presence in neurofibrillary tangles of Alzheimer's disease

21 January 2018

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Heparan sulfate proteoglycan expression in cerebrovascular amyloid beta deposits in Alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis (Dutch) brains.

21 January 2018

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Interaction between beta-amyloid protein and heparan sulfate proteoglycans from the cerebral capillary basement membrane in Alzheimer's disease.

21 January 2018

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Localization of perlecan (or a perlecan-related macromolecule) to isolated microglia in vitro and to microglia/macrophages following infusion of beta-amyloid protein into rodent hippocampus

21 January 2018

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Binding of secreted human neuroblastoma proteoglycans to the Alzheimer's amyloid A4 peptide.

21 January 2018

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Effects of sulfate ions on Alzheimer beta/A4 peptide assemblies: implications for amyloid fibril-proteoglycan interactions

21 January 2018

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The sulfate moieties of glycosaminoglycans are critical for the enhancement of beta-amyloid protein fibril formation

21 January 2018

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Amyloid-beta interactions with chondroitin sulfate-derived monosaccharides and disaccharides. implications for drug development

21 January 2018

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Sulfated polysaccharides promote the assembly of amyloid beta(1-42) peptide into stable fibrils of reduced cytotoxicity

21 January 2018

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Proteoglycan-mediated inhibition of A beta proteolysis. A potential cause of senile plaque accumulation.

21 January 2018

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Amyloid beta protein (A beta) removal by neuroglial cells in culture

21 January 2018

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Alzheimer's disease: Tau proteins, the promoting factors of microtubule assembly, are major components of paired helical filaments.

21 January 2018

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Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans.

21 January 2018

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Alzheimer-like changes in microtubule-associated protein Tau induced by sulfated glycosaminoglycans. Inhibition of microtubule binding, stimulation of phosphorylation, and filament assembly depend on the degree of sulfation.

21 January 2018

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Sulfo-glycosaminoglycan content affects PHF-tau solubility and allows the identification of different types of PHFs.

21 January 2018

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Heparin-induced conformational change in microtubule-associated protein Tau as detected by chemical cross-linking and phosphopeptide mapping

21 January 2018

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Heparin promotes beta-secretase cleavage of the Alzheimer's amyloid precursor protein

21 January 2018

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Heparan sulfate regulates amyloid precursor protein processing by BACE1, the Alzheimer's beta-secretase

21 January 2018

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Novel heparan sulphate analogues: inhibition of beta-secretase cleavage of amyloid precursor protein.

21 January 2018

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Heparin activates beta-secretase (BACE1) of Alzheimer's disease and increases autocatalysis of the enzyme.

21 January 2018

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Glycosaminoglycan-induced activation of the beta-secretase (BACE1) of Alzheimer's disease

21 January 2018

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Effects of heparin and enoxaparin on APP processing and Aβ production in primary cortical neurons from Tg2576 mice.

21 January 2018

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Size and sulfation are critical for the effect of heparin on APP processing and Aβ production

21 January 2018

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Neuroprotective properties of glycosaminoglycans: potential treatment for neurodegenerative disorders

21 January 2018

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The blood-brain barrier accessibility of a heparin-derived oligosaccharides C3.

21 January 2018

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Protective effect of the heparin-derived oligosaccharide C3, on AF64A-induced cholinergic lesion in rats

21 January 2018

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Glycosaminoglycan C3 protects against AF64A-induced cholinotoxicity in a dose-dependent and time-dependent manner

21 January 2018

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Arresting amyloidosis in vivo using small-molecule anionic sulphonates or sulphates: implications for Alzheimer's disease

21 January 2018

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Low molecular weight glycosaminoglycan blockade of beta-amyloid induced neuropathology

21 January 2018

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Peripheral treatment with enoxaparin, a low molecular weight heparin, reduces plaques and beta-amyloid accumulation in a mouse model of Alzheimer's disease.

21 January 2018

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Enoxaparin treatment administered at both early and late stages of amyloid β deposition improves cognition of APPswe/PS1dE9 mice with differential effects on brain Aβ levels

21 January 2018

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Heparin attenuates cytotoxic and inflammatory activity of Alzheimer amyloid-beta in vitro.

21 January 2018

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Heparan sulfate mediates amyloid-beta internalization and cytotoxicity

21 January 2018

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Heparan sulphate proteoglycan and the low-density lipoprotein receptor-related protein 1 constitute major pathways for neuronal amyloid-beta uptake

21 January 2018

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