Simple sugar intake and hepatocellular carcinoma: epidemiological and mechanistic insight (Q26864513)

main subject

hepatocellular carcinoma

1 reference

metabolic dysfunction–associated steatotic liver disease

18 November 2019

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18 November 2019

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18 November 2019

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18 November 2019

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4 February 2021

1 reference

18 November 2019

Núria Roglans

3

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Marta Alegret

object named as

Marta Alegret

series ordinal

2

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Juan C. Laguna

object named as

Juan Laguna

series ordinal

1

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language of work or name

1 reference

22 December 2014

15 references

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18 November 2019

4 February 2021

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28 November 2023

15 references

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3 April 2019

20 August 2019

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4 February 2021

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6

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page(s)

5933-54

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issue

12

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Creative Commons Attribution

copyright license

14 references

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on focus list of Wikimedia project

ScienceSource

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cites work

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21 March 2017

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21 March 2017

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21 March 2017

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21 March 2017

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21 March 2017

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21 March 2017

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Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

21 March 2017

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Autophagy regulates lipid metabolism

21 March 2017

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Steatohepatitis: a tale of two "hits"?

7 April 2017

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Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression

7 April 2017

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Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production

7 April 2017

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Body-mass index and risk of 22 specific cancers: a population-based cohort study of 5·24 million UK adults

7 April 2017

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The expression of beclin-1, an autophagic gene, in hepatocellular carcinoma associated with clinical pathological and prognostic significance

28 September 2017

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Development of hepatocellular carcinoma in a murine model of nonalcoholic steatohepatitis induced by use of a high-fat/fructose diet and sedentary lifestyle

28 September 2017

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Obesity-associated mechanisms of hepatocarcinogenesis

28 September 2017

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Sweetened carbonated beverage consumption and cancer risk: meta-analysis and review

28 September 2017

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Sugars and risk of mortality in the NIH-AARP Diet and Health Study

28 September 2017

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Liquid fructose down-regulates liver insulin receptor substrate 2 and gluconeogenic enzymes by modifying nutrient sensing factors in rats

28 September 2017

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The association between metabolic syndrome and hepatocellular carcinoma: systemic review and meta-analysis

28 September 2017

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Diabetes mellitus is associated with hepatocellular carcinoma: a retrospective case-control study in hepatitis endemic area

28 September 2017

1 reference

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Dietary fructose enhances the incidence of precancerous hepatocytes induced by administration of diethylnitrosamine in rat

28 September 2017

1 reference

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NAFLD, NASH and liver cancer

28 September 2017

1 reference

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Diabetes mellitus, insulin treatment, diabetes duration, and risk of biliary tract cancer and hepatocellular carcinoma in a European cohort

28 September 2017

1 reference

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Synergistic effects of family history of hepatocellular carcinoma and hepatitis B virus infection on risk for incident hepatocellular carcinoma.

28 September 2017

1 reference

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Hyperglycemia is a significant prognostic factor of hepatocellular carcinoma after curative therapy

28 September 2017

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Way back for fructose and liver metabolism: bench side to molecular insights

28 September 2017

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Insulin resistance and cancer: the role of insulin and IGFs

28 September 2017

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Metabolic syndrome and hepatocellular carcinoma risk

28 September 2017

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The Warburg effect: insights from the past decade

28 September 2017

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Glycemic index, glycemic load, dietary carbohydrate, and dietary fiber intake and risk of liver and biliary tract cancers in Western Europeans

28 September 2017

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Consumption of artificial sweetener- and sugar-containing soda and risk of lymphoma and leukemia in men and women

28 September 2017

1 reference

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Effect of pioglitazone on the fructose-induced abdominal adipose tissue dysfunction

28 September 2017

1 reference

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Female mice are more susceptible to nonalcoholic fatty liver disease: sex-specific regulation of the hepatic AMP-activated protein kinase-plasminogen activator inhibitor 1 cascade, but not the hepatic endotoxin response

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4277008

Fructose consumption and cancer: is there a connection?

28 September 2017

1 reference

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HbA1C and cancer risk in patients with type 2 diabetes--a nationwide population-based prospective cohort study in Sweden

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4277008

Dietary fructose, carbohydrates, glycemic indices and pancreatic cancer risk: a systematic review and meta-analysis of cohort studies

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4277008

The insulin and insulin-like growth factor receptor family in neoplasia: an update

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4277008

HCC and NASH: how strong is the clinical demonstration?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4277008

Sucrose-sweetened beverages increase fat storage in the liver, muscle, and visceral fat depot: a 6-mo randomized intervention study

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4277008

Coffee, tea, and sugar-sweetened carbonated soft drink intake and pancreatic cancer risk: a pooled analysis of 14 cohort studies

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4277008

The role of fructose-enriched diets in mechanisms of nonalcoholic fatty liver disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4277008

Hepatocellular carcinoma in non-alcoholic steatohepatitis: Growing evidence of an epidemic?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4277008

Refined fructose and cancer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4277008

Diabetes mellitus, fasting glucose, and risk of cause-specific death

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4277008

Sugars in diet and risk of cancer in the NIH-AARP Diet and Health Study

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4277008

mTOR couples cellular nutrient sensing to organismal metabolic homeostasis

28 September 2017

1 reference

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Increased lipogenesis, induced by AKT-mTORC1-RPS6 signaling, promotes development of human hepatocellular carcinoma.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4277008

Soft drinks, sweetened beverages and risk of pancreatic cancer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4277008

Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer.

28 September 2017

1 reference

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Metformin: taking away the candy for cancer?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4277008

High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4277008

Risk of cancer in a large cohort of U.S. veterans with diabetes.

28 September 2017

1 reference

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Risk of colon cancer and coffee, tea, and sugar-sweetened soft drink intake: pooled analysis of prospective cohort studies

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4277008

Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4277008

Curcumin inhibits hepatic protein-tyrosine phosphatase 1B and prevents hypertriglyceridemia and hepatic steatosis in fructose-fed rats

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4277008

Soft drink and juice consumption and risk of pancreatic cancer: the Singapore Chinese Health Study

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4277008

Nonalcoholic fatty liver disease: a review and update

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4277008

Effect of miRNA-10b in regulating cellular steatosis level by targeting PPAR-alpha expression, a novel mechanism for the pathogenesis of NAFLD.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4277008

Glycemic index, carbohydrates, glycemic load, and the risk of pancreatic cancer in a prospective cohort study

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4277008

Mammalian target of rapamycin complex 1 (mTORC1) signaling in energy balance and obesity.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4277008

Sweets, sweetened beverages, and risk of pancreatic cancer in a large population-based case-control study

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4277008

Nonalcoholic steatohepatitis induced by a high-fat diet promotes diethylnitrosamine-initiated early hepatocarcinogenesis in rats

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4277008

Oxidative and nitrosative stress and fibrogenic response

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4277008

Suppressor of cytokine signaling-3 (SOCS-3) and a deficit of serine/threonine (Ser/Thr) phosphoproteins involved in leptin transduction mediate the effect of fructose on rat liver lipid metabolism

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4277008

Prediagnostic body-mass index, plasma C-peptide concentration, and prostate cancer-specific mortality in men with prostate cancer: a long-term survival analysis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4277008

Phosphorylation of IRS proteins, insulin action, and insulin resistance

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4277008

Added sugar and sugar-sweetened foods and beverages and the risk of pancreatic cancer in the National Institutes of Health-AARP Diet and Health Study

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4277008

Hepatic NF-kappa B essential modulator deficiency prevents obesity-induced insulin resistance but synergizes with high-fat feeding in tumorigenesis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4277008

The role of autophagy in cancer development and response to therapy.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4277008

Dietary fructose: implications for dysregulation of energy homeostasis and lipid/carbohydrate metabolism

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4277008

Nutritional regulation of the insulin-like growth factors

28 September 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4277008

28 September 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4277008

Dietary sugars and lipid metabolism in humans

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4277008

mTOR in viral hepatitis and hepatocellular carcinoma: function and treatment

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4277008

SIRT1 regulates oncogenesis via a mutant p53-dependent pathway in hepatocellular carcinoma

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4277008

Attenuation of insulin resistance, metabolic syndrome and hepatic oxidative stress by resveratrol in fructose-fed rats

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4277008

Reduction of liver fructokinase expression and improved hepatic inflammation and metabolism in liquid fructose-fed rats after atorvastatin treatment

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4277008

Fructose and carbonyl metabolites as endogenous toxins

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4277008

Enhancement of hepatocarcinogenesis in rats by dietary fructose

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4277008

Behavioral and Dietary Risk Factors for Noncommunicable Diseases

31 May 2018

1 reference

mTORC1 activity as a determinant of cancer risk--rationalizing the cancer-preventive effects of adiponectin, metformin, rapamycin, and low-protein vegan diets.

21 January 2018

1 reference

Metabolic risk factors and primary liver cancer in a prospective study of 578,700 adults

21 January 2018

1 reference

Hepatocellular carcinoma in Japanese patients with nonalcoholic fatty liver disease, alcoholic liver disease, and chronic liver disease of unknown etiology: report of the nationwide survey.

21 January 2018

1 reference

Metabolic factors and risk of hepatocellular carcinoma by chronic hepatitis B/C infection: a follow-up study in Taiwan.

21 January 2018

1 reference

Glycemic load in relation to hepatocellular carcinoma among patients with chronic hepatitis infection

21 January 2018

1 reference

Dietary glycemic load and hepatocellular carcinoma with or without chronic hepatitis infection

21 January 2018

1 reference

Dietary intakes of carbohydrates in relation to prostate cancer risk: a prospective study in the Malmö Diet and Cancer cohort

21 January 2018

1 reference

Dietary patterns as predictors of prostate cancer in Jamaican men.

21 January 2018

1 reference

Sugar-sweetened soft drink consumption and risk of pancreatic cancer in two prospective cohorts

21 January 2018

1 reference

Diet and premenopausal bilateral breast cancer: a case-control study

21 January 2018

1 reference

Impairment of hepatic Stat-3 activation and reduction of PPARalpha activity in fructose-fed rats

21 January 2018

1 reference

Liver AMP/ATP ratio and fructokinase expression are related to gender differences in AMPK activity and glucose intolerance in rats ingesting liquid fructose.

21 January 2018

1 reference

Liquid fructose downregulates Sirt1 expression and activity and impairs the oxidation of fatty acids in rat and human liver cells.

21 January 2018

1 reference

Fructose overconsumption causes dyslipidemia and ectopic lipid deposition in healthy subjects with and without a family history of type 2 diabetes.

21 January 2018

1 reference

Effects of short-term overfeeding with fructose, fat and fructose plus fat on plasma and hepatic lipids in healthy men.

21 January 2018

1 reference

Antibiotics protect against fructose-induced hepatic lipid accumulation in mice: role of endotoxin

21 January 2018

1 reference

Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice.

21 January 2018

1 reference

Fructose-induced steatosis in mice: role of plasminogen activator inhibitor-1, microsomal triglyceride transfer protein and NKT cells.

21 January 2018

1 reference

mTOR and P70 S6 kinase expression in primary liver neoplasms

21 January 2018

1 reference

The mTOR pathway is associated with the poor prognosis of human hepatocellular carcinoma

21 January 2018

1 reference

Adipose tissue remodeling in rats exhibiting fructose-induced obesity.

21 January 2018

1 reference

Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation

21 January 2018

1 reference

Excessive superoxide anion generation plays a key role in carcinogenesis.

21 January 2018

1 reference

21 January 2018

1 reference

Associations between dietary and lifestyle risk factors and colorectal cancer in the Scottish population

21 January 2018

1 reference

Fructose supplementation impairs rat liver autophagy through mTORC activation without inducing endoplasmic reticulum stress.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4277008

Consumption of sugar and sugar-sweetened foods and the risk of pancreatic cancer in a prospective study

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4277008

Impaired very low-density lipoprotein-triglyceride catabolism in acute and chronic fructose-fed rats

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4277008

Partial characterization of the fructose-induced defect in very-low-density lipoprotein triglyceride metabolism

28 November 2018

1 reference

12 December 2020

Tissue-specific regulation of inflammation by macrophage migration inhibitory factor and glucocorticoids in fructose-fed Wistar rats

1 reference

12 December 2020

Fructose triggers DNA modification and damage in an Escherichia coli plasmid

1 reference

12 December 2020

Toll-like receptors 1-9 are elevated in livers with fructose-induced hepatic steatosis

1 reference

12 December 2020

Rats fed fructose-enriched diets have characteristics of nonalcoholic hepatic steatosis

1 reference

12 December 2020

Role of the inducible nitric oxide synthase in the onset of fructose-induced steatosis in mice

1 reference

12 December 2020

Identifiers

DOI

10.3390/NU6125933

1 reference

release_gevv3cpwknelva674xol3nxqwy

967021

Fatcat ID

0 references

967021

1 reference

1 reference

1 reference