Neuroprotection for stroke: current status and future perspectives (Q26853031)

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16 February 2020

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26 January 2021

Neuroprotection for stroke: current status and future perspectives (English)

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16 February 2020

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15 August 2020

therapeutic hypothermia

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15 August 2020

neuroprotective agent

1 reference

26 January 2021

2

1 reference

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16 February 2020

Alastair Buchan

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3

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16 February 2020

Christoph Kleinschnitz

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4

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16 February 2020

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Jens Minnerup

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18 September 2012

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16 February 2020

15 August 2020

26 January 2021

International Journal of Molecular Sciences

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22 March 2019

25 April 2019

17 June 2019

25 June 2019

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16 February 2020

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9

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16 February 2020

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Delayed administration of interleukin-1 receptor antagonist reduces ischemic brain damage and inflammation in comorbid rats

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Magnesium for aneurysmal subarachnoid haemorrhage (MASH-2): a randomised placebo-controlled trial

28 September 2017

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The 1027th target candidate in stroke: Will NADPH oxidase hold up?

28 September 2017

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Roles of individual prolyl-4-hydroxylase isoforms in the first 24 hours following transient focal cerebral ischaemia: insights from genetically modified mice

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Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation

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Efficacy of minocycline in acute ischemic stroke: a single-blinded, placebo-controlled trial

28 September 2017

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Neuroprotection for ischaemic stroke: translation from the bench to the bedside

28 September 2017

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α(2)-adrenoceptors do not mediate neuroprotection in acute ischemic stroke in mice

28 September 2017

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28 September 2017

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28 September 2017

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Preclinical drug evaluation for combination therapy in acute stroke using systematic review, meta-analysis, and subsequent experimental testing

28 September 2017

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28 September 2017

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Can molecular and cellular neuroprotection be translated into therapies for patients?: yes, but not the way we tried it before

28 September 2017

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Intravenous thrombolysis plus hypothermia for acute treatment of ischemic stroke (ICTuS-L): final results

28 September 2017

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Minocycline to improve neurologic outcome in stroke (MINOS): a dose-finding study

28 September 2017

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Functional assessments in the rodent stroke model

28 September 2017

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EPO for stroke therapy - Is there a future for further clinical development?

28 September 2017

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Pharmacological therapy in Parkinson's disease: focus on neuroprotection

28 September 2017

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Rapid brain penetration of interleukin-1 receptor antagonist in rat cerebral ischaemia: pharmacokinetics, distribution, protection

28 September 2017

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Intracarotid administration of human bone marrow mononuclear cells in rat photothrombotic ischemia

28 September 2017

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A systematic review and meta-analysis of erythropoietin in experimental stroke

28 September 2017

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Recombinant human erythropoietin in the treatment of acute ischemic stroke

28 September 2017

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Granulocyte-colony stimulating factor in experimental stroke and its effects on infarct size and functional outcome: A systematic review

28 September 2017

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Prolyl hydroxylase domain inhibitors: a route to HIF activation and neuroprotection

28 September 2017

1 reference

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Implications of vascular endothelial growth factor for postischemic neurovascular remodeling.

28 September 2017

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High-dose lovastatin for acute ischemic stroke: results of the phase I dose escalation neuroprotection with statin therapy for acute recovery trial (NeuSTART)

28 September 2017

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Systematic review and stratified meta-analysis of the efficacy of interleukin-1 receptor antagonist in animal models of stroke

28 September 2017

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The efficacy of erythropoietin and its analogues in animal stroke models: a meta-analysis

28 September 2017

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Metabolic downregulation: a key to successful neuroprotection?

28 September 2017

1 reference

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Evidence for the efficacy of NXY-059 in experimental focal cerebral ischaemia is confounded by study quality

28 September 2017

1 reference

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Minocycline treatment in acute stroke: an open-label, evaluator-blinded study.

28 September 2017

1 reference

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Acute ischemic stroke: overview of major experimental rodent models, pathophysiology, and therapy of focal cerebral ischemia.

28 September 2017

1 reference

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Statins: multiple mechanisms of action in the ischemic brain

28 September 2017

1 reference

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Hypothermia in animal models of acute ischaemic stroke: a systematic review and meta-analysis

28 September 2017

1 reference

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A critical appraisal of the NXY-059 neuroprotection studies for acute stroke: a need for more rigorous testing of neuroprotective agents in animal models of stroke

28 September 2017

1 reference

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Induced hypothermia for acute stroke

28 September 2017

1 reference

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Novel isoforms of NADPH-oxidase in cerebral vascular control.

28 September 2017

1 reference

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Hypoxia-inducible factor prolyl 4-hydroxylase inhibition. A target for neuroprotection in the central nervous system

28 September 2017

1 reference

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A randomised phase II study of interleukin-1 receptor antagonist in acute stroke patients

28 September 2017

1 reference

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Neuroprotective effect of simvastatin in stroke: a comparison between adult and neonatal rat models of cerebral ischemia.

28 September 2017

1 reference

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Reactive oxygen species and the modulation of stroke.

28 September 2017

1 reference

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Neuroprotection for ischemic stroke: two decades of success and failure

28 September 2017

1 reference

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Targeting eNOS for stroke protection

28 September 2017

1 reference

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Nitrones as neuroprotective agents in cerebral ischemia, with particular reference to NXY-059.

28 September 2017

1 reference

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Erythropoietin selectively attenuates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosis

28 September 2017

1 reference

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Stroke-induced immunodeficiency promotes spontaneous bacterial infections and is mediated by sympathetic activation reversal by poststroke T helper cell type 1-like immunostimulation

28 September 2017

1 reference

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Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury?

28 September 2017

1 reference

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Interleukin-1 and neuronal injury: mechanisms, modification, and therapeutic potential

28 September 2017

1 reference

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Neuroprotective agents for the treatment of acute ischemic stroke

28 September 2017

1 reference

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Erythropoietin therapy for acute stroke is both safe and beneficial

28 September 2017

1 reference

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Effects of hypothermia on excitatory amino acids and metabolism in stroke patients: a microdialysis study

28 September 2017

1 reference

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The Clomethiazole Acute Stroke Study in tissue-type plasminogen activator-treated stroke (CLASS-T): final results

28 September 2017

1 reference

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Feasibility and safety of moderate hypothermia after massive hemispheric infarction

28 September 2017

1 reference

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Cooling for acute ischemic brain damage (cool aid): an open pilot study of induced hypothermia in acute ischemic stroke

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472773

Reactive oxygen radicals in signaling and damage in the ischemic brain

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472773

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472773

Role of oxidative stress in cardiovascular diseases

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472773

Recommendations for standards regarding preclinical neuroprotective and restorative drug development

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472773

Role of oxidants in ischemic brain damage

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472773

Glutamate release and free radical production following brain injury: effects of posttraumatic hypothermia

28 September 2017

1 reference

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The molecular control of hematopoiesis: From clonal development in culture to therapy in the clinic

28 September 2017

1 reference

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Treatment of cerebral ischemia by disrupting ischemia-induced interaction of nNOS with PSD-95.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472773

Neuroprotection by dimethyloxalylglycine following permanent and transient focal cerebral ischemia in rats.

31 May 2018

1 reference

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DP-b99, a membrane-activated metal ion chelator, as neuroprotective therapy in ischemic stroke

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472773

Meta-analysis of the efficacy of granulocyte-colony stimulating factor in animal models of focal cerebral ischemia

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472773

The ALIAS Pilot Trial: a dose-escalation and safety study of albumin therapy for acute ischemic stroke--I: Physiological responses and safety results

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472773

The ALIAS Pilot Trial: a dose-escalation and safety study of albumin therapy for acute ischemic stroke--II: neurologic outcome and efficacy analysis.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472773

Exacerbation of ischemic brain damage by localized striatal injection of interleukin-1beta in the rat.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472773

Neuroprotection afforded by a combination of eliprodil and a thrombolytic agent, rt-PA, in a rat thromboembolic stroke model.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472773

Free radicals in cerebral ischemia.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472773

Cooling for Acute Ischemic Brain Damage (COOL AID): a feasibility trial of endovascular cooling

31 May 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS130911753

Ebselen attenuates oxidative DNA damage and enhances its repair activity in the thalamus after focal cortical infarction in hypertensive rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS130911753

Neuroprotection of ebselen against ischemia/reperfusion injury involves GABA shunt enzymes.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS130911753

Ebselen in acute middle cerebral artery occlusion: a placebo-controlled, double-blind clinical trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS130911753

Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction. Randomized, placebo-controlled, double-blind study at multicenters

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS130911753

Prehospital neuroprotective therapy for acute stroke: results of the Field Administration of Stroke Therapy-Magnesium (FAST-MAG) pilot trial

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS130911753

Human albumin therapy of acute ischemic stroke: marked neuroprotective efficacy at moderate doses and with a broad therapeutic window.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS130911753

Functional and histological evidence for the protective effect of NXY-059 in a primate model of stroke when given 4 hours after occlusion

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS130911753

NXY-059 for the treatment of acute stroke: pooled analysis of the SAINT I and II Trials

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS130911753

NXY-059: brain or vessel protection.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS130911753

Methodological quality of animal studies of neuroprotective agents currently in phase II/III acute ischemic stroke trials

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS130911753

Cosmic implications of NXY-059.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS130911753

Granulocyte colony-stimulating factor protects the brain against experimental stroke via inhibition of apoptosis and inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS130911753

Treatment of stroke with erythropoietin enhances neurogenesis and angiogenesis and improves neurological function in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS130911753

Granulocyte colony-stimulating factor enhances angiogenesis after focal cerebral ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS130911753

AXIS: a trial of intravenous granulocyte colony-stimulating factor in acute ischemic stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS130911753

Mechanisms of action of neuroprotectants in stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS130911753

REPRINT: International, multicenter randomized preclinical trials in translational stroke research: it is time to act.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS130911753

Neuroprotective effects of the spin trap agent disodium-[(tert-butylimino)methyl]benzene-1,3-disulfonate N-oxide (generic NXY-059) in a rabbit small clot embolic stroke model: combination studies with the thrombolytic tissue plasminogen activator

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS130911753

Involvement of matrix metalloproteinase in thrombolysis-associated hemorrhagic transformation after embolic focal ischemia in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS130911753

Combination Therapy Stroke Trial: recombinant tissue-type plasminogen activator with/without lubeluzole

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS130911753

Treatment of ischemic brain damage by perturbing NMDA receptor- PSD-95 protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS130911753

Specific targeting of pro-death NMDA receptor signals with differing reliance on the NR2B PDZ ligand

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS130911753

Stroke: Disruption of the nNOS–PSD-95 complex is neuroprotective in models of cerebral ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS130911753

Treatment of stroke with a PSD-95 inhibitor in the gyrencephalic primate brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS130911753

Neuron-specific inactivation of the hypoxia inducible factor 1 alpha increases brain injury in a mouse model of transient focal cerebral ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS130911753

Delayed administration of interleukin-1 receptor antagonist protects against transient cerebral ischaemia in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS130911753

Interleukin-1 receptor antagonist penetrates human brain at experimentally therapeutic concentrations.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS130911753

Interleukin-1 receptor antagonist reverses stroke-associated peripheral immune suppression.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS130911753

Erythropoietin and erythropoietin receptor in human ischemic/hypoxic brain.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472773

Albumin modulation of capillary permeability: role of endothelial cell [Ca2+]i.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472773

Primate work faces German veto

28 November 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS130911753

NXY-059 for the treatment of acute ischemic stroke

21 January 2018

1 reference

12 December 2020

Thresholds in cerebral ischemia - the ischemic penumbra

1 reference

12 December 2020

Reduction of tissue plasminogen activator-induced hemorrhage and brain injury by free radical spin trapping after embolic focal cerebral ischemia in rats

1 reference

12 December 2020

To serve and neuroprotect

1 reference

12 December 2020

Neuroprotective effects of ebselen following forebrain ischemia: involvement of glutamate and nitric oxide

1 reference

12 December 2020

Therapeutic hypothermia for acute stroke

1 reference

12 December 2020

The Membrane-Activated Chelator Stroke Intervention (MACSI) Trial of DP-b99 in acute ischemic stroke: a randomized, double-blind, placebo-controlled, multinational pivotal phase III study

1 reference

12 December 2020

Identifiers

DOI

10.3390/IJMS130911753

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23109881%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23109881%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23109881%20AND%20SRC:MED&resulttype=core&format=json