The multidrug transporter P-glycoprotein in pharmacoresistance to antiepileptic drugs (Q26824649)

main subject

multiple drug resistance

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author

Stanisław Jerzy Czuczwar

series ordinal

4

object named as

Czuczwar SJ

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Stępień KM

1

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Tomaszewski M

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2

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Tomaszewska J

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3

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language of work or name

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2012

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published in

Pharmacological Reports

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volume

64

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issue

5

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page(s)

1011-9

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Exposure to antiepileptic drugs does not alter the functionality of P-glycoprotein in brain capillary endothelial and kidney cell lines.

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Localization of breast cancer resistance protein (BCRP) in microvessel endothelium of human control and epileptic brain

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Valproic acid is not a substrate for P-glycoprotein or multidrug resistance proteins 1 and 2 in a number of in vitro and in vivo transport assays.

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7 January 2021

Differences in the transport of the antiepileptic drugs phenytoin, levetiracetam and carbamazepine by human and mouse P-glycoprotein

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7 January 2021

A novel positron emission tomography imaging protocol identifies seizure-induced regional overactivity of P-glycoprotein at the blood-brain barrier

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7 January 2021

The influence of C3435T polymorphism of ABCB1 gene on penetration of phenobarbital across the blood-brain barrier in patients with generalized epilepsy

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Polymorphism of the MDR1/ABCB1 C3435T drug-transporter and resistance to anticonvulsant drugs: a meta-analysis

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Patients' experiences of injury as a result of epilepsy.

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Phosphorylation by protein kinase C and cyclic AMP-dependent protein kinase of synthetic peptides derived from the linker region of human P-glycoprotein

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7 January 2021

Lack of interactions between breast cancer resistance protein (bcrp/abcg2) and selected antiepileptic agents.

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7 January 2021

Therapeutic drug monitoring and clinical outcomes in epileptic Egyptian patients: a gene polymorphism perspective study

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7 January 2021

Pharmacoresistance: modern concept and basic data derived from human brain tissue

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7 January 2021

Epileptic seizures caused by low valproic acid levels from an interaction with meropenem

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7 January 2021

Identification of the in vivo phosphorylation sites for acidic-directed kinases in murine mdr1b P-glycoprotein.

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7 January 2021

C3435T polymorphism in the MDR1 gene affects the enterocyte expression level of CYP3A4 rather than Pgp in recipients of living-donor liver transplantation

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7 January 2021

Genetic analysis of the multidrug transporter

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The molecular basis of multidrug resistance in cancer: the early years of P-glycoprotein research

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7 January 2021

ABCB1 C3435T polymorphism and the risk of resistance to antiepileptic drugs in epilepsy: a systematic review and meta-analysis

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7 January 2021

Very important pharmacogene summary: ABCB1 (MDR1, P-glycoprotein)

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7 January 2021

Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

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7 January 2021

Nimodipine restores the altered hippocampal phenytoin pharmacokinetics in a refractory epileptic model.

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7 January 2021

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

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7 January 2021

Lack of association between ABCB1, ABCG2, and ABCC2 genetic polymorphisms and multidrug resistance in partial epilepsy

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7 January 2021

Expression of adenosine triphosphate-binding cassette (ABC) drug transporters in peripheral blood cells: relevance for physiology and pharmacotherapy

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7 January 2021

Adenosine triphosphate-binding cassette transporters mediate chemokine (C-C motif) ligand 2 secretion from reactive astrocytes: relevance to multiple sclerosis pathogenesis

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7 January 2021

Functional test of multidrug transporter activity in hippocampal-neocortical brain slices from epileptic patients

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7 January 2021

Potential role of drug transporters in the pathogenesis of medically intractable epilepsy

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7 January 2021

Drug-resistant epilepsy

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7 January 2021

Basic mechanisms of antiepileptic drugs and their pharmacokinetic/pharmacodynamic interactions: an update

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7 January 2021

Potential role of multidrug resistant proteins in refractory epilepsy and antiepileptic drugs interactions

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7 January 2021

ABC transporters during epilepsy and mechanisms underlying multidrug resistance in refractory epilepsy

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7 January 2021

Mitochondrial superoxide production in kainate-induced hippocampal damage.

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7 January 2021

The clinical impact of pharmacogenetics on the treatment of epilepsy

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7 January 2021

Imaging of P-glycoprotein function and expression to elucidate mechanisms of pharmacoresistance in epilepsy

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7 January 2021

Do ATP-binding cassette transporters cause pharmacoresistance in epilepsy? Problems and approaches in determining which antiepileptic drugs are affected

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7 January 2021

Drug resistance in brain diseases and the role of drug efflux transporters.

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7 January 2021

Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases

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7 January 2021

Role of multidrug transporters in pharmacoresistance to antiepileptic drugs

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7 January 2021

Evaluation of transport of common antiepileptic drugs by human multidrug resistance-associated proteins (MRP1, 2 and 5) that are overexpressed in pharmacoresistant epilepsy

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7 January 2021

Several major antiepileptic drugs are substrates for human P-glycoprotein

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7 January 2021

The effect of carbapenem antibiotics on plasma concentrations of valproic acid

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7 January 2021

Effects of ABCB1 polymorphisms on plasma carbamazepine concentrations and pharmacoresistance in Chinese patients with epilepsy.

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7 January 2021

Modulation of P-glycoprotein at the blood-brain barrier: opportunities to improve central nervous system pharmacotherapy

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7 January 2021

Antiepileptic drugs modulate P-glycoproteins in the brain: a mice study with (11)C-desmethylloperamide.

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7 January 2021

Association of ABCB1 genetic variants 3435C>T and 2677G>T to ABCB1 mRNA and protein expression in brain tissue from refractory epilepsy patients.

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7 January 2021

Expression and immunolocalization of the multidrug resistance proteins, MRP1-MRP6 (ABCC1-ABCC6), in human brain

1 reference

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7 January 2021

Predisposition to epilepsy--does the ABCB1 gene play a role?

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7 January 2021

Association of MDR1 (C3435T) polymorphism and resistance to carbamazepine in epileptic patients from Turkey

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7 January 2021

ABCG2: structure, function and role in drug response

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7 January 2021

Modulating P-glycoprotein regulation: future perspectives for pharmacoresistant epilepsies?

1 reference

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7 January 2021

Molecular and cellular mechanisms of pharmacoresistance in epilepsy

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7 January 2021

Why does epilepsy become intractable? Prevention of chronic epilepsy

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7 January 2021

Does P-glycoprotein play a role in pharmacoresistance to antiepileptic drugs?

1 reference

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7 January 2021

Regulation of multidrug resistance protein 1 by tumor necrosis factor alpha in cultured glial cells: involvement of nuclear factor-kappaB and c-Jun N-terminal kinase signaling pathways

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7 January 2021

New developments in antiepileptic drug resistance: an integrative view

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7 January 2021

ABCB1 polymorphisms influence the response to antiepileptic drugs in Japanese epilepsy patients.

1 reference

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7 January 2021

Lack of association between the C3435T polymorphism in the human multidrug resistance (MDR1) gene and response to antiepileptic drug treatment.

1 reference

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7 January 2021

Multidrug-resistance transporters

1 reference

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7 January 2021

Intestinal expression of cytochrome P450 enzymes and ABC transporters and carbamazepine and phenytoin disposition

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7 January 2021

Drug resistance in epilepsy: not futile, but complex?

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7 January 2021

Over-expression of P-glycoprotein in malformations of cortical development.

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7 January 2021

Pharmacogenetics of membrane transporters: an update on current approaches

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7 January 2021

Non-response to antiepileptic pharmacotherapy is associated with the ABCC2 -24C>T polymorphism in young and adult patients with epilepsy.

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7 January 2021

P-glycoprotein activity and biological response.

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7 January 2021

Expression of multidrug transporters MRP1, MRP2, and BCRP shortly after status epilepticus, during the latent period, and in chronic epileptic rats

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7 January 2021

COX-2 inhibition controls P-glycoprotein expression and promotes brain delivery of phenytoin in chronic epileptic rats

1 reference

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7 January 2021

Comparative gene expression profiles of ABC transporters in brain microvessel endothelial cells and brain in five species including human.

1 reference

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7 January 2021

Interaction of antiepileptic drugs with human P-glycoprotein in vitro

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7 January 2021

Increased P-glycoprotein function and level after long-term exposure of four antiepileptic drugs to rat brain microvascular endothelial cells in vitro

1 reference

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7 January 2021

In vitro concentration dependent transport of phenytoin and phenobarbital, but not ethosuximide, by human P-glycoprotein

1 reference

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7 January 2021

The transport of antiepileptic drugs by P-glycoprotein

1 reference

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7 January 2021

In vitro transport profile of carbamazepine, oxcarbazepine, eslicarbazepine acetate, and their active metabolites by human P-glycoprotein

1 reference

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7 January 2021

Regulation of the stability of P-glycoprotein by ubiquitination

1 reference

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7 January 2021