Beyond empiricism: informing vaccine development through innate immunity research (Q26824573)

Crossref

Douglas T. Golenbock

series ordinal

2

1 reference

Crossref

language of work or name

1 reference

16 March 2012

1 reference

1 reference

148

1 reference

page(s)

1284-92

1 reference

issue

6

1 reference

STING is a direct innate immune sensor of cyclic di-GMP

cites work

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Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome

7 April 2017

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Immune signaling by RIG-I-like receptors

7 April 2017

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Development and characterization of synthetic glucopyranosyl lipid adjuvant system as a vaccine adjuvant

7 April 2017

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Future Vaccination Strategies against Tuberculosis: Thinking outside the Box

7 April 2017

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Vaccines with aluminum-containing adjuvants: optimizing vaccine efficacy and thermal stability

7 April 2017

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The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88

7 April 2017

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AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

7 April 2017

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Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

7 April 2017

1 reference

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What led to the Nigerian boycott of the polio vaccination campaign?

7 April 2017

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Adjuvant-enhanced antibody responses in the absence of toll-like receptor signaling

7 April 2017

1 reference

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Lyme disease: Uphill Struggle

7 April 2017

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An alternative and effective HIV vaccination approach based on inhibition of antigen presentation attenuators in dendritic cells

7 April 2017

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Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors

7 April 2017

1 reference

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Rational design of a meningococcal antigen inducing broad protective immunity

7 April 2017

1 reference

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Sipuleucel-T immunotherapy for castration-resistant prostate cancer

7 April 2017

1 reference

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Pathogen recognition and innate immunity

7 April 2017

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Lysine auxotrophy combined with deletion of the SecA2 gene results in a safe and highly immunogenic candidate live attenuated vaccine for tuberculosis

7 April 2017

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The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling

7 April 2017

1 reference

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Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice

7 April 2017

1 reference

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Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans

7 April 2017

1 reference

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Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

7 April 2017

1 reference

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Promiscuous peptide of 16 kDa antigen linked to Pam2Cys protects against Mycobacterium tuberculosis by evoking enduring memory T-cell response

7 April 2017

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The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus.

28 September 2017

1 reference

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Chitosan but not chitin activates the inflammasome by a mechanism dependent upon phagocytosis

28 September 2017

1 reference

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Assessing the safety of adjuvanted vaccines

28 September 2017

1 reference

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Safety and efficacy of the RTS, S/AS01 E candidate malaria vaccine given with expanded-programme-on-immunisation vaccines: 19 month follow-up of a randomised, open-label, phase 2 trial

28 September 2017

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Immunological mechanisms of vaccination

28 September 2017

1 reference

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Induction of Noxa-mediated apoptosis by modified vaccinia virus Ankara depends on viral recognition by cytosolic helicases, leading to IRF-3/IFN-β-dependent induction of pro-apoptotic Noxa.

28 September 2017

1 reference

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Adjuvanticity of the oil-in-water emulsion MF59 is independent of Nlrp3 inflammasome but requires the adaptor protein MyD88

28 September 2017

1 reference

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Salmonella synthesizing 1-dephosphorylated [corrected] lipopolysaccharide exhibits low endotoxic activity while retaining its immunogenicity.

28 September 2017

1 reference

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Regulation of the antimicrobial response by NLR proteins.

28 September 2017

1 reference

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Myeloid C-type lectin receptors in pathogen recognition and host defense

28 September 2017

1 reference

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ISCOMATRIX adjuvant combines immune activation with antigen delivery to dendritic cells in vivo leading to effective cross-priming of CD8+ T cells.

28 September 2017

1 reference

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The safety evaluation of adjuvants during vaccine development: the AS04 experience

28 September 2017

1 reference

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Pathogen-associated molecular patterns on biomaterials: a paradigm for engineering new vaccines

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308125

Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticity

28 September 2017

1 reference

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Microbial manipulation of receptor crosstalk in innate immunity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308125

Programming the magnitude and persistence of antibody responses with innate immunity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308125

Targeted antigen delivery and activation of dendritic cells in vivo: steps towards cost effective vaccines

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308125

Adjuvant System AS03 containing α-tocopherol modulates innate immune response and leads to improved adaptive immunity.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308125

The unexpected link between infection-induced apoptosis and a TH17 immune response.

28 September 2017

1 reference

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Coexpressed RIG-I agonist enhances humoral immune response to influenza virus DNA vaccine

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308125

Flagellin as an adjuvant: cellular mechanisms and potential.

28 September 2017

1 reference

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Reverse vaccinology: developing vaccines in the era of genomics

28 September 2017

1 reference

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Vaccine adjuvants: putting innate immunity to work

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308125

Robust stimulation of humoral and cellular immune responses following vaccination with antigen-loaded beta-glucan particles

28 September 2017

1 reference

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New adjuvants for human vaccines

28 September 2017

1 reference

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Sensing and signaling in antiviral innate immunity

28 September 2017

1 reference

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The potential of 3',5'-cyclic diguanylic acid (c-di-GMP) as an effective vaccine adjuvant

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308125

Cutting edge: Mincle is essential for recognition and adjuvanticity of the mycobacterial cord factor and its synthetic analog trehalose-dibehenate

28 September 2017

1 reference

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Intracellular DNA recognition

28 September 2017

1 reference

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Plasmacytoid dendritic cell-derived type I interferon is crucial for the adjuvant activity of Toll-like receptor 7 agonists

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308125

Polymorphisms in the vitamin A receptor and innate immunity genes influence the antibody response to rubella vaccination

28 September 2017

1 reference

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AS04, an aluminum salt- and TLR4 agonist-based adjuvant system, induces a transient localized innate immune response leading to enhanced adaptive immunity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308125

MF59-adjuvanted versus non-adjuvanted influenza vaccines: integrated analysis from a large safety database.

28 September 2017

1 reference

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Towards an understanding of the adjuvant action of aluminium

28 September 2017

1 reference

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Toll-like receptor ligands synergize through distinct dendritic cell pathways to induce T cell responses: implications for vaccines

28 September 2017

1 reference

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Putting endotoxin to work for us: monophosphoryl lipid A as a safe and effective vaccine adjuvant

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308125

Molecular and cellular signatures of human vaccine adjuvants.

28 September 2017

1 reference

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A20 is an antigen presentation attenuator, and its inhibition overcomes regulatory T cell-mediated suppression

28 September 2017

1 reference

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How do adjuvants work? Important considerations for new generation adjuvants

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308125

Review of hepatitis B surface antigen-1018 ISS adjuvant-containing vaccine safety and efficacy.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308125

Cross-protection against H5N1 influenza virus infection is afforded by intranasal inoculation with seasonal trivalent inactivated influenza vaccine.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308125

The vaccine adjuvant monophosphoryl lipid A as a TRIF-biased agonist of TLR4.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308125

Enhanced humoral and memory B cellular immunity using HPV16/18 L1 VLP vaccine formulated with the MPL/aluminium salt combination (AS04) compared to aluminium salt only

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308125

Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity

28 September 2017

1 reference

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In vivo targeting of antigens to maturing dendritic cells via the DEC-205 receptor improves T cell vaccination

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308125

TLR9 signals after translocating from the ER to CpG DNA in the lysosome

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308125

Vaccine immunity to pathogenic fungi overcomes the requirement for CD4 help in exogenous antigen presentation to CD8+ T cells: implications for vaccine development in immune-deficient hosts

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308125

Generation of a Listeria vaccine strain by enhanced caspase-1 activation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308125

The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1beta secretion but dispensable for adjuvant activity

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308125

Promotion of B cell immune responses via an alum-induced myeloid cell population.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308125

Vaccines for the twenty-first century society.

31 May 2018

1 reference

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First results of phase 3 trial of RTS,S/AS01 malaria vaccine in African children

28 November 2018

1 reference

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DNA released from dying host cells mediates aluminum adjuvant activity

28 November 2018

1 reference

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Induction of a potent immune response in the elderly using the TLR-5 agonist, flagellin, with a recombinant hemagglutinin influenza-flagellin fusion vaccine (VAX125, STF2.HA1 SI).

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308125

Silica Crystals and Aluminum Salts Regulate the Production of Prostaglandin in Macrophages via NALP3 Inflammasome-Independent Mechanisms

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308125

An unexpected role for uric acid as an inducer of T helper 2 cell immunity to inhaled antigens and inflammatory mediator of allergic asthma.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308125

TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308125

Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308125

A model vaccine exploiting fungal mannosylation to increase antigen immunogenicity

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308125

Systemic administration of a TLR7 ligand leads to transient immune incompetence due to peripheral-blood leukocyte depletion.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308125

Dendritic cells internalize vaccine adjuvant after intramuscular injection

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308125

Whole recombinant yeast vaccine activates dendritic cells and elicits protective cell-mediated immunity

28 November 2018

1 reference

12 December 2020

Modulation of the human immune response by the non-toxic and non-pyrogenic adjuvant aluminium hydroxide: effect on antigen uptake and antigen presentation

1 reference

12 December 2020

Toll-dependent selection of microbial antigens for presentation by dendritic cells

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12 December 2020

Neisseria meningitidis PorB, a TLR2 ligand, induces an antigen-specific eosinophil recall response: potential adjuvant for helminth vaccines?

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12 December 2020

Cutting edge: alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome

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12 December 2020

The nonspecific effects of vaccines and the expanded program on immunization

1 reference

12 December 2020

10.1016/J.CELL.2012.02.012

Identifiers

DOI

1 reference

release_rnpl53lnhfeyvol24u4bizjczy

1600214

Fatcat ID

0 references

1600214

1 reference

1 reference

1 reference