Emerging roles for IL-11 signaling in cancer development and progression: Focus on breast cancer (Q26799622)

Cytokine and Growth Factor Reviews

Europe PubMed Central

title

Emerging roles for IL-11 signaling in cancer development and progression: Focus on breast cancer (English)

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Ashwini Chand

2

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Matthias Ernst

object named as

Matthias Ernst

series ordinal

4

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author name string

Cameron N Johnstone

series ordinal

1

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Tracy L Putoczki

series ordinal

3

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language of work or name

English

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publication date

October 2015

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published in

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volume

26

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issue

5

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page(s)

489-98

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cites work

Targeting the interleukin-11 receptor α in metastatic prostate cancer: A first-in-man study

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Expression of murine interleukin 11 and its receptor alpha-chain in adult and embryonic tissues

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Tgf-beta signaling alterations and colon cancer

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Multicenter, randomized study of genetically modified recombinant human interleukin-11 to prevent chemotherapy-induced thrombocytopenia in cancer patients receiving chemotherapy

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

TP53 genomics predict higher clinical and pathologic tumor response in operable early-stage breast cancer treated with docetaxel-capecitabine ± trastuzumab

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Breast cancer metastasis to bone: mechanisms of osteolysis and implications for therapy

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Expression of connective tissue growth factor and interleukin-11 in intratumoral tissue is associated with poor survival after curative resection of hepatocellular carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Bone metastasis from breast cancer involves elevated IL-11 expression and the gp130/STAT3 pathway.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Expression of transcripts of interleukin-6 and related cytokines by human breast tumors, breast cancer cells, and adipose stromal cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Dependency of colorectal cancer on a TGF-β-driven program in stromal cells for metastasis initiation

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

A long noncoding RNA activated by TGF-β promotes the invasion-metastasis cascade in hepatocellular carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

DNA damage-mediated induction of a chemoresistant niche

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Hallmarks of Cancer: The Next Generation

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

The molecular functions of Shp2 in the Ras/Mitogen-activated protein kinase (ERK1/2) pathway

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Transcriptional control of local estrogen formation by aromatase in the breast.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

COX-2 induces IL-11 production in human breast cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Activation of an IL6 inflammatory loop mediates trastuzumab resistance in HER2+ breast cancer by expanding the cancer stem cell population.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Inhibition of IL-6 family cytokines by SOCS3.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

The dynamics of signal triggering in a gp130-receptor complex

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Acquiring signalling specificity from the cytokine receptor gp130.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Interleukins-6 and -11 expression in primary breast cancer and subsequent development of bone metastases

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Production and regulation of interleukin-11 by breast cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

The role of local estrogen biosynthesis in males and females

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Endostatin's antiangiogenic signaling network

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

A multigenic program mediating breast cancer metastasis to bone

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

CLF associates with CLC to form a functional heteromeric ligand for the CNTF receptor complex

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Comprehensive molecular portraits of human breast tumours

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

MicroRNA-30c inhibits human breast tumour chemotherapy resistance by regulating TWF1 and IL-11.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

A role for IL-27p28 as an antagonist of gp130-mediated signaling

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Steps toward mapping the human vasculature by phage display.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Infertility in female mice lacking the receptor for interleukin 11 is due to a defective uterine response to implantation

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Stromal gene expression predicts clinical outcome in breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Microenvironmental regulation of tumor progression and metastasis

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Applying the principles of stem-cell biology to cancer

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Microenvironmental regulation of metastasis

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

STATs in cancer inflammation and immunity: a leading role for STAT3

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Contribution of platelets to tumour metastasis.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

SOCS3-mediated regulation of inflammatory cytokines in PTEN and p53 inactivated triple negative breast cancer model

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Targeting JAK kinase in solid tumors: emerging opportunities and challenges

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Expression and function of members of the cytokine receptor superfamily on breast cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Tumor angiogenesis: therapeutic implications

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Azithromycin for prevention of exacerbations of COPD.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Prospective identification of tumorigenic breast cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Direct and synergistic effects of interleukin 11 on murine hemopoiesis in culture

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophy

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Structural analysis of the gene encoding the murine interleukin-11 receptor alpha-chain and a related locus.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

STAT3 acts as a co-activator of glucocorticoid receptor signaling

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Constitutively active mutant gp130 receptor protein from inflammatory hepatocellular adenoma is inhibited by an anti-gp130 antibody that specifically neutralizes interleukin 11 signaling

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Cytochromes P450 11: expression of the CYP19 (aromatase) gene: an unusual case of alternative promoter usage.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

STAT3 is a potential modulator of HIF-1-mediated VEGF expression in human renal carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Clinical development of recombinant human interleukin-11 to treat chemotherapy-induced thrombocytopenia

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Maternal IL-11Ralpha function is required for normal decidua and fetoplacental development in mice

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

The structure of human interleukin-11 reveals receptor-binding site features and structural differences from interleukin-6

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

High expression of interleukin-11 is an independent indicator of poor prognosis in clear-cell renal cell carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Mitochondrial STAT3 supports Ras-dependent oncogenic transformation.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Gp130 and the interleukin-6 family of cytokines

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Transcriptional regulation of inflammatory mediators secreted by human colonic circular smooth muscle cells.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Combinatorial screenings in patients: the interleukin-11 receptor alpha as a candidate target in the progression of human prostate cancer

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

The tumor suppressor Smad4 is required for transforming growth factor beta-induced epithelial to mesenchymal transition and bone metastasis of breast cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Aromatase localization in human breast cancer tissues: possible interactions between intratumoral stromal and parenchymal cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

The interleukin-11 receptor alpha as a candidate ligand-directed target in osteosarcoma: consistent data from cell lines, orthotopic models, and human tumor samples

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

microRNA-Associated Progression Pathways and Potential Therapeutic Targets Identified by Integrated mRNA and microRNA Expression Profiling in Breast Cancer

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Genetically modified T cells targeting interleukin-11 receptor α-chain kill human osteosarcoma cells and induce the regression of established osteosarcoma lung metastases

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Strong time dependence of the 76-gene prognostic signature for node-negative breast cancer patients in the TRANSBIG multicenter independent validation series

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

In vivo antitumor activity of MEK and phosphatidylinositol 3-kinase inhibitors in basal-like breast cancer models.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Identification of prognosis-relevant subgroups in patients with chemoresistant triple-negative breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Molecular pathways: IL11 as a tumor-promoting cytokine-translational implications for cancers

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Inflammation and increased aromatase expression occur in the breast tissue of obese women with breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Endogenous IL-11 signaling is essential in Th2- and IL-13-induced inflammation and mucus production

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Interleukin-11: a new cytokine critical for osteoclast development

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Autocrine production of IL-11 mediates tumorigenicity in hypoxic cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

JAK inhibitors for myeloproliferative neoplasms: clarifying facts from myths

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Adult Mice With Targeted Mutation of the Interleukin-11 Receptor (IL11Ra) Display Normal Hematopoiesis

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Stat3 enhances transactivation of steroid hormone receptors

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Stat3: linking inflammation to epithelial cancer - more than a "gut" feeling?

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

BreastMark: an integrated approach to mining publicly available transcriptomic datasets relating to breast cancer outcome

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Serial expression analysis of breast tumors during neoadjuvant chemotherapy reveals changes in cell cycle and immune pathways associated with recurrence and response

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

gp130 at the nexus of inflammation, autoimmunity, and cancer

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Expression of interleukin 11 and its receptor and their prognostic value in human breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Triple-negative breast cancer is not a contraindication for breast conservation

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Interleukin-11 drives early lung inflammation during Mycobacterium tuberculosis infection in genetically susceptible mice

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Online survival analysis software to assess the prognostic value of biomarkers using transcriptomic data in non-small-cell lung cancer

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Evaluation of STAT3 signaling in ALDH+ and ALDH+/CD44+/CD24- subpopulations of breast cancer cells.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

IL-6 type cytokine receptor complexes: hexamer, tetramer or both?

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

gp130: a promising drug target for cancer therapy

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

Oncomine 3.0: genes, pathways, and networks in a collection of 18,000 cancer gene expression profiles

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

IL-11 signaling as a therapeutic target for cancer

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

IL-11 activates human endothelial cells to resist immune-mediated injury

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021

IL-6 trans-signaling via the soluble IL-6 receptor: importance for the pro-inflammatory activities of IL-6.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CYTOGFR.2015.07.015

7 January 2021