The role of citicoline in cognitive impairment: pharmacological characteristics, possible advantages, and doubts for an old drug with new perspectives (Q26781186)

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English	The role of citicoline in cognitive impairment: pharmacological characteristics, possible advantages, and doubts for an old drug with new perspectives	scientific article

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scholarly article

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1 reference

2 October 2023

The role of citicoline in cognitive impairment: pharmacological characteristics, possible advantages, and doubts for an old drug with new perspectives (English)

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cognitive disorder

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12 November 2019

CDP-choline (1+)

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12 November 2019

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cognitive dysfunction

object has role

subject heading

object named as

cognitive impairment

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Giovambattista De Sarro

5

object named as

Giovambattista De Sarro

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1

object named as

Pietro Gareri

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Alberto Castagna

2

object named as

Alberto Castagna

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Antonino Maria Cotroneo

3

object named as

Antonino Maria Cotroneo

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Salvatore Putignano

4

object named as

Salvatore Putignano

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Amalia Cecilia Bruni

6

object named as

Amalia Cecilia Bruni

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language of work or name

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publication date

2015

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3 September 2015

4 references

17 September 2019

7 November 2019

12 November 2019

2 October 2023

Clinical Interventions in Aging

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17 September 2019

7 November 2019

12 November 2019

2 October 2023

10

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1421-9

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copyright license

Creative Commons Attribution-NonCommercial

4 references

17 September 2019

7 November 2019

12 November 2019

2 October 2023

SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10.

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Cytidinediphosphocholine (CDP-choline) for cognitive and behavioural disturbances associated with chronic cerebral disorders in the elderly

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Protective effects and mechanisms of sirtuins in the nervous system

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SIRT1 and SIRT2: emerging targets in neurodegeneration

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7 April 2017

Neuroprotective properties of citicoline: facts, doubts and unresolved issues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562749

7 April 2017

Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening

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Evidence for the involvement of TNF and NF-kappaB in hippocampal synaptic plasticity

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7 April 2017

Double-blind placebo-controlled study with citicoline in APOE genotyped Alzheimer's disease patients. Effects on cognitive performance, brain bioelectrical activity and cerebral perfusion

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562749

7 April 2017

Citicoline: pharmacological and clinical review, 2006 update

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562749

7 April 2017

CDP-choline: pharmacological and clinical review

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Sirtuins as possible targets in neurodegenerative diseases

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28 September 2017

Long-term treatment with citicoline may improve poststroke vascular cognitive impairment.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562749

28 September 2017

Effectiveness and safety of citicoline in mild vascular cognitive impairment: the IDEALE study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562749

28 September 2017

Effect of citicoline on functional and cognitive status among patients with traumatic brain injury: Citicoline Brain Injury Treatment Trial (COBRIT).

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562749

28 September 2017

The neurobiology of sirtuins and their role in neurodegeneration

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562749

28 September 2017

Citicoline in the treatment of acute ischaemic stroke: an international, randomised, multicentre, placebo-controlled study (ICTUS trial).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562749

28 September 2017

Retrospective and observational study to assess the efficacy of citicoline in elderly patients suffering from stupor related to complex geriatric syndrome

1 reference

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28 September 2017

SIRT3 gene expression: a link between inherited mitochondrial DNA variants and oxidative stress.

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28 September 2017

SIRT1 protects against α-synuclein aggregation by activating molecular chaperones

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28 September 2017

Citicoline: pharmacological and clinical review, 2010 update.

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28 September 2017

Neuronal Sirt3 protects against excitotoxic injury in mouse cortical neuron culture

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28 September 2017

Neuroprotection and recovery: recent data at the bench on citicoline.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562749

28 September 2017

Citicoline in vascular cognitive impairment and vascular dementia after stroke

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562749

28 September 2017

Citicoline, use in cognitive decline: vascular and degenerative

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562749

28 September 2017

Acetylation of tau inhibits its degradation and contributes to tauopathy

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562749

28 September 2017

Aging and disease: connections to sirtuins

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562749

28 September 2017

Citicoline (Cognizin) in the treatment of cognitive impairment.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562749

28 September 2017

Characterization of a bidirectional promoter shared between two human genes related to aging: SIRT3 and PSMD13.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562749

28 September 2017

Use of the Barthel index and modified Rankin scale in acute stroke trials.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562749

28 September 2017

Reliability and validity of estimating the NIH stroke scale score from medical records

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562749

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Improved reliability of the NIH Stroke Scale using video training. NINDS TPA Stroke Study Group

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28 September 2017

Brain mapping activity and mental performance after chronic treatment with CDP-choline in Alzheimer's disease

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562749

28 September 2017

Citicoline (CDP-choline): mechanisms of action and effects in ischemic brain injury

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562749

28 September 2017

Interobserver agreement for the assessment of handicap in stroke patients.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562749

28 September 2017

Therapeutic effects of CDP-choline in Alzheimer's disease. Cognition, brain mapping, cerebrovascular hemodynamics, and immune factors.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562749

31 May 2018

CDP-choline-induced blood histamine changes in Alzheimer's disease.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562749

31 May 2018

SIRT1 suppresses self-renewal of adult hippocampal neural stem cells.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4562749

28 November 2018

Silent information regulator 1 protects the brain against cerebral ischemic damage

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28 November 2018

Citicoline (CDP-choline) increases Sirtuin1 expression concomitant to neuroprotection in experimental stroke.

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28 November 2018

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28 November 2018

Citicoline inhibits MAP kinase signalling pathways after focal cerebral ischaemia

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28 November 2018

Effect of CDP-choline on cognition and immune function in Alzheimer's disease and multi-infarct dementia.

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28 November 2018

Effects of CDP-choline on cognition and cerebral hemodynamics in patients with Alzheimer's disease.

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28 November 2018

Efficacy and safety of oral CDP-choline. Drug surveillance study in 2817 cases.

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28 November 2018

CDP-choline: repeated oral dose tolerance studies in adult healthy volunteers

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12 December 2020

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