Down syndrome and leukemia: insights into leukemogenesis and translational targets (Q26770335)

Europe PubMed Central

title

Down syndrome and leukemia: insights into leukemogenesis and translational targets (English)

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1 reference

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Marion K Mateos

1

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Draga Barbaric

2

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Sally-Anne Byatt

3

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Rosemary Sutton

4

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Glenn M Marshall

Health Supervision for Children With Down Syndrome

5

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language of work or name

English

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publication date

April 2015

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published in

Translational pediatrics

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volume

4

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issue

2

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page(s)

76-92

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cites work

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GATA1-mutant clones are frequent and often unsuspected in babies with Down syndrome: identification of a population at risk of leukemia

28 September 2017

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Development of acute megakaryoblastic leukemia in Down syndrome is associated with sequential epigenetic changes

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28 September 2017

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28 September 2017

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Perturbation of fetal liver hematopoietic stem and progenitor cell development by trisomy 21

28 September 2017

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28 September 2017

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Transient myeloproliferative disorder in children with Down syndrome: clarity to this enigmatic disorder

28 September 2017

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Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL

28 September 2017

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Exome sequencing identifies GATA1 mutations resulting in Diamond-Blackfan anemia

28 September 2017

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N- and C-terminal transactivation domains of GATA1 protein coordinate hematopoietic program

28 September 2017

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Favorable survival maintained in children who have myeloid leukemia associated with Down syndrome using reduced-dose chemotherapy on Children's Oncology Group trial A2971: a report from the Children's Oncology Group

28 September 2017

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Increased dosage of the chromosome 21 ortholog Dyrk1a promotes megakaryoblastic leukemia in a murine model of Down syndrome.

28 September 2017

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Natural history of transient myeloproliferative disorder clinically diagnosed in Down syndrome neonates: a report from the Children's Oncology Group Study A2971.

28 September 2017

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Trisomic dose of several chromosome 21 genes perturbs haematopoietic stem and progenitor cell differentiation in Down's syndrome

28 September 2017

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miR-125b-2 is a potential oncomiR on human chromosome 21 in megakaryoblastic leukemia

28 September 2017

1 reference

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Perturbed hematopoiesis in the Tc1 mouse model of Down syndrome

28 September 2017

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Down syndrome acute lymphoblastic leukemia, a highly heterogeneous disease in which aberrant expression of CRLF2 is associated with mutated JAK2: a report from the International BFM Study Group

28 September 2017

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Hsa-mir-125b-2 is highly expressed in childhood ETV6/RUNX1 (TEL/AML1) leukemias and confers survival advantage to growth inhibitory signals independent of p53

28 September 2017

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28 September 2017

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28 September 2017

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The key role of stem cell factor/KIT signaling in the proliferation of blast cells from Down syndrome-related leukemia

28 September 2017

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Treatment and prognostic impact of transient leukemia in neonates with Down syndrome

28 September 2017

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Highly penetrant myeloproliferative disease in the Ts65Dn mouse model of Down syndrome

28 September 2017

1 reference

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Identification of distinct molecular phenotypes in acute megakaryoblastic leukemia by gene expression profiling.

28 September 2017

1 reference

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GATA1, cytidine deaminase, and the high cure rate of Down syndrome children with acute megakaryocytic leukemia.

28 September 2017

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Origins of leukaemia in children with Down syndrome

28 September 2017

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28 September 2017

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A pediatric approach to the WHO classification of myelodysplastic and myeloproliferative diseases.

28 September 2017

1 reference

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GATA1 mutations in transient leukemia and acute megakaryoblastic leukemia of Down syndrome

28 September 2017

1 reference

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28 September 2017

1 reference

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28 September 2017

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28 September 2017

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28 September 2017

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Domains of genome-wide gene expression dysregulation in Down's syndrome.

31 May 2018

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28 November 2018

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28 November 2018

1 reference

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Exome sequencing identifies putative drivers of progression of transient myeloproliferative disorder to AMKL in infants with Down syndrome.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4729084

A 15q24 microdeletion in transient myeloproliferative disease (TMD) and acute megakaryoblastic leukaemia (AMKL) implicates PML and SUMO3 in the leukaemogenesis of TMD/AMKL

28 November 2018

1 reference

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28 November 2018

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ERG is a megakaryocytic oncogene.

28 November 2018

1 reference

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Mutations of JAK2 in acute lymphoblastic leukaemias associated with Down's syndrome

28 November 2018

1 reference

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Abnormalities in the myeloid progenitor compartment in Down syndrome fetal liver precede acquisition of GATA1 mutations

28 November 2018

1 reference

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Initiating and cancer-propagating cells in TEL-AML1-associated childhood leukemia.

28 November 2018

1 reference

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Cytogenetic features of acute lymphoblastic and myeloid leukemias in pediatric patients with Down syndrome: an iBFM-SG study

28 November 2018

1 reference

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Hematological abnormalities during the first week of life among neonates with Down syndrome: data from a multihospital healthcare system

28 November 2018

1 reference

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An inherited mutation leading to production of only the short isoform of GATA-1 is associated with impaired erythropoiesis

28 November 2018

1 reference

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A prospective study of the natural history of transient leukemia (TL) in neonates with Down syndrome (DS): Children's Oncology Group (COG) study POG-9481.

28 November 2018

1 reference

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The proto-oncogene ERG in megakaryoblastic leukemias

28 November 2018

1 reference

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Microarray transcript profiling distinguishes the transient from the acute type of megakaryoblastic leukaemia (M7) in Down's syndrome, revealing PRAME as a specific discriminating marker.

28 November 2018

1 reference

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Natural history of GATA1 mutations in Down syndrome

28 November 2018

1 reference

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Acquired mutations in GATA1 in neonates with Down's syndrome with transient myeloid disorder

28 November 2018

1 reference

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Trisomy of Erg is required for myeloproliferation in a mouse model of Down syndrome

28 November 2018

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12 December 2020

Down syndrome and GATA1 mutations in transient abnormal myeloproliferative disorder: mutation classes correlate with progression to myeloid leukemia

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12 December 2020

Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1

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12 December 2020

Myeloid leukemia in children 4 years or older with Down syndrome often lacks GATA1 mutation and cytogenetics and risk of relapse are more akin to sporadic AML

1 reference

12 December 2020

Outcome of Down syndrome associated acute lymphoblastic leukaemia treated on a contemporary protocol

1 reference

12 December 2020

Hematopoietic defects in the Ts1Cje mouse model of Down syndrome

1 reference

12 December 2020

Analysis of GATA1 mutations in Down syndrome transient myeloproliferative disorder and myeloid leukemia

1 reference

12 December 2020

Expression of chromosome 21-localized genes in acute myeloid leukemia: differences between Down syndrome and non-Down syndrome blast cells and relationship to in vitro sensitivity to cytosine arabinoside and daunorubicin

1 reference

12 December 2020

Clonal selection in xenografted TAM recapitulates the evolutionary process of myeloid leukemia in Down syndrome

1 reference

12 December 2020