The urgent need to recover MHC class I in cancers for effective immunotherapy (Q26770165)

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The urgent need to recover MHC class I in cancers for effective immunotherapy (English)

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3 April 2019

8 February 2021

histocompatibility antigens class I

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15 December 2019

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9 September 2020

5

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Angel Garcia-Lora

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4

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Federico Garrido

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author name string

Natalia Aptsiauri

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2

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Elien M Doorduijn

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3

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English

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18 January 2016

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Current Opinion in Immunology

5 March 2020

1 April 2016

2 references

9 September 2020

8 February 2021

6 references

3 April 2019

25 June 2019

15 December 2019

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39

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Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International

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copyright license

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on focus list of Wikimedia project

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ScienceSource

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cites work

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Metastases in immune-mediated dormancy: a new opportunity for targeting cancer

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Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

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A novel category of antigens enabling CTL immunity to tumor escape variants: Cinderella antigens

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Immunology of a Transmissible Cancer Spreading among Tasmanian Devils

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TAP-independent self-peptides enhance T cell recognition of immune-escaped tumors

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Epigenetic modulation with histone deacetylase inhibitors in combination with immunotherapy

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IFNγ producing CD8(+) T cells modified to resist major immune checkpoints induce regression of MHC class I-deficient melanomas

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Generation of MHC class I diversity in primary tumors and selection of the malignant phenotype.

28 September 2017

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Histone deacetylase inhibitor SAHA epigenetically regulates miR-17-92 cluster and MCM7 to upregulate MICA expression in hepatoma.

28 September 2017

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Cytokine therapy reverses NK cell anergy in MHC-deficient tumors

28 September 2017

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Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells

28 September 2017

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Adenovirus expressing β2-microglobulin recovers HLA class I expression and antitumor immunity by increasing T-cell recognition

28 September 2017

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CTLA4 blockade broadens the peripheral T-cell receptor repertoire

28 September 2017

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T lymphocytes restrain spontaneous metastases in permanent dormancy.

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The narrow-spectrum HDAC inhibitor entinostat enhances NKG2D expression without NK cell toxicity, leading to enhanced recognition of cancer cells

28 September 2017

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New role of signal peptide peptidase to liberate C-terminal peptides for MHC class I presentation

28 September 2017

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Immune escape of cancer cells with beta2-microglobulin loss over the course of metastatic melanoma

28 September 2017

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Reversible epigenetic down-regulation of MHC molecules by devil facial tumour disease illustrates immune escape by a contagious cancer

28 September 2017

1 reference

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Cancer heterogeneity: implications for targeted therapeutics

28 September 2017

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Sustained effector function of IL-12/15/18-preactivated NK cells against established tumors.

28 September 2017

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Importance of TAP-independent processing pathways

28 September 2017

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Implication of the β2-microglobulin gene in the generation of tumor escape phenotypes

28 September 2017

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Bladder Cancer Immunotherapy: BCG and Beyond.

28 September 2017

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The tumour suppressor Fhit positively regulates MHC class I expression on cancer cells

28 September 2017

1 reference

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Genome sequencing and analysis of the Tasmanian devil and its transmissible cancer

28 September 2017

1 reference

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Targeting HLA class I expression to increase tumor immunogenicity

28 September 2017

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Novel insights into the molecular mechanisms of HLA class I abnormalities

28 September 2017

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Immunotherapy augments the effect of 5-azacytidine on HPV16-associated tumours with different MHC class I-expression status

28 September 2017

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Regression of melanoma metastases after immunotherapy is associated with activation of antigen presentation and interferon-mediated rejection genes

28 September 2017

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Immunotherapy eradicates metastases with reversible defects in MHC class I expression

28 September 2017

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Strategies to counteract MHC-I defects in tumors

28 September 2017

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Antigen spreading contributes to MAGE vaccination-induced regression of melanoma metastases

28 September 2017

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Immune evasion of microsatellite unstable colorectal cancers

28 September 2017

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"Hard" and "soft" lesions underlying the HLA class I alterations in cancer cells: implications for immunotherapy

28 September 2017

1 reference

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Efficient recovery of HLA class I expression in human tumor cells after beta2-microglobulin gene transfer using adenoviral vector: implications for cancer immunotherapy

28 September 2017

1 reference

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The immunologic constant of rejection

28 September 2017

1 reference

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Late pulmonary metastases of renal cell carcinoma immediately after post-transplantation immunosuppressive treatment: a case report

28 September 2017

1 reference

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Selective cytotoxic T-lymphocyte targeting of tumor immune escape variants

28 September 2017

1 reference

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Analysis of HLA expression in human tumor tissues

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5138279

HLA class I antigen abnormalities and immune escape by malignant cells.

28 September 2017

1 reference

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MHC antigens and tumor escape from immune surveillance

28 September 2017

1 reference

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Multiple genetic alterations cause frequent and heterogeneous human histocompatibility leukocyte antigen class I loss in cervical cancer

28 September 2017

1 reference

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Escape of human solid tumors from T-cell recognition: molecular mechanisms and functional significance.

28 September 2017

1 reference

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Natural history of HLA expression during tumour development.

28 September 2017

1 reference

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Anti-CTLA-4 therapy broadens the melanoma-reactive CD8+ T cell response.

28 September 2017

1 reference

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Epigenetic regulations in the IFNγ signalling pathway: IFNγ-mediated MHC class I upregulation on tumour cells is associated with DNA demethylation of antigen-presenting machinery genes.

31 May 2018

1 reference

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Immunoselection by T lymphocytes generates repeated MHC class I-deficient metastatic tumor variants

31 May 2018

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Implications for immunosurveillance of altered HLA class I phenotypes in human tumours

31 May 2018

1 reference

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Preclinical modeling of EGFR-specific antibody resistance: oncogenic and immune-associated escape mechanisms.

31 May 2018

1 reference

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Downregulation of the activating NKp30 ligand B7-H6 by HDAC inhibitors impairs tumor cell recognition by NK cells

28 November 2018

1 reference

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Immune infiltrates are prognostic factors in localized gastrointestinal stromal tumors

28 November 2018

1 reference

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In situ cytotoxic and memory T cells predict outcome in patients with early-stage colorectal cancer.

28 November 2018

1 reference

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Adaptive immunity maintains occult cancer in an equilibrium state

28 November 2018

1 reference

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Tumor progression can occur despite the induction of very high levels of self/tumor antigen-specific CD8+ T cells in patients with melanoma

28 November 2018

1 reference

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Distribution of HLA class I altered phenotypes in colorectal carcinomas: high frequency of HLA haplotype loss associated with loss of heterozygosity in chromosome region 6p21.

28 November 2018

1 reference

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MHC class I-deficient metastatic tumor variants immunoselected by T lymphocytes originate from the coordinated downregulation of APM components.

28 November 2018

1 reference

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Analysis of HLA class I expression in progressing and regressing metastatic melanoma lesions after immunotherapy

28 November 2018

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12 December 2020

Frequent loss of heterozygosity in the β2-microglobulin region of chromosome 15 in primary human tumors

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12 December 2020

Tumor regressions observed in patients with metastatic melanoma treated with an antigenic peptide encoded by gene MAGE-3 and presented by HLA-A1

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12 December 2020

A progress report on the treatment of 157 patients with advanced cancer using lymphokine-activated killer cells and interleukin-2 or high-dose interleukin-2 alone

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Tumour immunology: MHC antigens and malignancy

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12 December 2020

Intracavitary Bacillus Calmette-Guerin in the treatment of superficial bladder tumors

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12 December 2020

Control of T-cell-mediated immune response by HLA class I in human pancreatic carcinoma

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B7-H abnormalities in melanoma and clinical relevance

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12 December 2020

Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells

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10.1016/J.COI.2015.12.007

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