Programmed cell death protein-1/programmed cell death ligand-1 pathway inhibition and predictive biomarkers: understanding transforming growth factor-beta role (Q26769734)

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English	Programmed cell death protein-1/programmed cell death ligand-1 pathway inhibition and predictive biomarkers: understanding transforming growth factor-beta role	scientific article

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Programmed cell death protein-1/programmed cell death ligand-1 pathway inhibition and predictive biomarkers: understanding transforming growth factor-beta role (English)

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author name string

Mariacarmela Santarpia

1

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María González-Cao

2

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Santiago Viteri

3

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Niki Karachaliou

4

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Giuseppe Altavilla

5

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language of work or name

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publication date

December 2015

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Translational lung cancer research

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4

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6

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728-42

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Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling

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CD28/B7 system of T cell costimulation

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Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

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Epithelial-mesenchymal transitions in tumour progression

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PD-1 and its ligands in tolerance and immunity

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Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion

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CD28 and CTLA-4 coreceptor expression and signal transduction

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TGFbeta in Cancer

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Reversal of the TCR stop signal by CTLA-4

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Smad-dependent and Smad-independent pathways in TGF-beta family signalling

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PD-1 blockade induces responses by inhibiting adaptive immune resistance

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Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2.

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28 September 2017

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28 September 2017

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28 September 2017

Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer

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28 September 2017

Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses

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28 September 2017

Dendritic cells with TGF-beta1 differentiate naive CD4+CD25- T cells into islet-protective Foxp3+ regulatory T cells

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28 September 2017

Mutations of TGFbeta signaling molecules in human disease

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28 September 2017

Regulatory T cells in cancer

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Tissue expression of PD-L1 mediates peripheral T cell tolerance.

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28 September 2017

Alterations in components of the TGF-beta superfamily signaling pathways in human cancer

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28 September 2017

TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance

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SHP-1 and SHP-2 associate with immunoreceptor tyrosine-based switch motif of programmed death 1 upon primary human T cell stimulation, but only receptor ligation prevents T cell activation

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TGF-beta switches from tumor suppressor to prometastatic factor in a model of breast cancer progression.

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28 September 2017

The two faces of transforming growth factor beta in carcinogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4700220

28 September 2017

Stage I non-small cell lung carcinoma: really an early stage?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4700220

28 September 2017

TGF-beta signaling: positive and negative effects on tumorigenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4700220

28 September 2017

Immune-mediated eradication of tumors through the blockade of transforming growth factor-beta signaling in T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4700220

28 September 2017

The CD28 and CTLA-4 receptors associate with the serine/threonine phosphatase PP2A.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4700220

28 September 2017

Liquid biopsies: genotyping circulating tumor DNA

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

Cell-free nucleic acids as biomarkers in cancer patients

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

Circulating tumor DNA as a liquid biopsy for cancer

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

Circulating tumor cells and DNA as liquid biopsies.

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

Circulating tumor cells and circulating tumor DNA.

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

Realizing the potential of plasma genotyping in an age of genotype-directed therapies.

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

Neoplastic characteristics of the DNA found in the plasma of cancer patients

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

Detection of chromosomal alterations in the circulation of cancer patients with whole-genome sequencing

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

Analysis of circulating tumor DNA to monitor metastatic breast cancer

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

Detection of circulating tumor DNA in early- and late-stage human malignancies

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

Development of personalized tumor biomarkers using massively parallel sequencing

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

Detection and quantification of mutations in the plasma of patients with colorectal tumors

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

Circulating mutant DNA to assess tumor dynamics

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

The role of macrophages in the in vitro generation of extracellular DNA from apoptotic and necrotic cells

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

Origin and quantification of circulating DNA in mice with human colorectal cancer xenografts

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

High fragmentation characterizes tumour-derived circulating DNA.

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

Multi-marker analysis of circulating cell-free DNA toward personalized medicine for colorectal cancer

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

About the possible origin and mechanism of circulating DNA apoptosis and active DNA release

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

Quantification of free circulating DNA as a diagnostic marker in lung cancer

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

Plasma DNA quantification in lung cancer computed tomography screening: five-year results of a prospective study.

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

Circulating plasma DNA as diagnostic biomarker in non-small cell lung cancer

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

Circulating DNA is a useful prognostic factor in patients with advanced non-small cell lung cancer.

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

Circulating deoxyribonucleic Acid as prognostic marker in non-small-cell lung cancer patients undergoing chemotherapy.

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

The correlation between cell-free DNA and tumour burden was estimated by PET/CT in patients with advanced NSCLC.

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage.

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

Evaluation of circulating tumor cells and circulating tumor DNA in non-small cell lung cancer: association with clinical endpoints in a phase II clinical trial of pertuzumab and erlotinib

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

Detection of epidermal growth factor receptor mutations in serum as a predictor of the response to gefitinib in patients with non-small-cell lung cancer.

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

Evaluation of epidermal growth factor receptor mutation status in serum DNA as a predictor of response to gefitinib (IRESSA).

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

Detection of epidermal growth factor receptor mutations in plasma by mutant-enriched PCR assay for prediction of the response to gefitinib in patients with non-small-cell lung cancer.

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

Detection of EGFR mutations in plasma DNA from lung cancer patients by mass spectrometry genotyping is predictive of tumor EGFR status and response to EGFR inhibitors

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

EGFR array: uses in the detection of plasma EGFR mutations in non-small cell lung cancer patients

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

Epidermal growth factor receptor mutation status in circulating free DNA in serum: from IPASS, a phase III study of gefitinib or carboplatin/paclitaxel in non-small cell lung cancer.

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

Gefitinib treatment in EGFR mutated caucasian NSCLC: circulating-free tumor DNA as a surrogate for determination of EGFR status

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

Detection of EGFR mutations in plasma and biopsies from non-small cell lung cancer patients by allele-specific PCR assays.

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

Association of EGFR L858R Mutation in Circulating Free DNA With Survival in the EURTAC Trial

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

Single-molecule detection of epidermal growth factor receptor mutations in plasma by microfluidics digital PCR in non-small cell lung cancer patients

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

Insufficiency of peripheral blood as a substitute tissue for detecting EGFR mutations in lung cancer: a meta-analysis.

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

Circulating tumor DNA is effective for the detection of EGFR mutation in non-small cell lung cancer: a meta-analysis

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

Exon 19 deletion mutations of epidermal growth factor receptor are associated with prolonged survival in non-small cell lung cancer patients treated with gefitinib or erlotinib

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

Screening for epidermal growth factor receptor mutations in lung cancer

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

Afatinib versus cisplatin-based chemotherapy for EGFR mutation-positive lung adenocarcinoma (LUX-Lung 3 and LUX-Lung 6): analysis of overall survival data from two randomised, phase 3 trials

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

Noninvasive detection of response and resistance in EGFR-mutant lung cancer using quantitative next-generation genotyping of cell-free plasma DNA.

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

Acquired EGFR C797S mutation mediates resistance to AZD9291 in non-small cell lung cancer harboring EGFR T790M.

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

Anticancer activities of histone deacetylase inhibitors

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

Quantitative high-throughput analysis of DNA methylation patterns by base-specific cleavage and mass spectrometry

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

SEPT9: A Specific Circulating Biomarker for Colorectal Cancer

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

Sensitive detection of colorectal cancer in peripheral blood by septin 9 DNA methylation assay

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

Performance of epigenetic markers SEPT9 and ALX4 in plasma for detection of colorectal precancerous lesions

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

DNA methylation markers and early recurrence in stage I lung cancer

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

Gene promoter methylation in plasma and sputum increases with lung cancer risk

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

SHOX2 DNA methylation is a biomarker for the diagnosis of lung cancer based on bronchial aspirates

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

EGFR Mutations in Non-Small-Cell Lung Cancer: Find, Divide, and Conquer.

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

Spatial and temporal diversity in genomic instability processes defines lung cancer evolution

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

Blood platelets contain tumor-derived RNA biomarkers

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

Platelets actively sequester angiogenesis regulators

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

Platelet-derived nucleotides promote tumor-cell transendothelial migration and metastasis via P2Y2 receptor.

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

SHOX2 DNA Methylation Is a Biomarker for the Diagnosis of Lung Cancer in Plasma

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

21 January 2018

Prognostic and predictive value of tumor-infiltrating lymphocytes in a phase III randomized adjuvant breast cancer trial in node-positive breast cancer comparing the addition of docetaxel to doxorubicin with doxorubicin-based chemotherapy: BIG 02-98

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4700220

28 November 2018

Tumor-infiltrating lymphocyte grade is an independent predictor of sentinel lymph node status and survival in patients with cutaneous melanoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4700220

28 November 2018

Tumor-infiltrating CD8+ lymphocytes predict clinical outcome in breast cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4700220

28 November 2018

FOXP3 expression and overall survival in breast cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4700220

28 November 2018

Inhibition of human neutrophil degranulation by transforming growth factor-beta1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4700220

28 November 2018

Regulation of trafficking receptor expression in human forkhead box P3+ regulatory T cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4700220

28 November 2018

Elevated TGF-beta1 secretion and down-modulation of NKG2D underlies impaired NK cytotoxicity in cancer patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4700220

28 November 2018

Smad3 is essential for TGF-beta 1 to suppress IL-2 production and TCR-induced proliferation, but not IL-2-induced proliferation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4700220

28 November 2018

Tumor infiltrating Foxp3+ regulatory T-cells are associated with recurrence in pathologic stage I NSCLC patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/26798582

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/26798582

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transforming growth factor-beta controls T helper type 1 cell development through regulation of natural killer cell interferon-gamma

1 reference

https://pubmed.ncbi.nlm.nih.gov/26798582

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transforming growth factor-beta 1 inhibits the production of IL-8 and the transmigration of neutrophils through activated endothelium

1 reference

https://pubmed.ncbi.nlm.nih.gov/26798582

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methylation of multiple genes as a candidate biomarker in non-small cell lung cancer

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

7 January 2021

based on heuristic

inferred from DOI database lookup

Promoter hypermethylation of multiple genes in sputum precedes lung cancer incidence in a high-risk cohort

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

7 January 2021

based on heuristic

inferred from DOI database lookup

Quantitative detection of EGFR mutations in circulating tumor DNA derived from lung adenocarcinomas

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

7 January 2021

based on heuristic

inferred from DOI database lookup

Changes in Concentration of DNA in Serum and Plasma during Storage of Blood Samples

1 reference

https://api.crossref.org/works/10.2217%2FBMM.16.6

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.3978/J.ISSN.2218-6751.2015.12.04

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

10.2217/BMM.16.6

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

reason for deprecated rank

incorrect identifier value

0 references

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