Exercise Counteracts Aging-Related Memory Impairment: A Potential Role for the Astrocytic Metabolic Shuttle (Q26752408)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27047373%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

title

Exercise Counteracts Aging-Related Memory Impairment: A Potential Role for the Astrocytic Metabolic Shuttle (English)

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31 March 2020

2

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31 March 2020

Yu-Min Kuo

5

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31 March 2020

author name string

Sheng-Feng Tsai

1

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31 March 2020

Marcus J Calkins

3

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31 March 2020

Shih-Ying Wu

4

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31 March 2020

language of work or name

English

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publication date

22 March 2016

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Frontiers in Aging Neuroscience

31 March 2020

published in

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31 March 2020

volume

8

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page(s)

57

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Lactate fuels the human brain during exercise

31 March 2020

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31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801859

3-hydroxyglutaric acid enhances glutamate uptake into astrocytes from cerebral cortex of young rats

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801859

Layer-specific dendritic regression of pyramidal cells with ageing in the human prefrontal cortex.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801859

Glial contribution to glutamate uptake at Schaffer collateral-commissural synapses in the hippocampus.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801859

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801859

Glutamate uptake stimulates Na+,K+-ATPase activity in astrocytes via activation of a distinct subunit highly sensitive to ouabain.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801859

Selective alteration of long-term potentiation-induced transcriptional response in hippocampus of aged, memory-impaired rats.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801859

Increase in single L-type calcium channels in hippocampal neurons during aging.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801859

Decreased concentrations of GLUT1 and GLUT3 glucose transporters in the brains of patients with Alzheimer's disease.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801859

Impairment of mitochondrial oxidative phosphorylation in the brain of aged mice.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801859

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801859

The effects of high Mg2+-to-Ca2+ ratios on frequency potentiation in hippocampal slices of young and aged rats.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801859

Reduced glucose transporter at the blood-brain barrier and in cerebral cortex in Alzheimer disease.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801859

Changes in Na+,K(+)-ATPase, Ca2(+)-ATPase and some soluble enzymes related to energy metabolism in brains of patients with Alzheimer's disease.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801859

Region‐specific age effects on AMPA sensitivity: Electrophysiological evidence for loss of synaptic contacts in hippocampal field CA1

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801859

Energy-efficient action potentials in hippocampal mossy fibers.

31 May 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2016.00057

LTP induction threshold change in old rats at the perforant path--granule cell synapse.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2016.00057

Competition between glucose and lactate as oxidative energy substrates in both neurons and astrocytes: a comparative NMR study.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2016.00057

Energy transfer from astrocytes to axons: the role of CNS glycogen

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2016.00057

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2016.00057

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2016.00057

Deriving the glutamate clearance time course from transporter currents in CA1 hippocampal astrocytes: transmitter uptake gets faster during development.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2016.00057

Age and strain differences in rat place learning and hippocampal dentate gyrus frequency-potentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2016.00057

Selective reduction of hippocampal dentate frequency potentiation in aged rats with impaired place learning.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2016.00057

Glutamatergic and GABAergic energy metabolism measured in the rat brain by (13) C NMR spectroscopy at 14.1 T.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2016.00057

Beta-amyloid25-35 inhibits glutamate uptake in cultured neurons and astrocytes: modulation of uptake as a survival mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2016.00057

Cooperative astrocyte and dendritic spine dynamics at hippocampal excitatory synapses.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2016.00057

The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C-Cdh1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2016.00057

Lactate, glucose and O2 uptake in human brain during recovery from maximal exercise.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2016.00057

Lactate oxidation at the mitochondria: a lactate-malate-aspartate shuttle at work

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2016.00057

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2016.00057

Study of GPR81, the lactate receptor, from distant species identifies residues and motifs critical for GPR81 functions

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2016.00057

Dependence of rat hippocampal c-Fos expression on intensity and duration of exercise.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2016.00057

Running exercise delays neurodegeneration in amygdala and hippocampus of Alzheimer's disease (APP/PS1) transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2016.00057

Aging and sex influence the anatomy of the rat anterior cingulate cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2016.00057

Dysregulation of memory-related proteins in the hippocampus of aged rats and their relation with cognitive impairment.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2016.00057

Hippocampal plasticity induced by primed burst, but not long-term potentiation, stimulation is impaired in area CA1 of aged Fischer 344 rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2016.00057

MCI conversion to dementia and the APOE genotype: a prediction study with FDG-PET.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2016.00057

Reduced hippocampal metabolism in MCI and AD: automated FDG-PET image analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2016.00057

Hippocampal mitochondrial dysfunction in rat aging

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2016.00057

CREB and the enhancement of long-term memory.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2016.00057

Neuronal activity drives localized blood-brain-barrier transport of serum insulin-like growth factor-I into the CNS.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2016.00057

Hypoxia and exercise provoke both lactate release and lactate oxidation by the human brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2016.00057

Astroglial metabolic networks sustain hippocampal synaptic transmission

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2016.00057

Region- and age-specific changes in glutamate transport in the AβPP23 mouse model for Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2016.00057

Acute exercise increases brain region-specific expression of MCT1, MCT2, MCT4, GLUT1, and COX IV proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2016.00057

Glutamate uptake is stimulated by extracellular S100B in hippocampal astrocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2016.00057

Blood lactate is an important energy source for the human brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2016.00057

Mechanism suppressing glycogen synthesis in neurons and its demise in progressive myoclonus epilepsy.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2016.00057

Memory impairment in cognitively impaired aged rats associated with decreased hippocampal CREB phosphorylation: reversal by procyanidins extracted from the lotus seedpod.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNAGI.2016.00057

Gene Microarrays in Hippocampal Aging: Statistical Profiling Identifies Novel Processes Correlated with Cognitive Impairment

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801859

Theta-frequency synaptic potentiation in CA1 in vitro distinguishes cognitively impaired from unimpaired aged Fischer 344 rats.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801859

Excitatory amino acid transporter EAAT-2 in tangle-bearing neurons in Alzheimer's disease.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801859

Circulating insulin-like growth factor I mediates effects of exercise on the brain.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801859

Role of temporal summation in age-related long-term potentiation-induction deficits.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801859

Trafficking between glia and neurons of TCA cycle intermediates and related metabolites.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801859

28 November 2018

1 reference

12 December 2020

A possible role of alanine for ammonia transfer between astrocytes and glutamatergic neurons

1 reference

12 December 2020

Neuron-glia metabolic coupling and plasticity

1 reference

12 December 2020

The human blood-brain barrier glucose transporter (GLUT1) is a glucose transporter of gray matter astrocytes

1 reference

12 December 2020

Rat brain and liver mitochondria develop oxidative stress and lose enzymatic activities on aging

1 reference

12 December 2020

Cerebral glucose and lactate consumption during cerebral activation by physical activity in humans

1 reference

12 December 2020

Identifiers

DOI

10.3389/FNAGI.2016.00057

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27047373%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27047373%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27047373%20AND%20SRC:MED&resulttype=core&format=json