The emerging roles and therapeutic potential of cyclin-dependent kinase 11 (CDK11) in human cancer (Q26751387)

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Jacson K Shen

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Quancheng Kan

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Zhenfeng Duan

Creative Commons Attribution 2.5 Generic

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language of work or name

English

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publication date

31 March 2016

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28 June 2016

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3 April 2019

28 September 2019

20 November 2019

10 December 2019

8 February 2021

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3 April 2019

28 September 2019

20 November 2019

10 December 2019

8 February 2021

5 references

3 April 2019

28 September 2019

20 November 2019

10 December 2019

on focus list of Wikimedia project

8 February 2021

ScienceSource

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ALS2CR7 (CDK15) attenuates TRAIL induced apoptosis by inducing phosphorylation of survivin Thr34

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Cyclin-dependent kinase 16/PCTAIRE kinase 1 is activated by cyclin Y and is essential for spermatogenesis

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Cyclin-dependent kinase 9-cyclin K functions in the replication stress response

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The RNP protein, RNPS1, associates with specific isoforms of the p34cdc2-related PITSLRE protein kinase in vivo

7 April 2017

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Molecular cloning and expression of alternatively spliced PITSLRE protein kinase isoforms

7 April 2017

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CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome

7 April 2017

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CHK2 kinase promotes pre-mRNA splicing via phosphorylating CDK11(p110)

7 April 2017

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Targeting cell cycle regulation in cancer therapy

7 April 2017

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Regulation of lipogenesis by cyclin-dependent kinase 8-mediated control of SREBP-1

7 April 2017

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Cell cycle kinases as therapeutic targets for cancer

7 April 2017

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CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity

7 April 2017

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Cyclin-dependent kinase pathways as targets for cancer treatment

7 April 2017

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The cyclin-dependent kinase 11p46 isoform interacts with RanBPM

7 April 2017

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7 April 2017

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Interaction of p58(PITSLRE), a G2/M-specific protein kinase, with cyclin D3

7 April 2017

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Multidrug resistance in cancer: role of ATP-dependent transporters

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PITSLRE p110 protein kinases associate with transcription complexes and affect their activity

7 April 2017

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Cleavage of PITSLRE kinases by ICE/CASP-1 and CPP32/CASP-3 during apoptosis induced by tumor necrosis factor

7 April 2017

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Molecular basis of differential selectivity of cyclobutyl-substituted imidazole inhibitors against CDKs: insights for rational drug design

7 April 2017

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LPS-stimulating astrocyte-conditioned medium causes neuronal apoptosis via increasing CDK11(p58) expression in PC12 cells through downregulating AKT pathway

7 April 2017

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Failure to proliferate and mitotic arrest of CDK11(p110/p58)-null mutant mice at the blastocyst stage of embryonic cell development

7 April 2017

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CDK11 in TREX/THOC Regulates HIV mRNA 3' End Processing

7 April 2017

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Identification of potential drug targets for tuberous sclerosis complex by synthetic screens combining CRISPR-based knockouts with RNAi

28 September 2017

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Palbociclib: A Novel Cyclin-Dependent Kinase Inhibitor for Hormone Receptor-Positive Advanced Breast Cancer

28 September 2017

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Enhancement of BACE1 Activity by p25/Cdk5-Mediated Phosphorylation in Alzheimer's Disease

28 September 2017

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CDK14 Contributes to Reactive Gliosis via Interaction with Cyclin Y in Rat Model of Spinal Cord Injury

28 September 2017

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Palbociclib: a first-in-class CDK4/CDK6 inhibitor for the treatment of hormone-receptor positive advanced breast cancer

28 September 2017

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28 September 2017

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Cyclin dependent kinase (CDK) inhibitors as anticancer drugs

28 September 2017

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Palbociclib in Hormone-Receptor-Positive Advanced Breast Cancer

28 September 2017

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Cyclin-Dependent Kinase Inhibitors as Anticancer Therapeutics

28 September 2017

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Cyclin-dependent kinase 11(p110) (CDK11(p110)) is crucial for human breast cancer cell proliferation and growth

28 September 2017

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Targeting cell cycle regulators in hematologic malignancies.

28 September 2017

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Preclinical evaluation of cyclin dependent kinase 11 and casein kinase 2 survival kinases as RNA interference targets for triple negative breast cancer therapy

28 September 2017

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Targeting CDK11 in osteosarcoma cells using the CRISPR-Cas9 system

28 September 2017

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28 September 2017

Cyclin-dependent kinases

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Palbociclib: an evidence-based review of its potential in the treatment of breast cancer

28 September 2017

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Sonic hedgehog signaling in the lung. From development to disease

28 September 2017

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PCTAIRE kinase 3/cyclin-dependent kinase 18 is activated through association with cyclin A and/or phosphorylation by protein kinase A.

28 September 2017

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Aberrant CDK4 amplification in refractory rhabdomyosarcoma as identified by genomic profiling

28 September 2017

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Cyclin-dependent kinase 11 (CDK11) is crucial in the growth of liposarcoma cells

28 September 2017

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28 September 2017

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The mechanisms of Hedgehog signalling and its roles in development and disease

28 September 2017

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Signaling through cyclin D-dependent kinases

28 September 2017

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Systematic kinome shRNA screening identifies CDK11 (PITSLRE) kinase expression is critical for osteosarcoma cell growth and proliferation

28 September 2017

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Cyclin dependent kinases in cancer: potential for therapeutic intervention

28 September 2017

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Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations

28 September 2017

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Identification of molecular vulnerabilities in human multiple myeloma cells by RNA interference lethality screening of the druggable genome

28 September 2017

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The cyclin-dependent kinase PITSLRE/CDK11 is required for successful autophagy

28 September 2017

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Pre-clinical characterization of CX-4945, a potent and selective small molecule inhibitor of CK2 for the treatment of cancer

28 September 2017

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28 September 2017

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Cyclin-dependent kinases in brain development and disease

28 September 2017

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Mislocalization of CDK11/PITSLRE, a regulator of the G2/M phase of the cell cycle, in Alzheimer disease

28 September 2017

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CDK11(p58) is required for centriole duplication and Plk4 recruitment to mitotic centrosomes

28 September 2017

1 reference

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The RNA binding motif protein 15B (RBM15B/OTT3) is a functional competitor of serine-arginine (SR) proteins and antagonizes the positive effect of the CDK11p110-cyclin L2α complex on splicing

28 September 2017

1 reference

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CDK19 is disrupted in a female patient with bilateral congenital retinal folds, microcephaly and mild mental retardation

28 September 2017

1 reference

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Vascular Endothelial Growth Factor Receptor-1 Is Synthetic Lethal to Aberrant {beta}-Catenin Activation in Colon Cancer

28 September 2017

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Kinome-wide RNAi studies in human multiple myeloma identify vulnerable kinase targets, including a lymphoid-restricted kinase, GRK6.

28 September 2017

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Cyclin-dependent kinases: a family portrait.

28 September 2017

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Hedgehog signaling in development and cancer.

28 September 2017

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Role of the cyclin-dependent kinase 9-related pathway in mammalian gene expression and human diseases

28 September 2017

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Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency

28 September 2017

1 reference

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Kinome siRNA screen identifies regulators of ciliogenesis and hedgehog signal transduction

28 September 2017

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Cdk11 is a RanGTP-dependent microtubule stabilization factor that regulates spindle assembly rate

28 September 2017

1 reference

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Characterization of cyclin L1 and L2 interactions with CDK11 and splicing factors: influence of cyclin L isoforms on splice site selection.

28 September 2017

1 reference

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CDK11(p58) is required for the maintenance of sister chromatid cohesion

28 September 2017

1 reference

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Second generation inhibitors of BCR-ABL for the treatment of imatinib-resistant chronic myeloid leukaemia

28 September 2017

1 reference

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14-3-3sigma controls mitotic translation to facilitate cytokinesis

28 September 2017

1 reference

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A structural perspective of CTD function

28 September 2017

1 reference

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Role of CDK/cyclin complexes in transcription and RNA splicing

28 September 2017

1 reference

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The cyclin-dependent kinase 11 interacts with 14-3-3 proteins

28 September 2017

1 reference

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Isolation and characterization of the human Cdc2L1 gene promoter.

28 September 2017

1 reference

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Regulation of stability of cyclin-dependent kinase CDK11p110 and a caspase-processed form, CDK11p46, by Hsp90.

28 September 2017

1 reference

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Cyclin dependent kinase 11 in RNA transcription and splicing

28 September 2017

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Identification and characterization of the human Cdc2l2 gene promoter

28 September 2017

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Casein kinase 2 interacts with cyclin-dependent kinase 11 (CDK11) in vivo and phosphorylates both the RNA polymerase II carboxyl-terminal domain and CDK11 in vitro

28 September 2017

1 reference

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PITSLRE protein kinase activity is associated with apoptosis

28 September 2017

1 reference

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CDK5 serves as a major control point in neurotransmitter release.

28 September 2017

1 reference

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Cyclin-dependent kinase 4 overexpression is mostly independent of gene amplification and constitutes an independent prognosticator for nasopharyngeal carcinoma.

31 May 2018

1 reference

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CDK11(p58) kinase activity is required to protect sister chromatid cohesion at centromeres in mitosis.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5130049

Cdk11-cyclinL controls the assembly of the RNA polymerase II mediator complex

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5130049

Polypyrimidine tract-binding protein regulates the cell cycle through IRES-dependent translation of CDK11(p58) in mouse embryonic stem cells.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5130049

A genome-wide RNA interference screen in Drosophila melanogaster cells for new components of the Hh signaling pathway

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5130049

Cyclin-dependent kinase 11(p110) activity in the absence of CK2.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5130049

Fas-induced apoptosis in human malignant melanoma cell lines is associated with the activation of the p34(cdc2)-related PITSLRE protein kinases

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27049727