Modulation of Innate Immune Mechanisms to Enhance Leishmania Vaccine-Induced Immunity: Role of Coinhibitory Molecules (Q26744635)

Europe PubMed Central

title

Modulation of Innate Immune Mechanisms to Enhance Leishmania Vaccine-Induced Immunity: Role of Coinhibitory Molecules (English)

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6

Hira L Nakhasi

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author name string

Sreenivas Gannavaram

1

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Parna Bhattacharya

2

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Nevien Ismail

3

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Amit Kaul

4

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Rakesh Singh

5

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language of work or name

English

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publication date

2016

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published in

Frontiers in Immunology

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Leishmaniasis worldwide and global estimates of its incidence

volume

7

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page(s)

187

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cites work

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28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865500

Dendritic cell-based vaccination strategies: induction of protective immunity against leishmaniasis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865500

Leishmania major promastigotes inhibit dendritic cell motility in vitro

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865500

CTLA-4 down-regulates the protective anticryptococcal cell-mediated immune response

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865500

Uptake of Leishmania major amastigotes results in activation and interleukin 12 release from murine skin-derived dendritic cells: implications for the initiation of anti-Leishmania immunity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865500

Dendritic cells, but not macrophages, produce IL-12 immediately following Leishmania donovani infection

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865500

Leishmania-infected macrophages sequester endogenously synthesized parasite antigens from presentation to CD4+ T cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865500

Leishmania major-parasitized macrophages augment Th2-type T cell activation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865500

Deficient expression of co-stimulatory molecules on Leishmania-infected macrophages.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865500

Activation of human dendritic cells through CD40 cross-linking.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865500

High levels of CD4⁺ CTLA-4⁺ Treg cells and CCR5 density in HIV-1-infected patients with visceral leishmaniasis.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865500

Tissue requirements for establishing long-term CD4+ T cell-mediated immunity following Leishmania donovani infection

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865500

Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865500

Regulation of Trypanosoma cruzi-induced myocarditis by programmed death cell receptor 1.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865500

Dendritic cell (DC)-based anti-infective strategies: DCs engineered to secrete IL-12 are a potent vaccine in a murine model of an intracellular infection

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865500

Role of L3T4+ and LyT-2+ cells in experimental visceral leishmaniasis

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865500

The inhibition of arginase by N(omega)-hydroxy-l-arginine controls the growth of Leishmania inside macrophages

31 May 2018

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2016.00187

Arginase and polyamine synthesis are key factors in the regulation of experimental leishmaniasis in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2016.00187

Arginase I induction in macrophages, triggered by Th2-type cytokines, supports the growth of intracellular Leishmania parasites.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2016.00187

Monocyte-derived dendritic cells formed at the infection site control the induction of protective T helper 1 responses against Leishmania

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2016.00187

Leishmania evades host immunity by inhibiting antigen cross-presentation through direct cleavage of the SNARE VAMP8.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2016.00187

Fragments of antigen-loaded dendritic cells (DC) and DC-derived exosomes induce protective immunity against Leishmania major.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2016.00187

Central memory T cells mediate long-term immunity to Leishmania major in the absence of persistent parasites.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2016.00187

The common gamma-chain cytokines IL-2, IL-7, IL-15, and IL-21 induce the expression of programmed death-1 and its ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2016.00187

Dysfunction and functional restoration of HCV-specific CD8 responses in chronic hepatitis C virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2016.00187

Restoration of HCV-specific T cell functions by PD-1/PD-L1 blockade in HCV infection: effect of viremia levels and antiviral treatment.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2016.00187

The inhibitory CD200R is differentially expressed on human and mouse T and B lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2016.00187

Intracellular replication-deficient Leishmania donovani induces long lasting protective immunity against visceral leishmaniasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2016.00187

Expression and contribution of B7-1 (CD80) and B7-2 (CD86) in the early immune response to Leishmania major infection.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865500

Antigen-pulsed epidermal Langerhans cells protect susceptible mice from infection with the intracellular parasite Leishmania major

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865500

Macrophage killing of Leishmania parasite in vivo is mediated by nitric oxide from L-arginine

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4865500

The development of a Th1-type response and resistance to Leishmania major infection in the absence of CD40-CD40L costimulation

28 November 2018

1 reference

12 December 2020

Critical role of dendritic cells in determining the Th1/Th2 balance upon Leishmania major infection

1 reference

12 December 2020

Cell-mediated immune response in experimental visceral leishmaniasis. II. Oxygen-dependent killing of intracellular Leishmania donovani amastigotes

1 reference

12 December 2020

Vaccination with Leishmania mexicana LPG induces PD-1 in CD8⁺ and PD-L2 in macrophages thereby suppressing the immune response: a model to assess vaccine efficacy

1 reference

12 December 2020

Protective role of CD40 in Leishmania major infection at two distinct phases of cell-mediated immunity

1 reference

12 December 2020

A critical function for CD200 in lung immune homeostasis and the severity of influenza infection

1 reference

12 December 2020