Kynurenine Aminotransferase Isozyme Inhibitors: A Review (Q26744492)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27314340%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

W. Bret Church

series ordinal

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27314340%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

author name string

Guanchen Sun

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27314340%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Gayan S Jayawickrama

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27314340%20AND%20SRC:MED&resulttype=core&format=json

International Journal of Molecular Sciences

9 June 2020

language of work or name

English

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publication date

2016

0 references

15 June 2016

3 references

28 September 2019

2 October 2019

20 January 2021

4 references

28 September 2019

2 October 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27314340%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

20 January 2021

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27314340%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

issue

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27314340%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution

9 June 2020

page(s)

946

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copyright license

3 references

28 September 2019

2 October 2019

20 January 2021

0 references

The Risk of Fluoroquinolone-induced Tendinopathy and Tendon Rupture: What Does The Clinician Need To Know?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4926479

Structural insight into the inhibition of human kynurenine aminotransferase I/glutamine transaminase K

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4926479

Biochemical and structural properties of mouse kynurenine aminotransferase III

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4926479

Substrate specificity and structure of human aminoadipate aminotransferase/kynurenine aminotransferase II

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4926479

Crystal structure of human kynurenine aminotransferase I

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4926479

Kynurenines in the mammalian brain: when physiology meets pathology

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4926479

Recombinant expression, purification and crystallographic studies of the mature form of human mitochondrial aspartate aminotransferase

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4926479

Structure-Based Design of Irreversible Human KAT II Inhibitors: Discovery of New Potency-Enhancing Interactions

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4926479

PF-04859989 as a template for structure-based drug design: identification of new pyrazole series of irreversible KAT II inhibitors with improved lipophilic efficiency

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4926479

Biochemical and structural characterization of mouse mitochondrial aspartate aminotransferase, a newly identified kynurenine aminotransferase-IV

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4926479

Crystal Structure-Based Selective Targeting of the Pyridoxal 5′-Phosphate Dependent Enzyme Kynurenine Aminotransferase II for Cognitive Enhancement

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4926479

Structure, expression, and function of kynurenine aminotransferases in human and rodent brains

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4926479

Crystal structure of human kynurenine aminotransferase II, a drug target for the treatment of schizophrenia

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4926479

The kynurenic acid hypothesis of schizophrenia

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4926479

Two kynurenine aminotransferases in human brain

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4926479

Characterization of the human gene encoding alpha-aminoadipate aminotransferase (AADAT)

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4926479

Structure of the PLP-Form of the Human Kynurenine Aminotransferase II in a Novel Spacegroup at 1.83 Å Resolution

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4926479

Expression, purification and crystallization of human kynurenine aminotransferase 2 exploiting a highly optimized codon set.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4926479

A genome-wide association study of kynurenic acid in cerebrospinal fluid: implications for psychosis and cognitive impairment in bipolar disorder

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4926479

ω-Amidase: an underappreciated, but important enzyme in L-glutamine and L-asparagine metabolism; relevance to sulfur and nitrogen metabolism, tumor biology and hyperammonemic diseases.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4926479

Challenges and Opportunities in the Discovery of New Therapeutics Targeting the Kynurenine Pathway

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4926479

Kynurenine Aminotransferases and the Prospects of Inhibitors for the Treatment of Schizophrenia

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4926479

Discovery of Brain-Penetrant, Irreversible Kynurenine Aminotransferase II Inhibitors for Schizophrenia.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4926479

Essential structural features of novel antischizophrenic drugs: a review

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4926479

Unexpected effects of peripherally administered kynurenic acid on cortical spreading depression and related blood-brain barrier permeability.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4926479

Kynurenines in the CNS: recent advances and new questions.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4926479

The resurgence of covalent drugs

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4926479

IC50-to-Ki: a web-based tool for converting IC50 to Ki values for inhibitors of enzyme activity and ligand binding

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4926479

Characterization of kynurenine aminotransferase III, a novel member of a phylogenetically conserved KAT family.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4926479

The role of glutamine transaminase K (GTK) in sulfur and alpha-keto acid metabolism in the brain, and in the possible bioactivation of neurotoxicants

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4926479

Endogenous kynurenines as targets for drug discovery and development

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4926479

Peripheral neuropathy associated with fluoroquinolones.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4926479

Seizures associated with fluoroquinolones

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4926479

Structure, evolution and action of vitamin B6-dependent enzymes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4926479

Isolation and properties of highly purified glutamine transaminase

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4926479

D-Cycloserine lowers kynurenic acid formation--new mechanism of action.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4926479

Levofloxacin-induced acute psychosis

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4926479

Specific inhibition of kynurenate synthesis enhances extracellular dopamine levels in the rodent striatum.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4926479

Astrocytic localization of kynurenine aminotransferase II in the rat brain visualized by immunocytochemistry.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4926479

Brain-specific modulation of kynurenic acid synthesis in the rat.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4926479

In vitro trials to counteract the inhibitory effect of beta-oestradiol and ethynyloestradiol on the B6-dependent kynurenine aminotransferase enzyme

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4926479

Homology modeling of human kynurenine aminotransferase III and observations on inhibitor binding using molecular docking.

31 May 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS17060946

pH dependence, substrate specificity and inhibition of human kynurenine aminotransferase I.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS17060946

Homocysteine, a risk factor for atherosclerosis, biphasically changes the endothelial production of kynurenic acid.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS17060946

Kynurenine pathway metabolism in human astrocytes: a paradox for neuronal protection

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS17060946

Sequence variants in kynurenine aminotransferase II (KAT II) orthologs determine different potencies of the inhibitor S-ESBA.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS17060946

Kynurenic acid production in cultured bovine aortic endothelial cells. Homocysteine is a potent inhibitor.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS17060946

L-cysteine sulphinate, endogenous sulphur-containing amino acid, inhibits rat brain kynurenic acid production via selective interference with kynurenine aminotransferase II.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS17060946

Impairment of brain kynurenic acid production by glutamate metabotropic receptor agonists.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS17060946

Modulators of the Kynurenine Pathway of Tryptophan Metabolism: Synthesis and Preliminary Biological Evaluation of (S)-4-(Ethylsulfonyl)benzoylalanine, a Potent and Selective Kynurenine Aminotransferase II (KAT II) Inhibitor

21 January 2018

1 reference

12 December 2020

Estrogen-enzyme interactions: Inhibition and protection of kynurenine transaminase by the sulfate esters of diethylstilbestrol, estradiol, and estrone

1 reference

12 December 2020

In vivo inhibition of kynurenine aminotransferase activity by isonicotinic acid hydrazide in rats

1 reference

12 December 2020

In vivo and in vitro studies on the effects of some phenothiazines and sulpiride on kynurenine metabolism

1 reference

12 December 2020

Design and synthesis of novel inhibitors of human kynurenine aminotransferase-I

1 reference

12 December 2020

Some metabotropic glutamate receptor ligands reduce kynurenate synthesis in rats by intracellular inhibition of kynurenine aminotransferase II

1 reference

12 December 2020

Identifiers

DOI

10.3390/IJMS17060946

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27314340%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27314340%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

PubMed publication ID

27314340

2 references