Identification and Characterization of Novel Broad-Spectrum Inhibitors of the Flavivirus Methyltransferase (Q26700125)

4

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Hongmin Li

object named as

Hongmin Li

8

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Laura D Kramer

7

object named as

Laura D Kramer

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author name string

Hui Chen

2

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Zhong Li

3

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Susan A Jones

5

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Jing Zhang

Open Babel: An open chemical toolbox

6

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language of work or name

English

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publication date

14 August 2015

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published in

ACS Infectious Diseases

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volume

1

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issue

8

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page(s)

340-349

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cites work

1 reference

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Structural and Functional Analyses of a Conserved Hydrophobic Pocket of Flavivirus Methyltransferase

7 April 2017

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Structure and functionality in flavivirus NS-proteins: perspectives for drug design

7 April 2017

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Molecular targets for flavivirus drug discovery

7 April 2017

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Crystal structure of dengue virus methyltransferase without S-adenosyl-L-methionine

7 April 2017

1 reference

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Assessment of Dengue virus helicase and methyltransferase as targets for fragment-based drug discovery

7 April 2017

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Small Molecule Inhibitors That Selectively Block Dengue Virus Methyltransferase

7 April 2017

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Phosphorylation of yellow fever virus NS5 alters methyltransferase activity

7 April 2017

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Separate molecules of West Nile virus methyltransferase can independently catalyze the N7 and 2′-O methylations of viral RNA cap

7 April 2017

1 reference

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West Nile Virus Methyltransferase Catalyzes Two Methylations of the Viral RNA Cap through a Substrate-Repositioning Mechanism

7 April 2017

1 reference

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Structure and Function of Flavivirus NS5 Methyltransferase

7 April 2017

1 reference

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West Nile Virus 5'-Cap Structure Is Formed by Sequential Guanine N-7 and Ribose 2'-O Methylations by Nonstructural Protein 5

7 April 2017

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Identification of small molecule inhibitors of anthrax lethal factor

7 April 2017

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trans-Complementation of flavivirus RNA polymerase gene NS5 by using Kunjin virus replicon-expressing BHK cells

7 April 2017

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Features and development of Coot

7 April 2017

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AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

7 April 2017

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2'-O methylation of internal adenosine by flavivirus NS5 methyltransferase

7 April 2017

1 reference

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New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays

7 April 2017

1 reference

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The dengue virus NS5 protein as a target for drug discovery

7 April 2017

1 reference

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Refolding of a fully functional flavivirus methyltransferase revealed that S-adenosyl methionine but not S-adenosyl homocysteine is copurified with flavivirus methyltransferase

28 September 2017

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S-adenosyl-homocysteine is a weakly bound inhibitor for a flaviviral methyltransferase

28 September 2017

1 reference

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Selective inhibition of the West Nile virus methyltransferase by nucleoside analogs

28 September 2017

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Flaviviruses and flavivirus vaccines

28 September 2017

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Encephalitis caused by flaviviruses

28 September 2017

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Flavivirus RNA cap methyltransferase: structure, function, and inhibition

28 September 2017

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Keratinocytes are cell targets of West Nile virus in vivo

28 September 2017

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Novel inhibitors of dengue virus methyltransferase: discovery by in vitro-driven virtual screening on a desktop computer grid

28 September 2017

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Biochemical characterization of the (nucleoside-2'O)-methyltransferase activity of dengue virus protein NS5 using purified capped RNA oligonucleotides (7Me)GpppAC(n) and GpppAC(n).

28 September 2017

1 reference

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Identification and characterization of inhibitors of West Nile virus

28 September 2017

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Flaviviral methyltransferase/RNA interaction: structural basis for enzyme inhibition

28 September 2017

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A scintillation proximity assay for dengue virus NS5 2'-O-methyltransferase-kinetic and inhibition analyses.

28 September 2017

1 reference

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Surfen, a small molecule antagonist of heparan sulfate

28 September 2017

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Mutagenesis of the dengue virus type 2 NS5 methyltransferase domain

28 September 2017

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Virtual screening and bioassay study of novel inhibitors for dengue virus mRNA cap (nucleoside-2'O)-methyltransferase

28 September 2017

1 reference

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High-throughput assays for promiscuous inhibitors.

28 September 2017

1 reference

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A structural basis for the inhibition of the NS5 dengue virus mRNA 2'-O-methyltransferase domain by ribavirin 5'-triphosphate.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4696607

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4696607

A detergent-based assay for the detection of promiscuous inhibitors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4696607

Processing of X-ray diffraction data collected in oscillation mode

31 May 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26726314