Interleukin 18 (Q2657109)

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mammalian protein found in Homo sapiens

iboctadekin
interleukin 18 (interferon-gamma-inducing factor)
interleukin-18
Interferon gamma-inducing factor
interleukin-1 gamma
IFN-gamma-inducing factor
IL-1 gamma
IL18

Language	Label	Description	Also known as
English	Interleukin 18	mammalian protein found in Homo sapiens	iboctadekin interleukin 18 (interferon-gamma-inducing factor) interleukin-18 Interferon gamma-inducing factor interleukin-1 gamma IFN-gamma-inducing factor IL-1 gamma IL18

Statements

1 reference

13 November 2019

UniProt protein ID

Cytokine IL1/FGF

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q14116

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q14116

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

cytokine activity

determination method

8 references

8 April 2019

Interleukin-18 induces rheumatoid arthritis synovial fibroblast CXC chemokine production through NFkappaB activation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

8 April 2019

Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

8 April 2019

The structure and binding mode of interleukin-18

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

8 April 2019

The structural basis for receptor recognition of human interleukin-18

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

extracellular region

determination method

3 references

8 April 2019

Interleukin-18 induces rheumatoid arthritis synovial fibroblast CXC chemokine production through NFkappaB activation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

extracellular space

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

8 April 2019

Pro/anti-inflammatory cytokines in the pathogenesis of premature coronary artery disease

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

biological process

positive regulation of inflammatory response

determination method

1 reference

8 April 2019

Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

cell-cell signaling

determination method

1 reference

8 April 2019

Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

cellular response to organic cyclic compound

determination method

1 reference

8 April 2019

Inhibitory effects of honokiol on lipopolysaccharide-induced cellular responses and signaling events in human renal mesangial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

type 2 immune response

determination method

1 reference

8 April 2019

Regulation of Th1 and Th2 immune responses by IL-18

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

determination method

1 reference

8 April 2019

Inhibitory effects of honokiol on lipopolysaccharide-induced cellular responses and signaling events in human renal mesangial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

positive regulation of natural killer cell proliferation

determination method

1 reference

8 April 2019

IL-23 modulates CD56+/CD3- NK cell and CD56+/CD3+ NK-like T cell function differentially from IL-12

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

determination method

1 reference

8 April 2019

Interleukin-18 promotes sleep in rabbits and rats

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

regulation of cell adhesion

determination method

1 reference

8 April 2019

A novel role for interleukin-18 in adhesion molecule induction through NF kappa B and phosphatidylinositol (PI) 3-kinase-dependent signal transduction pathways

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

positive regulation of NK T cell proliferation

determination method

1 reference

8 April 2019

IL-23 modulates CD56+/CD3- NK cell and CD56+/CD3+ NK-like T cell function differentially from IL-12

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

positive regulation of granulocyte macrophage colony-stimulating factor production

determination method

1 reference

8 April 2019

Salmonella induced IL-23 and IL-1beta allow for IL-12 production by monocytes and Mphi1 through induction of IFN-gamma in CD56 NK/NK-like T cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

positive regulation of tissue remodeling

determination method

1 reference

8 April 2019

Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

determination method

1 reference

8 April 2019

Evidence of IL-18 as a novel angiogenic mediator

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

T-helper 1 type immune response

determination method

1 reference

8 April 2019

Interferon-gamma-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin-12 for interferon-gamma production

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

positive regulation of interleukin-17 production

determination method

1 reference

8 April 2019

Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

inflammatory response

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

8 April 2019

Inhibitory effects of honokiol on lipopolysaccharide-induced cellular responses and signaling events in human renal mesangial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

lipopolysaccharide-mediated signaling pathway

determination method

1 reference

8 April 2019

Inhibitory effects of honokiol on lipopolysaccharide-induced cellular responses and signaling events in human renal mesangial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

positive regulation of activated T cell proliferation

determination method

1 reference

8 April 2019

Interferon-gamma-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin-12 for interferon-gamma production

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

positive regulation of protein kinase B signaling

determination method

1 reference

8 April 2019

Interleukin-18/WNT1-inducible signaling pathway protein-1 signaling mediates human saphenous vein smooth muscle cell proliferation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

positive regulation of phosphatidylinositol 3-kinase signaling

determination method

1 reference

8 April 2019

Interleukin-18/WNT1-inducible signaling pathway protein-1 signaling mediates human saphenous vein smooth muscle cell proliferation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

positive regulation of smooth muscle cell proliferation

determination method

1 reference

8 April 2019

Interleukin-18/WNT1-inducible signaling pathway protein-1 signaling mediates human saphenous vein smooth muscle cell proliferation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

activation of protein kinase B activity

determination method

1 reference

8 April 2019

Interleukin-18/WNT1-inducible signaling pathway protein-1 signaling mediates human saphenous vein smooth muscle cell proliferation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

positive regulation of transcription by RNA polymerase II

determination method

1 reference

8 April 2019

Interleukin-18 may lead to benign prostatic hyperplasia via thrombospondin-1 production in prostatic smooth muscle cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

positive regulation of tyrosine phosphorylation of STAT protein

determination method

1 reference

8 April 2019

IL-18 activates STAT3 in the natural killer cell line 92, augments cytotoxic activity, and mediates IFN-gamma production by the stress kinase p38 and by the extracellular regulated kinases p44erk-1 and p42erk-21

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

positive regulation of gene expression

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

natural killer cell activation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

positive regulation of interferon-gamma production

determination method

5 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

8 April 2019

The structure and binding mode of interleukin-18

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

8 April 2019

IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

8 April 2019

IL-23 modulates CD56+/CD3- NK cell and CD56+/CD3+ NK-like T cell function differentially from IL-12

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

8 April 2019

Salmonella induced IL-23 and IL-1beta allow for IL-12 production by monocytes and Mphi1 through induction of IFN-gamma in CD56 NK/NK-like T cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

negative regulation of myoblast differentiation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

cell population proliferation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

regulation of signaling receptor activity

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

interleukin-6 production

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

T-helper 1 cell cytokine production

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

neutrophil activation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

natural killer cell mediated cytotoxicity

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

cytokine-mediated signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

interleukin-18-mediated signaling pathway

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

8 April 2019

The structural basis for receptor recognition of human interleukin-18

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

8 April 2019

Interleukin-18/WNT1-inducible signaling pathway protein-1 signaling mediates human saphenous vein smooth muscle cell proliferation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

positive regulation of NIK/NF-kappaB signaling

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

immune response

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

positive regulation of NF-kappaB transcription factor activity

determination method

1 reference

8 April 2019

The structural basis for receptor recognition of human interleukin-18

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

positive regulation of T-helper 1 cell cytokine production

determination method

1 reference

8 April 2019

IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

positive regulation of neuroinflammatory response

determination method

1 reference

8 April 2019

Role of TNF in mast cell neuroinflammation and pain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116

determination method

Gene Atlas image

PBB GE IL18 206295 at fs.png
732 × 530; 12 KB

0 references

Identifiers

CAS Registry Number

0 references

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000280357

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000280357

ENSP00000434161

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000434161

ENSP00000434561

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000434561

1 reference

Freebase Data Dumps

publication date

28 October 2013

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

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Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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