α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation (Q26269838)

Proceedings of the National Academy of Sciences of the United States of America

GOA release 2020-03-11

1 reference

3

Thomas C Südhof

Thomas C

Südhof

1 reference

19 October 2023

1

Jacqueline Burré

Jacqueline

Burré

1 reference

19 October 2023

2

Manu Sharma

Manu

Sharma

1 reference

19 October 2023

language of work or name

English

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publication date

7 October 2014

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published in

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volume

111

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page(s)

E4274-83

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issue

40

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describes a project that uses

ImageQuant

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4210039/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Properties of native brain α-synuclein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210039

Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210039

Systematic mutagenesis of α-synuclein reveals distinct sequence requirements for physiological and pathological activities

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210039

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210039

Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210039

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210039

Synaptic vesicle membrane fusion complex: action of clostridial neurotoxins on assembly

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210039

alpha-Synuclein locus triplication causes Parkinson's disease

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210039

Alpha-synuclein in Lewy bodies

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210039

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210039

Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brain

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210039

Solid-state ¹³C NMR reveals annealing of raft-like membranes containing cholesterol by the intrinsically disordered protein α-Synuclein

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210039

Membrane-bound alpha-synuclein has a high aggregation propensity and the ability to seed the aggregation of the cytosolic form

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210039

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210039

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210039

Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210039

Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210039

BAR domain scaffolds in dynamin-mediated membrane fission

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210039

A new method for quantitative immunoblotting of endogenous α-synuclein

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210039

Membrane remodeling by α-synuclein and effects on amyloid formation.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210039

Transfer of human α-synuclein from the olfactory bulb to interconnected brain regions in mice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210039

α-Synuclein oligomers with broken helical conformation form lipoprotein nanoparticles

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210039

A novel α-synuclein missense mutation in Parkinson disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210039

α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson's disease and multiple system atrophy?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210039

In vivo cross-linking reveals principally oligomeric forms of α-synuclein and β-synuclein in neurons and non-neural cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210039

α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210039

A soluble α-synuclein construct forms a dynamic tetramer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210039

Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210039

Alpha-synuclein populates both elongated and broken helix states on small unilamellar vesicles

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210039

Differential phospholipid binding of alpha-synuclein variants implicated in Parkinson's disease revealed by solution NMR spectroscopy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210039

Analysis of the synaptic vesicle proteome using three gel-based protein separation techniques

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210039

BAR domains and membrane curvature: bringing your curves to the BAR.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210039

Structure and dynamics of micelle-bound human alpha-synuclein

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210039

Glutaraldehyde: behavior in aqueous solution, reaction with proteins, and application to enzyme crosslinking

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210039

New chemical crosslinking methods for the identification of transient protein-protein interactions with multiprotein complexes.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210039

Structure of membrane-bound alpha-synuclein studied by site-directed spin labeling

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210039

A broken alpha -helix in folded alpha -Synuclein

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210039

Lipid droplet binding and oligomerization properties of the Parkinson's disease protein alpha-synuclein

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210039

NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210039

The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210039

Characterization of a novel protein regulated during the critical period for song learning in the zebra finch.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210039

α-Synuclein senses lipid packing defects and induces lateral expansion of lipids leading to membrane remodeling

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210039

NACP, a presynaptic protein, immunoreactivity in Lewy bodies in Parkinson's disease.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210039

Lewy body in neurodegeneration with brain iron accumulation type 1 is immunoreactive for alpha-synuclein.

31 May 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1416598111

Multiple-system atrophy: a new alpha-synuclein disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1416598111

Alpha-synuclein has a high affinity for packing defects in a bilayer membrane: a thermodynamics study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1416598111

Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1416598111

Lipid rafts mediate the synaptic localization of alpha-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1416598111

Comparison of structure and dynamics of micelle-bound human alpha-synuclein and Parkinson disease variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1416598111

Membrane binding and self-association of alpha-synucleins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1416598111

Lipid binding inhibits alpha-synuclein fibril formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1416598111

alpha-Synuclein-synaptosomal membrane interactions: implications for fibrillogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1416598111

Defective membrane interactions of familial Parkinson's disease mutant A30P alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1416598111

Evidence that the precursor protein of non-A beta component of Alzheimer's disease amyloid (NACP) has an extended structure primarily composed of random-coil.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4210039

alpha-Synuclein membrane interactions and lipid specificity

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25246573

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Causal relation between alpha-synuclein gene duplication and familial Parkinson's disease

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25246573

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1416598111

1 reference

671107

ADS bibcode

2014PNAS..111E4274B

0 references

671107

1 reference

1 reference

1 reference