Synthesis and preliminary cytotoxicity study of a cephalosporin-CC-1065 analogue prodrug (Q24794696)

2

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Susan C Wright

3

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Hong Wang

4

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James W Larrick

Synthesis and preliminary biological evaluations of CC-1065 analogues: effects of different linkers and terminal amides on biological activity

5

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language of work or name

1 reference

2001

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published in

BMC Chemical Biology

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volume

1

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issue

1

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page(s)

4

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cites work

1 reference

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Anticancer prodrugs for application in monotherapy: targeting hypoxia, tumor-associated enzymes, and receptors

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Monoclonal antibody therapy for solid tumors

28 September 2017

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Effects of minor groove binding drugs on the interaction of TATA box binding protein and TFIIA with DNA.

28 September 2017

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The chemistry, mechanism of action and biological properties of CC-1065, a potent antitumor antibiotic

28 September 2017

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Antibody directed enzymes revive anti-cancer prodrugs concept

28 September 2017

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Anti-tumor effects of antibody-alkaline phosphatase conjugates in combination with etoposide phosphate

28 September 2017

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CC-1065 (NSC-298223), a new antitumor antibiotic. Production, in vitro biological activity, microbiological assays and taxonomy of the producing microorganism

28 September 2017

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Comparative Stability of Cephalosporins in Aqueous Solution: Kinetics and Mechanisms of Degradation

28 September 2017

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Cephalosporin derivatives of doxorubicin as prodrugs for activation by monoclonal antibody-beta-lactamase conjugates

28 September 2017

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Unconjugated antibodies for cancer therapy: lessons from the clinic.

28 September 2017

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Regressions and cures of melanoma xenografts following treatment with monoclonal antibody beta-lactamase conjugates in combination with anticancer prodrugs.

30 May 2018

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Monoclonal antibody-beta-lactamase conjugates for the activation of a cephalosporin mustard prodrug

30 May 2018

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Substituent effects within the DNA binding subunit of CBI analogues of the duocarmycins and CC-1065.

30 May 2018

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Chemotherapeutic drug activation of the AP24 protease in apoptosis: requirement for caspase 3-like-proteases

28 November 2018

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Site-specific prodrug activation by antibody-beta-lactamase conjugates: regression and long-term growth inhibition of human colon carcinoma xenograft models.

28 November 2018

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Antitumor activities of a cephalosporin prodrug in combination with monoclonal antibody-beta-lactamase conjugates.

28 November 2018

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Development of a humanized disulfide-stabilized anti-p185HER2 Fv-beta-lactamase fusion protein for activation of a cephalosporin doxorubicin prodrug.

28 November 2018

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Synthesis and beta-lactamase-mediated activation of a cephalosporin-taxol prodrug

28 November 2018

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12 December 2020

CC-1065 (NSC 298223), a potent new antitumor agent improved production and isolation, characterization and antitumor activity

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12 December 2020

Preliminary toxicity studies with the DNA-binding antibiotic, CC-1065

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12 December 2020

Reaction of the antitumor antibiotic CC-1065 with DNA. Location of the site of thermally induced strand breakage and analysis of DNA sequence specificity

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12 December 2020

CC-1065 (NSC 298223), a most potent antitumor agent: kinetics of inhibition of growth, DNA synthesis, and cell survival

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12 December 2020

Prodrugs in cancer chemotherapy

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12 December 2020

Structure of CC-1065 (NSC-298223), a new antitumor antibiotic

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12 December 2020

Synthesis of 1-substituted 3-(chloromethyl)-6-aminoindoline (6-amino-seco-CI) DNA minor groove alkylating agents and structure-activity relationships for their cytotoxicity

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12 December 2020

The novel cyclopropapyrroloindole(CPI) bisalkylators bearing 3,3'-(1,4-phenylene)diacryloyl group as a linker

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12 December 2020

Reaction of the antitumor antibiotic CC-1065 with DNA: structure of a DNA adduct with DNA sequence specificity

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12 December 2020