The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors (Q24681206)

2

object named as

Carole A Oskeritzian

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author name string

Shawn G Payne

1

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Rachael Griffiths

3

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Preeti Subramanian

4

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Suzanne E Barbour

5

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Charles E Chalfant

6

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Sheldon Milstien

cPLA2 is phosphorylated and activated by MAP kinase

7

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language of work or name

English

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publication date

1 February 2007

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published in

Blood

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volume

109

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issue

3

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page(s)

1077-85

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cites work

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Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720

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Secretory phospholipase A2 receptor-mediated activation of cytosolic phospholipase A2 in murine bone marrow-derived mast cells

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IgE-dependent activation of sphingosine kinases 1 and 2 and secretion of sphingosine 1-phosphate requires Fyn kinase and contributes to mast cell responses

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Transient T cell accumulation in lymph nodes and sustained lymphopenia in mice treated with FTY720.

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FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function.

28 September 2017

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Transactivation of sphingosine-1-phosphate receptors by FcepsilonRI triggering is required for normal mast cell degranulation and chemotaxis

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28 September 2017

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Characterization of novel stem cell factor responsive human mast cell lines LAD 1 and 2 established from a patient with mast cell sarcoma/leukemia; activation following aggregation of FcepsilonRI or FcgammaRI.

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The immune modulator FYT720 prevents autoimmune diabetes in nonobese diabetic mice☆

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FTY720 stimulates multidrug transporter- and cysteinyl leukotriene-dependent T cell chemotaxis to lymph nodes

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Marked prevention of tumor growth and metastasis by a novel immunosuppressive agent, FTY720, in mouse breast cancer models.

28 September 2017

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1 reference

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1 reference

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1 reference

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28 November 2018

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Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720.

28 November 2018

1 reference

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28 November 2018

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Sphingosine 1-phosphate receptors regulate chemokine-driven transendothelial migration of lymph node but not splenic T cells.

28 November 2018

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28 November 2018

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28 November 2018

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28 November 2018

1 reference

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The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G-protein-coupled receptors

28 November 2018

1 reference

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Inhibition of Th1- and Th2-mediated airway inflammation by the sphingosine 1-phosphate receptor agonist FTY720.

28 November 2018

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Amelioration of experimental autoimmune encephalomyelitis in Lewis rats by FTY720 treatment

28 November 2018

1 reference

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Sphingosine-1-phosphate receptor agonism impairs the efficiency of the local immune response by altering trafficking of naive and antigen-activated CD4+ T cells

28 November 2018

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Sphingosine 1-phosphate modulates human airway smooth muscle cell functions that promote inflammation and airway remodeling in asthma

28 November 2018

1 reference

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Regulation of phosphatidylcholine homeostasis by calcium-independent phospholipase A2.

28 November 2018

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Antisense inhibition of group II phospholipase A2 expression blocks the production of prostaglandin E2 by P388D1 cells.

28 November 2018

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Generation of thromboxane A2 from highly purified human sinus mast cells after immunological stimulation

28 November 2018

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12 December 2020

Prostaglandin D2 as a mediator of allergic asthma

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12 December 2020

Effect of FTY720, a novel immunosuppressant, on adjuvant-induced arthritis in rats

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12 December 2020

Cerebrospinal fluid eicosanoid levels: endogenous PGD2 and LTC4 synthesis by antigen-presenting cells that migrate to the central nervous system

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12 December 2020

FTY720, a novel immunomodulator: efficacy and safety results from the first phase 2A study in de novo renal transplantation

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Crossref

https://api.crossref.org/works/10.1182%2FBLOOD-2006-03-011437

7 January 2021