Gene therapy in clinical medicine (Q24680275)

Postgraduate Medical Journal

Europe PubMed Central

title

Gene therapy in clinical medicine (English)

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S M Selkirk

1

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language of work or name

English

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publication date

October 2004

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published in

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volume

80

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issue

948

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page(s)

560-70

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cites work

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LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1

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On the role of RNA amplification in dsRNA-triggered gene silencing

7 April 2017

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Myocyte and myogenic stem cell transplantation in the heart

28 September 2017

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Reversal of hyperglycemia in mice by using human expandable insulin-producing cells differentiated from fetal liver progenitor cells

28 September 2017

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Progress and problems with the use of viral vectors for gene therapy

28 September 2017

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A clinical overview of cholinesterase inhibitors in Alzheimer's disease.

28 September 2017

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Bone marrow stem cells regenerate infarcted myocardium

28 September 2017

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Lentiviral-mediated RNA interference

28 September 2017

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Prospects for gene therapy using HIV-based vectors

28 September 2017

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Gene therapy of X-linked severe combined immunodeficiency

28 September 2017

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Current protocol of a research phase I clinical trial of full-length dystrophin plasmid DNA in Duchenne/Becker muscular dystrophies. Part I: rationale.

28 September 2017

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Comparison of the efficiency and safety of non-viral vector-mediated gene transfer into a wide range of human cells

28 September 2017

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Second generation adeno-associated virus type 2-based gene therapy systems with the potential for preferential integration into AAVS1.

28 September 2017

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Adenovirus as an integrating vector

28 September 2017

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Successful islet transplantation: continued insulin reserve provides long-term glycemic control

28 September 2017

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A phase I/II trial of rAd/p53 (SCH 58500) gene replacement in recurrent ovarian cancer

28 September 2017

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Simultaneous intrastriatal and intranigral fetal dopaminergic grafts in patients with Parkinson disease: a pilot study. Report of three cases

28 September 2017

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28 September 2017

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Multiple applications for replication-defective herpes simplex virus vectors

28 September 2017

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28 September 2017

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Engraftment of autologous retrovirally transduced hepatocytes after intraportal transplantation into nonhuman primates: implication for ex vivo gene therapy.

28 September 2017

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Antisense-induced exon skipping and synthesis of dystrophin in the mdx mouse

28 September 2017

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Dopamine release from nigral transplants visualized in vivo in a Parkinson's patient

28 September 2017

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ACC/AHA Guidelines for Coronary Artery Bypass Graft Surgery: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Revise the 1991 Guidelines for Coronary Artery Bypass Graft [...]

28 September 2017

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Age-associated neuronal atrophy occurs in the primate brain and is reversible by growth factor gene therapy

28 September 2017

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Lentiviral vectors--the promise of gene therapy within reach?

28 September 2017

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Angiogenesis gene therapy: phase I assessment of direct intramyocardial administration of an adenovirus vector expressing VEGF121 cDNA to individuals with clinically significant severe coronary artery disease

28 September 2017

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In situ gene therapy for adenocarcinoma of the prostate: a phase I clinical trial.

28 September 2017

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28 September 2017

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28 September 2017

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Identification of a neural stem cell in the adult mammalian central nervous system

28 September 2017

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Modification of splicing in the dystrophin gene in cultured Mdx muscle cells by antisense oligoribonucleotides

28 September 2017

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Comparison of DNA-lipid complexes and DNA alone for gene transfer to cystic fibrosis airway epithelia in vivo

28 September 2017

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Human fetal astrocytes as an ex vivo gene therapy vehicle for delivering biologically active nerve growth factor

28 September 2017

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Development of the human striatum: implications for fetal striatal transplantation in the treatment of Huntington's disease

28 September 2017

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Proliferating subventricular zone cells in the adult mammalian forebrain can differentiate into neurons and glia

28 September 2017

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Inducible gene expression systems for higher eukaryotic cells

28 September 2017

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Adenovirus-mediated in vivo gene transfer

28 September 2017

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Therapeutic angiogenesis. A single intraarterial bolus of vascular endothelial growth factor augments revascularization in a rabbit ischemic hind limb model

28 September 2017

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Selection for animal cells that express the Escherichia coli gene coding for xanthine-guanine phosphoribosyltransferase

28 September 2017

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Construction and isolation of a transmissible retrovirus containing the src gene of Harvey murine sarcoma virus and the thymidine kinase gene of herpes simplex virus type 1

28 September 2017

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Adaptation of a Retrovirus as a Eucaryotic Vector Transmitting the Herpes Simplex Virus Thymidine Kinase Gene

28 September 2017

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Factors Governing the Expression of a Bacterial Gene in Mammalian Cells

28 September 2017

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Gene therapy for human genetic disease?

28 September 2017

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Mechanism of cell transformation by RNA tumor viruses

28 September 2017

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Continuous infusion of nerve growth factor prevents basal forebrain neuronal death after fimbria fornix transection

28 September 2017

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The approaching era of the tumor suppressor genes

28 September 2017

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Tumor suppressor genes: the puzzle and the promise

28 September 2017

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Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection

28 September 2017

1 reference

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Ganciclovir. A review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy in cytomegalovirus infections

28 September 2017

1 reference

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Islet mass and function in diabetes and transplantation

28 September 2017

1 reference

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Grafts of fetal dopamine neurons survive and improve motor function in Parkinson's disease

28 September 2017

1 reference

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Genetically modified skin fibroblasts persist long after transplantation but gradually inactivate introduced genes

28 September 2017

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28 September 2017

1 reference

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Cystic fibrosis: molecular biology and therapeutic implications

28 September 2017

1 reference

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Cytotoxicity of a replication-defective mutant of herpes simplex virus type 1

28 September 2017

1 reference

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Molecular and biological properties of the vascular endothelial growth factor family of proteins

28 September 2017

1 reference

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Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donor

28 September 2017

1 reference

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The DNA Provirus Hypothesis

28 September 2017

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A phase I study of an adeno-associated virus-CFTR gene vector in adult CF patients with mild lung disease

28 September 2017

1 reference

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Nerve growth factor treatment after brain injury prevents neuronal death

28 September 2017

1 reference

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An alternative to the magic bullet paradigm for specific cancer therapy

28 September 2017

1 reference

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Nanoparticles of compacted DNA transfect postmitotic cells

28 September 2017

1 reference

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Replicative retroviral vectors for cancer gene therapy

30 May 2018

1 reference

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Maintaining cognitive function in Alzheimer disease: how effective are current treatments?

30 May 2018

1 reference

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Modulation of neuronal survival and axonal growth in vivo by tetracycline-regulated neurotrophin expression.

30 May 2018

1 reference

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Gene therapy. The best of times, the worst of times

30 May 2018

1 reference

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Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells.

30 May 2018

1 reference

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Safety of a single aerosol administration of escalating doses of the cationic lipid GL-67/DOPE/DMPE-PEG5000 formulation to the lungs of normal volunteers

30 May 2018

1 reference

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Evidence for safety and efficacy of DOTAP cationic liposome mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis

30 May 2018

1 reference

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Gene therapy in the adult primate brain: intraparenchymal grafts of cells genetically modified to produce nerve growth factor prevent cholinergic neuronal degeneration.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1743106

Increased proportion of acetylcholinesterase-rich zones and improved morphological integration in host striatum of fetal grafts derived from the lateral but not the medial ganglionic eminence.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1743106

Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain

30 May 2018

1 reference

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Somatic gene transfer of NGF to the aged brain: behavioral and morphological amelioration

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1743106

Transplanted xenogeneic neural cells in neurodegenerative disease models exhibit remarkable axonal target specificity and distinct growth patterns of glial and axonal fibres.

30 May 2018

1 reference

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Sounding boards. Gene therapy in human beings: when is it ethical to begin?

30 May 2018

1 reference

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UCLA gene therapy racked by friendly fire

30 May 2018

1 reference

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Formation of infectious progeny virus after insertion of herpes simplex thymidine kinase gene into DNA of an avian retrovirus

30 May 2018

1 reference

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Use of Viruses as Carriers of Added Genetic Information

30 May 2018

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Malignant Transformation of Cells by Viruses

30 May 2018

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Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections

30 May 2018

1 reference

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Intracerebral NGF infusion induces hyperinnervation of cerebral blood vessels

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1743106

Transfer and expression of the lacZ gene in rat brain neurons mediated by herpes simplex virus mutants

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1743106

In vivo release of dopa and dopamine from genetically engineered cells grafted to the denervated rat striatum

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1743106

30 May 2018

Cancer statistics, 1990.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1743106

Hypophagia is induced by intracerebroventricular administration of nerve growth factor

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1743106

Morphological and neurochemical features of cultured primary skin fibroblasts of Fischer 344 rats following striatal implantation

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1743106

Lentiviral vector-mediated delivery of short hairpin RNA results in persistent knockdown of gene expression in mouse brain

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1743106

Minimal toxicity of stabilized compacted DNA nanoparticles in the murine lung

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1743106

Local gene knockdown in the brain using viral-mediated RNA interference.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1743106

Phase I trial of intranasal and endobronchial administration of a recombinant adeno-associated virus serotype 2 (rAAV2)-CFTR vector in adult cystic fibrosis patients: a two-part clinical study

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1743106

Phase I trial of adenovirus-mediated p53 gene therapy for recurrent glioma: biological and clinical results

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1743106

Simian immunodeficiency virus-based lentivirus vector for retinal gene transfer: a preclinical safety study in adult rats

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1743106

Therapeutic antisense-induced exon skipping in cultured muscle cells from six different DMD patients.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1743106

Induction of p53-regulated genes and tumor regression in lung cancer patients after intratumoral delivery of adenoviral p53 (INGN 201) and radiation therapy.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1743106

A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1743106

Phase I study of direct administration of a replication deficient adenovirus vector containing the vascular endothelial growth factor cDNA (CI-1023) to patients with claudication

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1743106

Current protocol of a research phase I clinical trial of full-length dystrophin plasmid DNA in Duchenne/Becker muscular dystrophies. Part II: clinical protocol

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1743106

A phase II, double-blind, randomized, placebo-controlled clinical trial of tgAAVCF using maxillary sinus delivery in patients with cystic fibrosis with antrostomies.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1743106

Herpes simplex-mediated gene transfer of nerve growth factor protects against peripheral neuropathy in streptozotocin-induced diabetes in the mouse

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1743106

Syngeneic central nervous system transplantation of genetically transduced mature, adult astrocytes

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1743106

Donepezil in the treatment of Alzheimer's disease: long-term efficacy and safety

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1743106

In vivo gene therapy for pyridoxine-induced neuropathy by herpes simplex virus-mediated gene transfer of neurotrophin-3.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1743106

RNAi as random degradative PCR: siRNA primers convert mRNA into dsRNAs that are degraded to generate new siRNAs.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1743106

A phase I study of aerosolized administration of tgAAVCF to cystic fibrosis subjects with mild lung disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1743106

HSV-tk gene therapy for human renal cell carcinoma in nude mice

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1743106

RNA interference. The short answer.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1743106

Gene therapy. FDA moves against Penn scientist

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1743106

Phase I study of adenoviral delivery of the HSV-tk gene and ganciclovir administration in patients with current malignant brain tumors.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1743106

Gene therapy death prompts review of adenovirus vector

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1743106

Adenovirus-mediated acidic fibroblast growth factor gene transfer induces angiogenesis in the nonischemic rabbit heart

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1743106

A phase 1-2 clinical trial of gene therapy for recurrent glioblastoma multiforme by tumor transduction with the herpes simplex thymidine kinase gene followed by ganciclovir. GLI328 European-Canadian Study Group

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1743106

Targeting of marrow-derived astrocytes to the ischemic brain.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1743106

Impact of preexisting and induced humoral and cellular immune responses in an adenovirus-based gene therapy phase I clinical trial for localized mesothelioma.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1743106

Intracerebroventricular infusion of nerve growth factor in three patients with Alzheimer's disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1743106

Exon–Intron Organization of the Human Dystrophin Gene

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1743106

Oncogenes and tumor suppressor genes.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1743106

Insertion of a New Gene of Viral Origin into Bone Marrow Cells of Mice

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1743106

Prospects for Human Gene Therapy

28 November 2018

1 reference

12 December 2020

Angiogenic-induced enhancement of collateral blood flow to ischemic myocardium by vascular endothelial growth factor in dogs

1 reference

12 December 2020

Administration of an adenovirus containing the human CFTR cDNA to the respiratory tract of individuals with cystic fibrosis

1 reference

12 December 2020

Acyclic guanosine analogs inhibit DNA polymerases alpha, delta, and epsilon with very different potencies and have unique mechanisms of action

1 reference

12 December 2020

Adenovirus gene transfer causes inflammation in the brain

1 reference

12 December 2020

Delayed recovery of movement-related cortical function in Parkinson's disease after striatal dopaminergic grafts

1 reference

12 December 2020

Myocardial infarction and cardiac remodelling in mice

1 reference

12 December 2020

Regional Angiogenesis with Vascular Endothelial Growth Factor (VEGF) in peripheral arterial disease: Design of the RAVE trial

1 reference

12 December 2020

Transplanted human cord blood cells give rise to hepatocytes in engrafted mice

1 reference

12 December 2020

Biologic bypass with the use of adenovirus-mediated gene transfer of the complementary deoxyribonucleic acid for vascular endothelial growth factor 121 improves myocardial perfusion and function in the ischemic porcine heart

1 reference

12 December 2020

A double-blind, placebo controlled, dose ranging study to evaluate the safety and biological efficacy of the lipid-DNA complex GR213487B in the nasal epithelium of adult patients with cystic fibrosis

1 reference

12 December 2020

Efficient and persistent gene transfer of AAV-CFTR in maxillary sinus

1 reference

12 December 2020

Selective growth stimulating effects of mouse sarcoma on the sensory and sympathetic nervous system of the chick embryo

1 reference

12 December 2020

Reconstruction of the nigrostriatal dopamine pathway by intracerebral nigral transplants

1 reference

12 December 2020

Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy

1 reference

12 December 2020

Duchenne muscular dystrophy: deficiency of dystrophin-associated proteins in the sarcolemma

1 reference

12 December 2020