Misfolding diverts CFTR from recycling to degradation: quality control at early endosomes (Q24676764)

11

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Blake Papsin

8

object named as

Blake Papsin

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author name string

Manu Sharma

1

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Francesca Pampinella

2

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Csilla Nemes

3

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Mohamed Benharouga

4

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Jeffrey So

5

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Kai Du

6

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Kristi G Bache

7

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Noa Zerangue

STAM proteins bind ubiquitinated proteins on the early endosome via the VHS domain and ubiquitin-interacting motif

9

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language of work or name

English

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publication date

15 March 2004

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published in

Journal of Cell Biology

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volume

164

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page(s)

923-33

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issue

6

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cites work

1 reference

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Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein-ubiquitin conjugates

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Mechanisms underlying ubiquitination

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The Vps27p Hse1p complex binds ubiquitin and mediates endosomal protein sorting.

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A transmembrane ubiquitin ligase required to sort membrane proteins into multivesicular bodies

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Receptor downregulation and multivesicular-body sorting

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Non-traditional functions of ubiquitin and ubiquitin-binding proteins

7 April 2017

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Themes and variations on ubiquitylation

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Signals for sorting of transmembrane proteins to endosomes and lysosomes

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Regulation of Membrane Protein Transport by Ubiquitin and Ubiquitin-Binding Proteins

7 April 2017

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Quality control in the endoplasmic reticulum

7 April 2017

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Hrs sorts ubiquitinated proteins into clathrin-coated microdomains of early endosomes

7 April 2017

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Setting the standards: quality control in the secretory pathway

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Endocytosis and molecular sorting

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Vps27-Hse1 and ESCRT-I complexes cooperate to increase efficiency of sorting ubiquitinated proteins at the endosome.

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Recognition of a single transmembrane degron by sequential quality control checkpoints

28 September 2017

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ER-associated degradation in protein quality control and cellular regulation

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Secretory pathway quality control operating in Golgi, plasmalemmal, and endosomal systems

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Epsins and Vps27p/Hrs contain ubiquitin-binding domains that function in receptor endocytosis

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Bilayered clathrin coats on endosomal vacuoles are involved in protein sorting toward lysosomes

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A mutant plasma membrane ATPase, Pma1-10, is defective in stability at the yeast cell surface

28 September 2017

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COOH-terminal truncations promote proteasome-dependent degradation of mature cystic fibrosis transmembrane conductance regulator from post-Golgi compartments

28 September 2017

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The role of a conserved inter-transmembrane domain interface in regulating alpha(2a)-adrenergic receptor conformational stability and cell-surface turnover

28 September 2017

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Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases

28 September 2017

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Conformational and temperature-sensitive stability defects of the delta F508 cystic fibrosis transmembrane conductance regulator in post-endoplasmic reticulum compartments.

28 September 2017

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Degradation signals recognized by the Ubc6p-Ubc7p ubiquitin-conjugating enzyme pair

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The recycling endosome of Madin-Darby canine kidney cells is a mildly acidic compartment rich in raft components

28 September 2017

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Down-regulation of cell surface receptors is modulated by polar residues within the transmembrane domain

28 September 2017

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Ubiquitination and endocytosis of plasma membrane proteins: role of Nedd4/Rsp5p family of ubiquitin-protein ligases

28 September 2017

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Monoubiquitin carries a novel internalization signal that is appended to activated receptors

28 September 2017

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ER protein quality control and proteasome-mediated protein degradation

28 September 2017

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C-terminal truncations destabilize the cystic fibrosis transmembrane conductance regulator without impairing its biogenesis. A novel class of mutation

28 September 2017

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Substrate targeting in the ubiquitin system

28 September 2017

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DeltaF508 CFTR protein expression in tissues from patients with cystic fibrosis

28 September 2017

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Yeast mutants affecting possible quality control of plasma membrane proteins

28 September 2017

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Degradation signals for ubiquitin system proteolysis in Saccharomyces cerevisiae

28 September 2017

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Aggregation as a determinant of protein fate in post-Golgi compartments: role of the luminal domain of furin in lysosomal targeting

28 September 2017

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Cystic fibrosis: genotypic and phenotypic variations

28 September 2017

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Evidence for nonvectorial, retrograde transferrin trafficking in the early endosomes of HEp2 cells.

28 September 2017

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28 September 2017

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Degradation signal masking by heterodimerization of MATalpha2 and MATa1 blocks their mutual destruction by the ubiquitin-proteasome pathway.

28 September 2017

1 reference

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A Chinese hamster cell cycle mutant arrested at G2 phase has a temperature-sensitive ubiquitin-activating enzyme, E1.

30 May 2018

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Empty MHC class I molecules come out in the cold

30 May 2018

1 reference

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Processing of mutant cystic fibrosis transmembrane conductance regulator is temperature-sensitive

30 May 2018

1 reference

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Protein quality control: U-box-containing E3 ubiquitin ligases join the fold

30 May 2018

1 reference

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Conformational Stability Is a Determinant of Ribonuclease A Cytotoxicity

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172283

Biosynthesis and degradation of CFTR.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172283

Protein folding stability can determine the efficiency of escape from endoplasmic reticulum quality control.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2172283

28 November 2018

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Glycerol reverses the misfolding phenotype of the most common cystic fibrosis mutation.

28 November 2018

1 reference

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Limited proteolysis as a probe for arrested conformational maturation of delta F508 CFTR

28 November 2018

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12 December 2020

Is protein turnover thermodynamically controlled?

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12 December 2020

The structural stability of a protein is an important determinant of its proteolytic susceptibility in Escherichia coli

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12 December 2020

The Delta F508 mutation shortens the biochemical half-life of plasma membrane CFTR in polarized epithelial cells

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12 December 2020

Identifiers

DOI

10.1083/JCB.200312018

1 reference

1721455

1721455

1 reference

1 reference

1 reference