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Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor (Q24676286)

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English	Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor	scientific article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7853496%20AND%20SRC:MED&resulttype=core&format=json

27 October 2019

Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor (English)

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Europe PubMed Central

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27 October 2019

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C H Herrmann

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27 October 2019

A P Rice

2

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27 October 2019

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1 March 1995

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27 October 2019

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Journal of Virology

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27 October 2019

69

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27 October 2019

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27 October 2019

1612-1620

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PMC publication ID

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27 October 2019

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

7 April 2017

In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

7 April 2017

A cDNA for a protein that interacts with the human immunodeficiency virus Tat transactivator

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

7 April 2017

Sp1-dependent activation of a synthetic promoter by human immunodeficiency virus type 1 Tat protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

7 April 2017

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

7 April 2017

Direct interaction of human TFIID with the HIV-1 transactivator tat

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

7 April 2017

Activation of transcription by HIV-1 Tat protein tethered to nascent RNA through another protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

7 April 2017

HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

7 April 2017

Phosphorylation of RNA polymerase II C-terminal domain and transcriptional elongation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

7 April 2017

Control of RNA initiation and elongation at the HIV-1 promoter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

7 April 2017

Anti-termination of transcription within the long terminal repeat of HIV-1 by tat gene product

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

7 April 2017

HIV-1 Tat protein increases transcriptional initiation and stabilizes elongation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

7 April 2017

RNA polymerase II transcription cycles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

28 September 2017

The human immunodeficiency virus type 1 long terminal repeat specifies two different transcription complexes, only one of which is regulated by Tat

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

28 September 2017

TAR RNA binding properties and relative transactivation activities of human immunodeficiency virus type 1 and 2 Tat proteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

28 September 2017

Genetic analysis of the cofactor requirement for human immunodeficiency virus type 1 Tat function.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

28 September 2017

Tat and the HIV-1 promoter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

28 September 2017

Functional analysis of interactions between Tat and the trans-activation response element of human immunodeficiency virus type 1 in cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

28 September 2017

Human immunodeficiency virus type 1 transactivator protein, tat, stimulates transcriptional read-through of distal terminator sequences in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

28 September 2017

RNA polymerase II is aberrantly phosphorylated and localized to viral replication compartments following herpes simplex virus infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

28 September 2017

Exon2 of HIV-2 Tat contributes to transactivation of the HIV-2 LTR by increasing binding affinity to HIV-2 TAR RNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

28 September 2017

Tyrosine phosphorylation of mammalian RNA polymerase II carboxyl-terminal domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

28 September 2017

Mechanism of action of dichloro-beta-D-ribofuranosylbenzimidazole: effect on in vitro transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

28 September 2017

Genetic analysis of the repetitive carboxyl-terminal domain of the largest subunit of mouse RNA polymerase II

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

28 September 2017

The C-terminal domain of the largest subunit of RNA polymerase II of Saccharomyces cerevisiae, Drosophila melanogaster, and mammals: a conserved structure with an essential function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

28 September 2017

A unique structure at the carboxyl terminus of the largest subunit of eukaryotic RNA polymerase II.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

28 September 2017

Location of the trans-activating region on the genome of human T-cell lymphotropic virus type III.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

28 September 2017

Equine infectious anemia virus: immunopathogenesis and persistence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

28 September 2017

Structural analysis of wild-type and mutant human immunodeficiency virus type 1 Tat proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

28 September 2017

HIV-1 Tat protein trans-activates transcription in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

28 September 2017

Transcription elongation and eukaryotic gene regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

28 September 2017

Efficient trans-activation by the HIV-2 Tat protein requires a duplicated TAR RNA structure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

28 September 2017

Mutational analysis of the conserved cysteine-rich region of the human immunodeficiency virus type 1 Tat protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

28 September 2017

Trans-activation by HIV-1 Tat via a heterologous RNA binding protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

28 September 2017

The role of Tat in the human immunodeficiency virus life cycle indicates a primary effect on transcriptional elongation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

28 September 2017

Isolation of a cellular protein that binds to the human immunodeficiency virus Tat protein and can potentiate transactivation of the viral promoter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

28 September 2017

The biochemistry of AIDS.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

28 September 2017

HIV-1 Tat protein promotes formation of more-processive elongation complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

28 September 2017

Tat transactivation of the human immunodeficiency virus type 1 promoter is influenced by basal promoter activity and the simian virus 40 origin of DNA replication.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

28 September 2017

A minimal lentivirus Tat

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

28 September 2017

Mutational analysis of the equine infectious anemia virus Tat-responsive element

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

28 September 2017

Identification of lentivirus tat functional domains through generation of equine infectious anemia virus/human immunodeficiency virus type 1 tat gene chimeras

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

28 September 2017

Control of formation of two distinct classes of RNA polymerase II elongation complexes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

28 September 2017

Stability of Drosophila RNA polymerase II elongation complexes in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

28 September 2017

Inhibition of human immunodeficiency virus type 1 Tat activity by coexpression of heterologous trans activators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

28 September 2017

Mutational analysis of the amino and carboxy termini of the HIV-2 Tat protein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

30 May 2018

A quantitative assay for trans-activation by HIV-1 Tat, using liposome-mediated DNA uptake and a parallel ELISA system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

30 May 2018

Specific interaction of the human immunodeficiency virus Tat proteins with a cellular protein kinase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

30 May 2018

Trans-activation of human immunodeficiency virus occurs via a bimodal mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

30 May 2018

Casein kinase type II is involved in the inhibition by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole of specific RNA polymerase II transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

30 May 2018

Functional redundancy and structural polymorphism in the large subunit of RNA polymerase II.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

30 May 2018

5,6-Dichloro-1-beta-D-ribofuranosylbenzimidazole inhibits transcription elongation by RNA polymerase II in vitro.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

30 May 2018

Synergy between HIV-1 Tat and adenovirus E1A is principally due to stabilization of transcriptional elongation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

30 May 2018

Blocking of Tat-dependent HIV-1 RNA modification by an inhibitor of RNA polymerase II processivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

30 May 2018

Purification of protein kinases that phosphorylate the repetitive carboxyl-terminal domain of eukaryotic RNA polymerase II.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

30 May 2018

Analysis of arginine-rich peptides from the HIV Tat protein reveals unusual features of RNA-protein recognition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

30 May 2018

Identification of phosphorylation sites in the repetitive carboxyl-terminal domain of the mouse RNA polymerase II largest subunit.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

30 May 2018

Promoter-dependent phosphorylation of RNA polymerase II by a template-bound kinase. Association with transcriptional initiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

30 May 2018

Trans-dominant Tat mutants with alterations in the basic domain inhibit HIV-1 gene expression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

30 May 2018

High affinity binding of TAR RNA by the human immunodeficiency virus type-1 tat protein requires base-pairs in the RNA stem and amino acid residues flanking the basic region

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

28 November 2018

Partial purification and characterization of two distinct protein kinases that differentially phosphorylate the carboxyl-terminal domain of RNA polymerase subunit IIa.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

28 November 2018

Transcriptional elongation by RNA polymerase II is stimulated by transactivators.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=188757

28 November 2018

Wild-type and mutant HIV-1 and HIV-2 Tat proteins expressed in Escherichia coli as fusions with glutathione S-transferase

1 reference

https://pubmed.ncbi.nlm.nih.gov/7853496

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

5,6-Dichloro-1-Beta-D-ribofuranosylbenzimidazole inhibits initiation of nuclear heterogeneous RNA chains in HeLa cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/7853496

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DRB-induced premature termination of late adenovirus transcription

1 reference

https://pubmed.ncbi.nlm.nih.gov/7853496

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A bulge structure in HIV-1 TAR RNA is required for Tat binding and Tat-mediated trans-activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/7853496

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Messenger RNA synthesis in mammalian cells is catalyzed by the phosphorylated form of RNA polymerase II

1 reference

https://pubmed.ncbi.nlm.nih.gov/7853496

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

5,6-Dichloro-1-beta-D-ribofuranosylbenzimidazole inhibits a HeLa protein kinase that phosphorylates an RNA polymerase II-derived peptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/7853496

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The HIV-1 Tat protein activates transcription from an upstream DNA-binding site: implications for Tat function

1 reference

https://pubmed.ncbi.nlm.nih.gov/7853496

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA binding provides a signal for phosphorylation of the RNA polymerase II heptapeptide repeats

1 reference

https://pubmed.ncbi.nlm.nih.gov/7853496

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Specific interaction between the nonphosphorylated form of RNA polymerase II and the TATA-binding protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/7853496

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human general transcription factor IIH phosphorylates the C-terminal domain of RNA polymerase II

1 reference

https://pubmed.ncbi.nlm.nih.gov/7853496

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Positive patches and negative noodles: linking RNA processing to transcription?

1 reference

https://pubmed.ncbi.nlm.nih.gov/7853496

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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